Yazar "Cengiz M." seçeneğine göre listele

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    Cetuximab plus radiotherapy for head and neck cancer [10]
    (2006) Cengiz M.; Yildiz F.; Genc M.
    [Abstract not Available]
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    Doxorubicin induced nephrotoxicity: Protective effect of nicotinamide
    (2011) Oktem G.; Ayla S.; Seckin I.; Tanriverdi G.; Cengiz M.; Eser M.; Soner B.C.
    Introduction. Nephrotoxicity is one of the important side effects of anthracycline antibiotics. The aim of this study was to investigate the effects of nicotinamide (NAD), an antioxidant agent, against nephrotoxicity induced by doxorubicin (DXR). Methods. The rats were divided into control, NAD alone, doxorubicin (20mg/kg, i.p.) and DXR plus NAD (200mg/kg, i.p.) groups. At the end of the 10th day, kidney tissues were removed for light microscopy and analysis. The level of tissues' catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), inducible nitric oxide (iNOS) and endothelial nitric oxide (eNOS) activities were determined. Results. The activities of CAT, GPx, and GSH were decreased, and Po was increased in renal tissue of doxorubicin group compared with other groups. The tissue of the doxorubicin group showed some histopathological changes such as glomerular vacuolization and degeneration, adhesion to Bowman's capsule and thickening and untidiness of tubular and glomerular capillary basement membranes. Histopathological examination showed that NAD prevented partly DXR-induced tubular and glomerular damage. Conclusions. Pretreatment with NAD protected renal tissues against DXR-induced nephrotoxicity. Preventive effects of NAD on these renal lesions may be via its antioxidant and anti-inflammatory action. Copyright © 2011 Sule Ayla et al.
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    Synthesis of norbornadiene-containing polyamide based polymer
    (Chemical Publishing Co., 2016) Mutlu M.; Cengiz M.; Gülce A.
    Synthesis of polyamide-based polymer containing norbornadiene was aimed in this study. Aromatic group containing cyclopentadiene was synthesized primarily. Cyclopentadiene was converted to cyclopentadienyl anion through the reaction with metallic sodium. Substituent containing aryl group was linked to the 5-position of cyclopentadiene by reacting the resulting anion with halide compound. Diethyl 7-arylmethyl-2,5-norbornadiene-2,3-dicarboxylate monomer was synthesized by [4 + 2] (Diels Alder) cycloaddition reaction of substitute obtained this way with cyclopentadiene diethyl 2-butyndioate. By activating this synthesized monomer with diaminoethane, targeted polyamide-based polymer containing norbornadiene was reached. Changes in functional group in the polymerization reaction were monitored by FTIR spectroscopy technique. Moreover, in order to clarify the structure of the polymer obtained, IR and 1H NMR spectra were recorded. © 2016, Chemical Publishing Co. All rights reserved.