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Öğe Acute Arterial Embolus(WESTMINSTER PUBL INC, 1991) Solak, Hasan; Yeniterzi, Mehmet; Yüksek, Tahir; Özpınar, Cevat; Ceran, SamiBetween December, 1983, and December, 1988, 100 patients (54 men, 46 women) with acute arterial embolus, ranging in age from twenty-three to eighty-three years, were treated in our clinics. The main symptom of the patients was pain (94%), followed by coldness (72%), pallor (64%), sensory defect (42%), motor disorder (37%), muscular rigidity (10%), and tissue necrosis (7%). We have determined the etiology to be atrial fibrillation in 53 cases, 36 of which arose from mitral stenosis: acute myocardial infarction (MI) in 14 cases; thromboembolus based on arteriosclerosis obliterans (ASO) in 27 cases; and tumor embolus in 2 cases; 4 cases could not be explained etiologically. The most common site of embolism was the femoral artery (33%). Arterial exploration was done under local anesthesia in the 76 patients who did not have distal localization of the embolus. Embolectomy was performed in 49 of these cases and embolectomy plus localized tromboendarterectomy in 27. Owing to developing necrosis, amputation was necessary in 6 cases-4 above the knee and 2 above the elbow. Motor and sensory defect persisted to various degrees in 27 cases. The death rate was 4%.Öğe Analysis of chromosomes 9 and 11 aneuploidy frequency in pleural effusion of patients with and without malignancy - Interphase FISH technique(TAYLOR & FRANCIS INC, 2005) Çora, Tülin; Acar, Hasan; Ceran, Sami; Bodur, SaidFluids of body cavities result in a series of pathophysiological events associated with non-malignant and malignant conditions that lead to the formation of exudative effusion. Diagnosis of effusion from the patients is frequently troublesome for the cytologist because of the differentiation and biological behavior of different cells type in effusion. In the present study, chromosomal aneuploidy status in effusion cells derived from 32 patients including 14 patients with non-malignant diseases and 18 patients with malignant diseases [including malign mesothelioma (n = 6), adeno carcinoma (n = 10), small cell carcinoma (n = 2)] was analyzed by using fluorescence in situ hybridization (FISH) with centromere specific probes for chromosomes 9 and 11. There was significant difference in the incidence of chromosomal 9 and 11 aneuploidies when compared with controls (P = 0.000). However, aneuploidies of chromosomes 9 and 11 in effusion cells from patients with malignant disease had significantly higher than in effusion cells from patients with non-malignant (P = 0.000), suggesting that chromosomes 9 and 11 are frequently involved in the status of disease. The present study indicates that there is a association between chromosomes aneuploidies and pleural effusion cell status. Chromosome aneuploidies in non-malignant group may be an indicator of premalignancy.Öğe Bilateral Aneurysms of the Pulmonary Artery with Pectus Excavatum - A Case Report(WESTMINSTER PUBL INC, 1993) Özpınar, Cevat; Ceran, Sami; Yeniterzi, Mehmet; Yüksek, Tahir; Özergin, Ufuk; Solak, HasanAn eleven-year-old boy was operated on for a left-sided pulmonary artery aneurysm. The same patient had also been operated three years earlier because of a right sided aneurysm.Öğe Bronchocele: Demonstration By 3D Volume Rendering Imaging with Multidetector Computed Tomography: Case Report(ORTADOGU AD PRES & PUBL CO, 2011) Sakarya, Mehmet Emin; Ceran, Sami; Koc, Osman; Ozbek, Orhan; Karabekmez, Leman G.; Odev, KemalCongenital bronchial atresia (CBA) is a rare congenital abnormality of the lung. It results from a congenital focal obliteration of a proximal segmental or sub-segmental bronchus with normal development of distal structures. Because of proksimal bronchial stenosis, the distal bronchi became filled with mucus and form a bronchocele. Three dimensional (3D) volume rendering (VR) imaging was performed with 64-slice multidetector computed tomography (MDCT) equipment in a patient with CBA and bronchocele. 3D VR images clearly revealed branching nonenhancing tubular structure and the adjacent lung with features of air trapping. A diagnosis of bronchocele was made radiologically. We report a case of bronchocele documented by 3D image reconstruction and VR images using 64-slice MDCT. In this article we report that, the radiologic findings of the broncocele can be shown more clearly with 3D VR technique than standan CT imaging.Öğe Chest Trauma in Children(2002) Ceran, Sami; Sunam, Güven Sadi; Arıbaş, Olgun Kadir; Görmüş, Niyazi; Solak, HasanObjectives: Chest trauma in childhood is uncommon in clinical practice. The management and treatment principles of children with thoracic trauma were discussed with the data reported in the literature. Methods: Of the chest injury diagnosed in 1653 patients, 225 were children in the last 17-year period. There were 199 boys (88.44%) and 26 girls (11.55%). The most common causes were blunt injuries in 135 cases (60%), stab wounds in 67 cases (29.77%) and gunshot wounds in 22 cases (9.77%). Results: Out of 225, 217 patients were treated conservatively and eight patients were treated surgically. There was no mortality and morbidity. Conclusions: The prevalence of chest trauma in children due to blunt injuries is high in Turkey. Extremity injury is thought to be the most commonly associated extra-thoracic injury. However, thoracic trauma in children can be managed conservatively in most of the cases.Öğe A comparison of the efficacies of heterologous blood, rifamycin, and talc as pleural sclerosants in rabbits: An experimental study(2012) Döngel, İsa; Sunam, Güven Sadi; Külahcı, Özgür; Ceran, SamiAmaç: Bu çalışmada tavşanlarda rifamisin plörodezis etkinliği araştırıldı. Çalışma planı: Çalışmada ortalama ağırlıkları 3433 g olan toplam 21 adet erkek Yeni Zelanda türü albino tavşan kullanıldı. Bir adet tavşan kan temininde kullanıldı. Diğer 20 tavşan kontrol grubu, heterolog kan grubu, rifamisin grubu ve talk grubu olarak dört gruba ayrıldı. Tavşanlara gruplarına göre sol hemitoraksa takılan kateterden distile su, heterolog taze kan, rifamisin ve steril sıvı talk verildi. Yirmi sekizinci günde tavşanlar yüksek doz anestezi ile sakrifiye edildi. Plevrada makroskopik olarak plörodezis varlığı ve mikroskopik olarak plevral kalınlıkları ölçüldü ve inflamasyon ve fibrozis bulguları araştırıldı. Plörodezis derecesi 0’dan 4’e kadar olan skalada değerlendirildi. Bulgular: Makroskopik ve mikroskopik seviyede kontrol grubu ile heterolog kan grubu arasında istatistiksel olarak a nlamlı fark bulunmadı (p0.05). Talk ve rifamisin grubunda plörodezis derecesi kontrol ve heterolog kan grubundan daha yüksek idi (p0.04). Rifamisin grubu ile talk grubu arasında makroskopik ve mikroskopik incelemede anlamlı fark bulunmadı (p0.05). Plevral fibrozis kalınlığının medyan değerleri kontrol, heterolog kan, rifamisin ve talk grupları için sırasıyla 10 (10-29), 26 (10-71), 312 (264-351) ve 304 (238-331) ?m ölçüldü. Sonuç: Tavşanlarda rifamisin plörodezis etkinliği mikroskopik ve makroskopik olarak talk grubu ile benzer; kontrol ve heterolog kan grubuna göre daha üstün bulundu.Öğe Congenital lobar emphysema: Is surgery routinely necessary(2010) Ceran, Sami; Altuntaş, Bayram; Sunam, Güven Sami; Bulut, İsmetCongenital lobar emphysema (CLE) is a rare congenital abnormality characterised by overinflation of a pulmonary lobe. Its aetiology is unknown. The management of CLE has traditionally been surgical. A newborn boy with a birthweight of 2.5 kg was delivered at full-term by caesarian section due to food delivery. There was no marked respiratory distress at birth, and little meconium stained liquor was seen on the skin. The initial diagnosis was meconium aspiration syndrome. After computed tomography of the thorax, CLE was diagnosed. The patient was observed throughout for a week and the CT of the thorax was repeated, which revealed that the emphysema had resolved. The nonoperative approach should be considered in asymptomatic patients with CLE.Öğe Cost-Effective and Time-Saving Surgical Treatment of Pulmonary Hydatid Cysts With Multiple Localization(Springer-Verlag, 2002) Ceran, Sami; Sunam, Güven Sadi; Görmüş, Niyazi; Solak, Hasan; Şahin, MustafaPurpose. The most frequent anatomic locations of hydatid cysts are the liver and lungs. Because there is no effective medical therapy against this parasitic disease, surgery is the treatment of choice. The aim of this retrospective study was to compare the cost and effect of a one-stage operation with those of two- or three-stage operations in the treatment of lung hydatid cysts with multiple localizations. Methods. We evaluated 364 patients who underwent surgical treatment for hydatid cysts, all of whom had multiple localizations. To avoid two- or three-staged operations, we performed median sternotomy, simultaneous bilateral thoracotomy and unilateral thoracotomy with a transdiaphragmatic approach. Results. For the treatment of 460 hydatid cyst localizations in 364 patients, a collective 381 operations were performed. The number of operations and periods of hospitalization were reduced. Conclusion. A one-stage surgical procedure for bilateral lung and liver hydatid cysts is superior to the traditional two- and three-stage operations because it reduces morbidity, hospital stay, and cost.Öğe CT Diagnosis of Granulomatous Mediastinitis due to Tuberculosis(ELSEVIER SCI IRELAND LTD, 1996) Ödev, Kemal; Özer, Faruk; Ceran, Sami; Karabacakoğlu, Aydın; Vural, AlaaddinTuberculosis is an important cause of mediastinal granuloma with fibrosing mediastinitis [1,2]. Fibrosing mediastinitis is a chronic process and a late manifestation of mediastinal granuloma. Chronic granulomatous inflammation is characterized by slow progression of fibrosis and fibrocaseous granulomas which develop in the regional mediastinal lymph nodes [2,3]. Plain chest radiograph often confirms the presence of a widened mediastinum but rarely helps in defining the etiology. Cross-sectional imaging of the mediastinum by computed tomography (CT) has become the method of choice for further investigation of a mediastinal abnormality [4]. Magnetic resonance imaging (MRI), on the other hand, can show the vasocompressive effects of fibrosis without the need for intravenous contrast opacification [5]. We report two cases of chronic fibrosing mediastinitis, which is one of the late manifestations of tuberculous infection.Öğe The effects of preoperative chemotherapy and beta glucan on bronchial anastomosis in rabbits: a preliminary study(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2015) Altuntaş, Bayram; Ceran, Sami; Sunam, Güven; Gültekin, Mustafa; Esen, HasanBackground: This study aims to investigate the effects of an immunostimulant, beta glucan, on the bronchial anastomosis in rabbits that received chemotherapy in preoperative period. Methods: Forty-five New Zealand male rabbits were used in this study. The rabbits were divided into three groups as group 1 (control), group 2 (chemotherapy), and group 3 (chemotherapy + beta glucan) with 15 rabbits in each group. The left main bronchus was incised completely and then end-to-end anastomosis was performed in all groups. Cisplatin was administered on the preoperative first day and etoposide was administered on the preoperative first, second, and third days in group 2. In group 3, in addition to the same chemotherapy protocol, 10 mg/kg/day beta glucan was administered via enteral route starting from seven days before operation until one day before sacrifications. The rabbits were sacrificed at postoperative third, fifth, and seventh days by groups of five. The bronchial anastomosis lines were removed and tissue sections were stained with hematoxylin and eosin. Results: In pathological analysis, while there were statistically significant differences between group 1 and group 2 and between group 2 and group 3, there was no difference between group 1 and group 3 in terms of bronchial healing. Conclusion: The use of beta glucan during chemotherapy treatment may improve bronchial healing at postoperative period.Öğe Effects of selective NOS inhibition in sepsis: Evaluation of lung tissue damage and blood gases(INT COLLEGE OF SURGEONS, 2008) Ceran, Sami; Erikoğlu, Mehmet; Şahin, Mustafa; Sunarn, Güven Sadi; Gölcük, Murat; Paşaoğlu, Hatice; Avşar, FatihNO is an important mediator in the generalized inflammatory response of the body during sepsis and septic shock. We investigated the possible effects Of L-arginine and aminoguanidine on plasma NO levels and the interaction between NO levels and lung tissue damage and blood gases in sepsis. Fifty Wistar male rats were used in this study and divided into five groups: group 1, sham group; group 2, CLP (sepsis); group 3, CLP + 10 mg/kg L-arginine administration; group 4, CLP +15 mg/kg aminoguanidine administration; group 5: CLP + L-arginine + aminoguanidine given in similar doses. Sepsis was induced by cecal ligation and puncture (CLP) method. Drugs were administered at postoperative hours 4 and 12. The levels in the aminoguanidine and aminoguanidine + L-arginine groups were similar to the sham group. Lung tissue damage in the sepsis and L-arginine groups was more severe than the other groups.Öğe Giant Benign Mediastinal Masses Extending into the Pleural Cavity(THIEME MEDICAL PUBL INC, 2016) Sunam, Guven Sadi; Oncel, Murat; Ceran, Sami; Odev, Kemal; Yildiran, HuseyinIntroduction The aim of the study was to evaluate the results of surgery to remove huge mediastinal masses and their pathology. Surgical resection was chosen for accurate diagnosis and treatment of the huge mediastinal masses extending into the pleural cavity. Methods Records were reviewed for eight patients who had the diagnosis of huge benign mediastinal masses and who underwent operation; details of the patients and operations were recorded. Results Mean age was 34.5 (range 22 to 44) years, and male-to-female ratio was 2:6. Computed tomography and magnetic resonance imaging (MRI) were used to evaluate the location and extent of the abnormality and to characterize the tissue components of the mass. Most of the tumors were located in the posterior mediastinum. The most frequent presenting symptom was exertional dyspnea. The majority of cases underwent posterolateral thoracotomy, and complete resection was possible in seven patients. Partial resection could only be performed in one. The mean diameter of the resected masses was 15 x 10 cm. Histopathologic examination revealed 3 neurogenic tumors, 2 teratomas, 1 thymolipoma, and 1 ectopic thyroid, and 1 hemangioma. Minor complication was seen in two cases. Conclusion The presurgical thoracic MRI provided correct diagnosis along with radiologic characterization and topography. Surgery must be the preferred treatment in huge benign mediastinal masses.Öğe Intrathoracic Extrapulmonary Hydatid Disease: Radiologic Manifestations(Elsevier Science Bv, 2010) Emlik, Dilek; Kireşi, Demet; Sunam, Güven Sadi; Kıvrak, Ali Sami; Ceran, Sami; Ödev, KemalHydatidosis is a parasitic disease caused by the larvae of Echinococcus granulosus and rarely by Echinococcus alveolaris. It is endemic to South America, North Africa, Asia, Australia, and the Middle East [1,2]. The definitive hosts are foxes and, less commonly, dogs and cats. Humans are infected by direct contact with an infected animal or by ingestion of contaminated food or fluids. Echinococcal embryos migrate through the intestinal mucosa, and, in 60%e70% of cases, reach the liver via the portal system [1]. They can then enter the systemic circulation via the porta caval anastomoses and be carried by the bloodstream to any organ or tissue in the body. Alternatively, the eggs can be inhaled and cause primary lung disease [2]. Intrathoracic extrapulmonary hydatid disease is very rare but can occur in the pleural space, extrapleural region, pleural fissure, chest wall, mediastinum, pericardium, myocardium, and diaphragm [1]. In this pictorial essay, we present the clinical manifestations and imaging features of patients with hydatid cysts (HC) in the extrapulmonary sites of the thorax.Öğe Köpek ısırığına bağlı pnömotoraks olgusu(2002) Sunam, Güven Sadi; Ceran, Sami; Arıbaş, Olgun Kadir; Akyol, Kazım; Demirci, Şerafettin; Ural, OnurKöpek ısırığına bağlı pnömotoraks oluşmuş bir vakada yapılacak acil tedavi ve adli işlemlerin vurgulanması amaçlandı. Olgu sunumu: Pnömotoraks tanısıyla 8 yaşında bir erkek çocuk tedavi edildi. Köpek ısırığına sekonder bir pnömotoraks vakası rapor edildi. Sonuç: Köpek ısırığına bağlı pnömotoraks nadir bir durumdur. Bu nedenle köpek ısırığı yaralanmalarının medikal ve adli boyutlarını literatür ışığında gözden geçirdik.Öğe Lower Extremity Deep Vein Thrombosis and its Treatment(Springer-Verlag, 1992) Solak, Hasan; Yeniterzi, Mehmet; Yüksek, Tahir; Özpınar, Cevat; Ceran, Sami; Ünal, A. ErkanStudies on venous thrombosis depend on Virchow's triad related to venous thrombosis. This triad includes stasis, coagulation defect, and vein wall lesion. Venous thrombectomy was applied first by LeRiche in 1927. In subsequent years, Fogarty, De Weese, and Edwards defined the basic rules of venous thrombectomy and medical treatment more thoroughly.Öğe Monostotic fibrous dysplasia (two cases report)(2012) Döngel, İsa; Bayram, Mehmet; Sapmaz, Feride; Ceran, SamiFibröz displazi kemiğin mezenkimal kökenli, normal kemiğin yapıca zayıf fibröz ve osseöz doku ile yer değiştirmesi sonucu oluşan lokalize iyi huylu gelişimsel bir ano-malisidir. Etiyolojisi tam olarak bilinmemektedir. Üç formu tanımlanmıştır, mo-nostotik fibröz displazi en çok görülen form olup olguların %70’ ini oluşturur, ço-ğunlukla ergenlik döneminde görülür ve kemik büyümesinin durması ile sakinleşir. Endokrin hastalıklarla birliktelik gösteren çok odaklı fibröz displazi en az görülen form olup olguların % 3-5’inin oluşturur. Kliniğimizde kemik gelişimini tamamla-mış, göğüs ağrısı şikayetleri ile başvuran ve izole tek kotta monostotik fibröz disp-lazi tanısı konulan, tanı ve tedavi amaçlı cerrahi olarak enbloc kot rezeksiyonu uy-gulanan iki hastayı literatür bilgileri eşliğinde sunmayı amaçladık.Öğe Multipl Primer Tümörler (I?ki Olgu Sunumu)(2001) Arıbaş, Olgun; Kanat, Fikret; Ceran, SamiAmaç: Akciğer kanserlerinin seyrinde metastazlar daha sık görülmekle birlikte ender rastlanılan multipl primer tümörlerin tanımlanması amaçlanmıştır. Olgu sunumu: Biri akciğer ve cilt altı, diğeri akciğer ve böbrek yerleşimli eşzamanlı olarak saptanan multipl primer tümörlü iki olgu sunuldu. Cerrahi rezeksiyon uygulanan olgulardan ilkinde histopatoloji; akciğerde adenokarsinom ile gluteal bölgede cilt altında miksoid liposarkom, ikincisinde ise akciğerde küçük hücreli karsinom ve böbrekteki hipernefroma idi. Tedaviyi takiben 1. olgu 20 aydır tümörsüz ve sağlıklı yaşamını sürdürürken 2. olguda ise adjuan kemoterapiyi takiben 16. ayda serebral ve multipl akciğer metastazları saptandı. Sonuç: Eşzamanlı saptanan bu tümörlerin gerek lokalizasyonları gerekse histopatolojik kombinasyonları dolayısıyla ender rastlanmaları nedeniyle, multipl primer tümörler literatür ışığında gözden geçirilmiştir.Öğe Myocardial Cystic Hydatids Causing Cardiac-Tamponade - Report of Cases(WESTMINSTER PUBL INC, 1991) Solak, Hasan; Yüksek, Tahir; Yeniterzi, Mehmet; Akkoç, Özkan; Anıl, Nazif; Ceran, SamiFour patients with cystic hydatids located in pericardium and myocardium were admitted. Cardiac tamponade was determined in 1 of these cases. Surgical treatment was instituted for all cases. Transpericardial cardiac palpation was emphasized in cases where thoracotomy was necessary due to the lung cystic hydatids.Öğe Nörojenik tümörü taklit eden nadir bir özofagus duplikasyon kisti: Olgu sunumu(2012) Döngel, İsa; Bayram, Mehmet; Metin, Bayram; Ceran, Sami; Sunam, Güven SadiGastrointestinal sistem (GİS) kaynaklı duplikasyon kisti, nadir görülen konjenital lezyonlardır. Gastrointestinal sistemin anormal kanalizasyonu sonucu oluşurlar. GİS boyunca herhangi bir yerde görülebilirler, fakat en sık sağ posterior mediastene yerleşirler. Tesadüfen çekilen PA akciğer grafisinde patoloji saptanan bayan hasta kliniğimize 20 yaşındaki yönlendirildi. Sağda ekstrapulmoner yerleşimli paravertebral bölgede, azygoözefageal resese uzanan kistik yapıdaki lezyon sağ torakotomi ile çıkarıldı. Histopatolojik tanısı özofagus duplikasyon kisti olarak raporlandı. Eşlik eden başka bir patoloji mevcut değildi. Bu çalışmada paravertebral yerleşimli kistik lezyonların ayırıcı tanısının yapılabilmesi ve literatür bilgileri eşliğinde duplikasyon kistinin değerlendirilmesi amaçlandı.Öğe Parabronchial Diverticulum of Esophagus: Report of a Case(DERMAN MEDICAL PUBL, 2015) Altuntaş, Bayram; Uyanıkoğlu, Ahmet; Ceran, Sami; Sunam, Güven Sadi; Metin, BayramParabronchial or midesophageal diverticulum is a saclike bulging of the midesophageal wall into the periesophageal space. This bulging usually occur secondary to mediastinal inflammation. We report a case of a midesophageal diverticulum in a 21-year-old man. We discuss midesophageal diverticulum and review the literature findings.