A comparison of the efficacies of heterologous blood, rifamycin, and talc as pleural sclerosants in rabbits: An experimental study
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada tavşanlarda rifamisin plörodezis etkinliği araştırıldı. Çalışma planı: Çalışmada ortalama ağırlıkları 3433 g olan toplam 21 adet erkek Yeni Zelanda türü albino tavşan kullanıldı. Bir adet tavşan kan temininde kullanıldı. Diğer 20 tavşan kontrol grubu, heterolog kan grubu, rifamisin grubu ve talk grubu olarak dört gruba ayrıldı. Tavşanlara gruplarına göre sol hemitoraksa takılan kateterden distile su, heterolog taze kan, rifamisin ve steril sıvı talk verildi. Yirmi sekizinci günde tavşanlar yüksek doz anestezi ile sakrifiye edildi. Plevrada makroskopik olarak plörodezis varlığı ve mikroskopik olarak plevral kalınlıkları ölçüldü ve inflamasyon ve fibrozis bulguları araştırıldı. Plörodezis derecesi 0’dan 4’e kadar olan skalada değerlendirildi. Bulgular: Makroskopik ve mikroskopik seviyede kontrol grubu ile heterolog kan grubu arasında istatistiksel olarak a nlamlı fark bulunmadı (p0.05). Talk ve rifamisin grubunda plörodezis derecesi kontrol ve heterolog kan grubundan daha yüksek idi (p0.04). Rifamisin grubu ile talk grubu arasında makroskopik ve mikroskopik incelemede anlamlı fark bulunmadı (p0.05). Plevral fibrozis kalınlığının medyan değerleri kontrol, heterolog kan, rifamisin ve talk grupları için sırasıyla 10 (10-29), 26 (10-71), 312 (264-351) ve 304 (238-331) ?m ölçüldü. Sonuç: Tavşanlarda rifamisin plörodezis etkinliği mikroskopik ve makroskopik olarak talk grubu ile benzer; kontrol ve heterolog kan grubuna göre daha üstün bulundu.
Background: In this study, we aimed to investigate the efficacy of rifamycin pleurodesis in rabbits. Methods: A total of 21 male New Zealand-type albino rabbits with an average weight of 3433 grams, were used in the study. One rabbit was used for blood supply. The other 20 rabbits were divided into four groups, including the control group, the heterologous blood group, the rifamycin group, and the talc group. Distilled water, heterologous fresh blood, rifamycin, and sterile liquid talc were administered through the catheter to the left hemithorax of rabbits. The rabbits were sacrificed using high-dose anesthesia on day 28. The pleural spaces were grossly assessed for evidence of pleurodesis and microscopic thickness of the pleura, and evidence of inflammation and fibrosis were examined. The degree of pleurodesis was rated on a scale of 0 to 4. Results: No statistically significant differences were observed between the control and heterologous blood groups at the macroscopic and microscopic level (p>0.05). The degree of pleurodesis in the talc and rifamycin groups was higher than in the control and heterologous blood group (p0.04). No significant difference was observed between the talc and rifamycin groups in terms of macroscopic and microscopic examination (p>0.05). The median values of fibrosis thickness of the control, heterologous blood, rifamycin, and talc groups were 10 (10-29), 26 (10-71), 312 (264-351) and 304 (238-331) μm, respectively. Conclusion: The efficacy of rifamycin pleurodesis in rabbits was microscopically and macroscopically similar to the talc group and superior to the control and heterologous blood group.
Background: In this study, we aimed to investigate the efficacy of rifamycin pleurodesis in rabbits. Methods: A total of 21 male New Zealand-type albino rabbits with an average weight of 3433 grams, were used in the study. One rabbit was used for blood supply. The other 20 rabbits were divided into four groups, including the control group, the heterologous blood group, the rifamycin group, and the talc group. Distilled water, heterologous fresh blood, rifamycin, and sterile liquid talc were administered through the catheter to the left hemithorax of rabbits. The rabbits were sacrificed using high-dose anesthesia on day 28. The pleural spaces were grossly assessed for evidence of pleurodesis and microscopic thickness of the pleura, and evidence of inflammation and fibrosis were examined. The degree of pleurodesis was rated on a scale of 0 to 4. Results: No statistically significant differences were observed between the control and heterologous blood groups at the macroscopic and microscopic level (p>0.05). The degree of pleurodesis in the talc and rifamycin groups was higher than in the control and heterologous blood group (p0.04). No significant difference was observed between the talc and rifamycin groups in terms of macroscopic and microscopic examination (p>0.05). The median values of fibrosis thickness of the control, heterologous blood, rifamycin, and talc groups were 10 (10-29), 26 (10-71), 312 (264-351) and 304 (238-331) μm, respectively. Conclusion: The efficacy of rifamycin pleurodesis in rabbits was microscopically and macroscopically similar to the talc group and superior to the control and heterologous blood group.
Açıklama
Anahtar Kelimeler
Cerrahi, Kalp ve Kalp Damar Sistemi
Kaynak
Türk Göğüs Kalp Damar Cerrahisi Dergisi
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
20
Sayı
3
