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Öğe Detection of REM in sleep EOG signals(Indian Society for Education and Environment, 2016) Coskun A.; Ozsen S.; Yucelbas S.; Yucelbas C.; Tezel G.; Kuccukturk S.; Yosunkaya S.Background/Objectives: Sleep staging is very important phase for diagnosing respiration and sleep diseases. Nowadays, Electroencephalogram (EEG), Electromyogram (EMG), Electrooculogram (EOG) signals are particularly used together in studies on sleep staging. Methods/Statistical Analysis: Associating only EOG signals to sleep staging was distinctly purposed. So, this paper deals with extraction features and classifying for determining REM-NREM states from the EOG signals. In this study, left eye (LEOG) and the right eye (REOG) signals were used. After EOG signals were obtained, 21 different features were extracted from LEOG and REOG in time and frequency domain according to rules of American Academy of Sleep Medicine (AASM). Findings: Artificial Neural Networks (ANN) was adopted on features as method of classification with 3-fold cross validation technique and reached conclusion with the maximum test classification accuracy as 88.05%. To obtain higher classification accuracies, Sequential Backward Selection (SBS) method was used. According to results of SBS, number of the best features combination was determined as 13 and the maximum classification accuracy was obtained as 89.62%. The optimum value of hidden layer node number of ANN was determined as 15 for the best features. Application/Improvements: When looking from the viewpoint of percentage of classification accuracy of this study, a result can be seen that is non-negligible value for literature.Öğe The levels of trace elements and macrominerals in calves with sepsis(Veteriner Fakultesi Dergisi, 2020) Coskun A.; Aydogdu U.; Guzelbektes H.; Sen I.The aim of this study was to determine the levels of macrominerals and trace elements in the blood of newborn calves with sepsis. The study was carried out on a total of 30 calves, aged 2-35 days old, of which 25 with sepsis and 5 healthy. In clinical examination, prolonged capillary refill time and tachypnea were observed in calves with sepsis. The levels of Cu, K, P and S in calves with sepsis were higher compared to the control group, and the levels of Na, total and ionized Ca, Fe and Zn were also lower compared to the control group. In conclusion, in this study, significant increase in K and Cu concentrations and significant decrease in Na and Ca concentrations were found in calves with sepsis. According to the results, K, Cu, Na and Ca may have important roles in the pathophysiology of sepsis. © 2020, Veteriner Fakultesi Dergisi. All rights reserved.Öğe Morphometric evaluation of the effect of methenolone enanthate on femoral development in adolescent rats(2011) Bozkurt I.; Pepe K.; Ozdemir M.; Ozdemir O.; Coskun A.The effect of Methenolone Enanthate (ME), one of the Anabolic-Androgenic Steroids (AAS), used as a muscle amplifier and for doping by athletes, on the femur bone development of adolescent male and female rats has been researched in this study. Three different groups for each male and female rat, including 8 rats of each, (ME, V, C) were formed and a total of 48 rats were used. The subject groups were given 0.5 mg/kg methenolone enanthate (Primobolan® Depot, Bayer) dilued in peanut oil, 0.5 ml; all animals received five intraperitonal injections weekly for four weeks. The rats were euthanized at the end of the four weeks and both femurs dissected and macerated. The length, corpus thickness, compact bone thickness and medulla canal diameter were measured with calipers and the average of each was noted. The effect of ME administration on femur length and corpus femoris thickness was negative in male animals but positive in females and was determined to be statistically significant (p<0.05) in both cases. There was no treatment-related difference in compact bone thickness and medulla diameter (p>0.05), while a significant difference (p<0.05) had been seen between the sexes in medulla diameter in the control groups. It was concluded that, the ME effect on rat femurs, similar to that of other AAS, consists in supressing bone growth in male animals while enhancing in females during pubertas. Rat models show negative middle-term and long-term effects of this agent, which is still widely in use as a performance enhancer, as opposed to its positive results in the short term. © 2011 Academic Journals.Öğe Morphometric evaluation of the effect of methenolone enanthate on humeral development in adolescent rats(2011) Bozkurt I.; Ozdemir M.; Pepe K.; Ozdemir O.; Coskun A.The effect of methenolone enanthate (ME), one of the anabolic-androgenic steroids (AAS), used as a muscle amplifier and for doping by athletes, on the humerus bone development of adolescent male and female rats has been researched in this study. Three different groups for each male and female rat, including 8 rats of each, (ME, V, C) were formed and a total of 48 rats were used. The subject groups were given 0.5 mg/kg methenolone enanthate (Primobolan® Depot, Bayer) diluted in peanut oil, 0.5 ml; all animals received five intraperitoneal injections weekly for four weeks. The rats were euthanized at the end of the four weeks and both humerus dissected and macerated. The length, corpus thickness, compact bone thickness and medulla canal diameter were measured with calipers and the average of each was noted. The effect of ME administration on humerus length and corpus femoris thickness was negative in male animals but positive in females and was determined to be statistically significant (p<0.05) in both cases. There was no treatment-related difference in compact bone thickness and medulla diameter (p>0.05), while a significant difference (p<0.05) had been seen between the sexes in medulla diameter in the control groups. Humerus compact bone density in male rats and medulla canal diameter of female rats are significant in terms of the difference between groups (p<0.05), and gender effect on the change arising in medulla canal diameter as a result of ME administration has been revealed to be insignificant (p>0.05). It was concluded that the ME effect on rat humerus, similar to that of other AAS, consists in supressing bone growth in male animals while enhancing it in females during puberty. Rat models show negative middle-term and long-term effects of this agent, which is still widely in use as a performance enhancer, as opposed to its positive results in the short term. ©2011 Academic Journals.Öğe Serum gastrin in dogs with acute or chronic gastritis and positive or negative for Helicobacter sp. in the stomach(2008) Guzelbektes H.; Coskun A.; Ortatatli M.; Sen I.The relationship between gastrin levels and presence of Helicobacter-like organisms (HLO) in dogs with acute or chronic gastritis was investigated. For this purpose, a total of 52 crossbred Kangal Dogs aging 2-5 years were used; including 12 dogs with acute gastritis, 25 dogs with chronic gastritis, and 15 healthy dogs. Blood samples were collected from the vena cephalica. Serum gastrin levels were measured using commercial competitive binding radioimmunoassay. HLO were found in 64%, 58.3%, and 60% of animals with chronic gastritis or acute gastritis, and controls, respectively. The gastrin levels in dogs with chronic gastritis were higher than in those with acute gastritis and controls. There were no significant differences between the gastrin levels in all groups, with regard to HLO positive versus HLO negative dogs. In conclusion, HLO incidence was generally found in high levels in all the dogs. However, HLO did not primarily affect the stomach mucosal damage. In the mean time, there was no relation between the levels of serum gastrin in dogs with gastritis, either being HLO positive or negative. The results of the study showed that higher gastrin levels in dogs with gastritis were related to severe gastric lesions and mucosal damage.
