Morphometric evaluation of the effect of methenolone enanthate on femoral development in adolescent rats
Küçük Resim Yok
Tarih
2011
Yazarlar
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Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The effect of Methenolone Enanthate (ME), one of the Anabolic-Androgenic Steroids (AAS), used as a muscle amplifier and for doping by athletes, on the femur bone development of adolescent male and female rats has been researched in this study. Three different groups for each male and female rat, including 8 rats of each, (ME, V, C) were formed and a total of 48 rats were used. The subject groups were given 0.5 mg/kg methenolone enanthate (Primobolan® Depot, Bayer) dilued in peanut oil, 0.5 ml; all animals received five intraperitonal injections weekly for four weeks. The rats were euthanized at the end of the four weeks and both femurs dissected and macerated. The length, corpus thickness, compact bone thickness and medulla canal diameter were measured with calipers and the average of each was noted. The effect of ME administration on femur length and corpus femoris thickness was negative in male animals but positive in females and was determined to be statistically significant (p<0.05) in both cases. There was no treatment-related difference in compact bone thickness and medulla diameter (p>0.05), while a significant difference (p<0.05) had been seen between the sexes in medulla diameter in the control groups. It was concluded that, the ME effect on rat femurs, similar to that of other AAS, consists in supressing bone growth in male animals while enhancing in females during pubertas. Rat models show negative middle-term and long-term effects of this agent, which is still widely in use as a performance enhancer, as opposed to its positive results in the short term. © 2011 Academic Journals.
Açıklama
Anahtar Kelimeler
AAS, Athletes, Bone, Methenolone enanthate, Morphometric, Rat
Kaynak
Scientific Research and Essays
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
6
Sayı
7
