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    Combined usage of testosterone and nandrolone may cause heart damage
    (ACADEMIC JOURNALS, 2011) Tasgin, Erdal; Lok, Sefa; Demir, Nagehan
    The aim of this study is to determine the effects of combined application of testosterone and nandrolone on male rabbits during adolescence period for biochemical values which are indicators of damage to heart, liver and kidney. Seven male New Zealand white rabbits, 60-days old, were used in this study. Testosterone (10 mg/kg) + nandrolone deconoate (10 mg/kg) were injected simultaneously to the rabbits in an intramuscular manner once in 1 week for a period of 12 weeks. Blood samples were taken in 0, 4, 8 and 12 weeks. Serum creatine kinase-MB, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl-transferase, creatinine and blood urea nitrogen were measured with an auto-analyzer. Combined use of testosterone and nandrolone caused (p < 0.05) increase in serum creatine kinase-MB activity, but no statistical changes (p > 0.05) were determined in other parameters. As a result, it can be concluded that the use of testosterone plus nandrolone simultaneously during early ages may cause heart damage.
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    The Effect of Testosterone Used in Sportsmen on Routine Biochemical Parameters
    (MEDWELL ONLINE, 2010) Taşgın, Erdal; Lok, Sefa; Demir, Nagehan; Özdemir, Mehmet
    The purpose of the research was to determine indicators of testosterone implication on heart, liver and kidney failure in female rats during puberty and also to determine its effect on some other chemical values. In the research, female 16 Sprague dawley rats (50 days) were used. The rats were divided into two equal groups. The first group was administrated testosterone, diluted with olive oil, 5 mg kg(-1) (SID) subcutaneously for 10 weeks, 5 days each week. The second group was only given olive oil. Serum creatine kinase, creatine kinase-MB, alkaline phosphates, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, triglyceride, cholesterol, high density lipoprotein, amylase, total protein, albumin and calcium were measured with an auto-analyzer. It was determined that while testosterone application in female rats leads to decrease on the total serum protein and albumin levels (p<0.05), it increased aspartate aminotransferase and cholesterol levels (p<0.05). Consequently, it can be stated that long term testosterone implication during puberty may lead to organ defects at early ages.
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    Effects of single dose administered nandrolone decanoate on serum cytokine levels and some biochemical parameters in male and female rats.
    (SCIENTIFIC PUBLISHERS INDIA, 2017) Tasgin, Erdal; Lok, Sefa; Haliloglu, Seyfullah; Demir, Nagehan; Ergin, Hale
    The aim this this study was to determine that administration of single higher dose nandrolone decanoate (40 mg/kg) on serum IL-1 beta, TNF-alpha, IL-10 and IL-6 levels and some biochemical parameters during 24 h in male and female rats. The blood samples were taken from 5 male and female rats to obtain their starting values. Then the blood samples were taken from 6 rats in sampling time at 1st, 2nd, 4th, 8th, 12th and 24th h following the nandrolone decanoate administration. There were significant increases determined in the serum IL-1 beta levels, numerical increases in the TNF-alpha levels whereas decreased IL-6 levels were determined. IL-10 levels did not change during experimental period. While serum GGT and BUN levels increased towards the last h of the study, increased ALP levels were observed only female rats. There was no any significance changes were determined in the other biochemical (ALT, AST, CK-MB and LDH) values. As a result, increased IL-1 beta and TNF-alpha levels, proinflammatory cytokines, and some biochemical parameters may be reflect that long term used nandrolone decanoate causes organ damages and effect immune system function. However, effects of long term used nandrolone decanoate on the immune system and organ functions should be detailed evaluated.
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    Long Term Used Testosterone May Cause Heart and Liver Damage
    (MEDWELL ONLINE, 2010) Lok, Sefa; Taşgın, Erdal; Demir, Nagehan; Özdemir, Mehmet
    The purpose of the research is to define the effects of testosterone on heart, liver, kidney and some chemical values in male rats during puberty In the research 16 Sprague dawley rats, 50 days old were used The rats were divided into two equal groups The first group was administrated testosterone, diluted with olive oil, 5 mg kg(-1) (SID) subcutaneously for 10 weeks 5 days each week The second group was only given olive oil At the end of the 10th week blood samples were taken Serum creatine kinase, creatine kinase-MB, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, triglyceride, cholesterol, high density lipoprotein, amylase, total protein, albumin and calcium were measured with an auto-analyzer It was determined that while testosterone application in male rats led to increase on the serum CK-MB, CK and AST levels (p<0 05), it caused decreases on the total protein, albumin, calcium and creatinine (p<0 05) As a result, it can be stated that long term testosterone implication during puberty may lead to heart and liver defects at early ages.