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    Effect of Phenobarbital on Antioxidant Enzyme Activities and Blood Gas Parameters in Balb/C Mice
    (ECOLE NATIONALE VETERINAIRE TOULOUSE, 2001) Demir, O.; Yazar, Enver; Altunok, Vahdettin; Elmas, Muammer; Özdemir, Vural
    In this study, effect of Phenobarbital was investigated on antioxidant enzyme activities and blood gas parameters in Balb/C mice. Forty male Balb/C mice were used. Ten mice were served as a control group, and thirty mice were administered phenobarbital (80 mg/kg body weight, orally, single administration). Blood, brain and liver samples were taken at 6, 12 and 24 hours after administration. Brain and liver tissues superoxide dismutase and glutathione peroxidase activities were measured by spectrophotometry, and blood gas parameters were measured with blood gas analyzer. As results, phenobarbital caused temporary respiratory acidosis and a decrease in brain tissue superoxide dismutase activity.
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    N-Hexane-Toluene Neuropathy in Shoe-makers
    (2001) Demir, O.; Akpınar, Z.; Demireli, O.
    n-Hexane and toluene are solvents commonly used as glue in the shoe industry and the two substances are synergistic. The development of neuropathy in people subjected to inhalation of these substances were reported by some investigators. In the present study we investigated evidence of clinical and subclinical polyneuropathy in 56 shoe industry workers who have been working in bad ventilated workshops for 3-30 years. None of them had clinical evidence of neuropathy, but they had decreased sensory conduction velocities and amplitudes. Distal motor latencies were prolonged when compared to the control group (p<0.001). Motor conductions were not found to be affected (p>0.05). Development of neuropathy was not directly correlated to duration of exposure of the solvents (p>0.05). We concluded that subclinical peripheral neuropathy developed in subjects who were exposed to inhalation of n-hexane and toluene. Preventing them from working in insufficiently ventilated workshops is of importance from aspects of preventive medicine.
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    Phenobarbital Effects on Brain and Liver Tissues Enzyme Activity in Balb/c Mice
    (VYSOKA SKOLA VETERINARNI FARMACEUTICKA, 2002) Yazar, Enver; Demir, O.; Elmas, Muammer; Baş, Ahmet Levent; Traş, Bünyamin
    The purpose of the present study was to investigate the effect of phenobarbital on some brain and liver tissue enzyme activities in Balb/C mice. Forty male Balb/C mice were used. Ten mice served as a control group, and thirty mice were administered with phenobarbital (80 mg(.)kg(-1) body mass, single oral dose). Brain and liver samples were taken at 6, 12 and 24 h after drug, administration. Brain and liver tissues alkaline phosphatase, aspartate aminotransferase, gamma glutamyl transferase and amylase activities were measured by autoanalyzer. Phenobarbital did not affect gamma glutamyl transferase and amylase activities in the brain and liver, and alkaline phosphatase and aspartate aminotransferase activities in the liver. However, statistically significant (p < 0.05) increases of alkaline phosphatase and aspartate aminotransferase activities were observed in the brain. In general, after phenobarbital administration, serum alkaline phosphatase and aspartate aminotransferase activities increase and these increases are believed to be derived from the liver. These result suggest that brain may contribute to increased activities of these enzymes in serum in Balb/C mice.
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    The Utility of Dermatomal Somatosensory Evoked Potentials (Dseps) in Diagnosis and Prognosis of The Unilateral Lumbosacral Radiculopathy Due to Herniated Intervertebral Disc
    (1995) Özerbil, O. M.; Demir, O.; Oğuz, H.; Genç, B. O.; Yel, M.
    In this study, determination of the utility of DSEPs in patients with unilateral lumbosacral radiculopathy due to herniated intervertebral disc for diagnosing, planning the management and obtaining information about prognosis was purposed. Scalp-recorded somatosensory evoked potentials to electrical stimulation in L5 and S1 dermatomes in 31 patients and 26 normal subjects were examined. Abnormal DSEP recordings were obtained by comparing with normal values derived from studies of normal subjects. DSEP recordings were compared with the results of computed tomography and electromyographic studies of the same patients. All of the patients had conservative therapy, and physical examination and DSEP studies of 23 patients were reevaluated after three months and improvement of the clinical and DSEP findings were compared in each patient. DSEP sensitivity of 31 patients is 77.4 %. Absent responses were associated with acute lesions and with low back pain in extension. DSEP findings after three months perfectly reflected either clinical improvement or continuation of symptoms and clinical findings. It was concluded that, (1) there is no superiority of DSEP to the other studies in identifying unilateral lumbosacral radiculopathy due to herniated intervertebral disc, if technical and interpretational differences are removed, diagnostic utility of DSEPs will increase (2) DSEPs have a prognostic utility to follow the patients' courses.