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    Evaluating nail thickness and stiffness with shear-wave elastography in nail psoriasis: A preliminary study
    (WILEY, 2020) Islamoğlu, Zeynep Gizem Kaya.; Uysal, Emine.; Demirbaş, Abdullah.; Islamoğlu, Necat.
    Introduction Psoriasis is a chronic, relapsing skin disease affecting millions of people worldwide. Nail changes have been reported to occur in up to 40% of patients with mild psoriasis and 50%-70% with severe disease. Shear-wave elastography (SWE) is a new non-invasive ultrasonic technique that evaluates thickness and stiffness of tissues. Aims To evaluate nail plate thickness and stiffness of patients with psoriasis and determine whether there are differences among psoriatic patients with and without nail involvement, and to investigate the feasibility of using SWE in assessing this disease. Materials and Methods Nail plate thickness and stiffness were investigated in 54 patients with psoriasis and 58 healthy controls. SWE was performed with an Aplio 500 ultrasound system. Results Increased nail plate thickness was observed more often in the affected nails of psoriatic patients compared to non-affected nails of patients and controls. Stiffness was similar in both groups. Conclusions Our study is the first report to evaluate the SWE scores in nail psoriasis. While it may not provide reliable information for diagnosis, it can be used for follow-up treatment.
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    Evaluation of complete blood cell and inflammatory parameters in patients with alopecia areata: Their association with disease severity
    (WILEY, 2019) Kaya İslamoğlu, Zeynep Gizem.; Demirbaş, Abdullah.
    Background Alopecia areata (AA) is a chronic inflammatory disease characterized by non-cicatricial hair loss. The cause of the disease is still unknown. It can appear at any age and occurs in 0.2% of the general population. Red cell distribution width (RDW), mean platelet volume (MPV), plateletcrit (PCT), the ratio of neutrophils to lymphocytes (NLR), and the ratio of platelets to lymphocytes (PLR) have all been reported as inflammatory markers in recent studies. However, these parameters have not been investigated in AA patients. Aim We investigated the haematological and inflammatory parameters of AA and considered their association with disease severity. Patients/Methods One hundred and five patients with AA and 108 healthy controls were enrolled in the study. RDW, MPV, PCT, NLR, PLR, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were studied retrospectively. Disease severity was evaluated by using the Severity of Alopecia Tool (SALT) score. Results There were no statistically significant differences between RDW, MPV, PCT, NLR, and PLR levels in AA patients and in healthy controls. Only the CRP values were significantly higher in the AA group. Conclusion Complete blood count (CBC) parameters are low-cost tests that can be used to define inflammation levels in inflammatory diseases. Our study shows that CRP can be used as a marker in diagnosing AA.