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Öğe Analysis of 24-hour heart rate variations in patients with epilepsy receiving antiepileptic drugs(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011) Yildiz, Gulce Unal; Dogan, Ebru Apaydin; Dogan, Umuttan; Tokgoz, Osman Serhat; Ozdemir, Kurtulus; Genc, Bulent Oguz; Ilhan, NurhanObjective: The goal of the study described here was to evaluate interictal heart rate variability (HRV) in young patients with epilepsy, a patient population in whom sudden unexpected death in epilepsy (SUDEP) is known to be more common. Methods: Twenty-four-hour ambulatory ECG Holter recordings of 37 patients (15-40 years old) and 32 healthy controls were compared. Results: All of the time domain indices (SDNN, SDANN, RMSSD, and HRV triangular index) were significantly suppressed (P < 0.001), and there was a marked reduction in parasympathetic tone (reduced HFnu, P < 0.001) and an increase in sympathetic tone (increased LFnu and LF/HF ratio, P < 0.001) in the patient group. Stepwise linear regression analysis revealed that polytherapy and epilepsy duration > 10 years were independent variables associated with a reduction in SDNN. Conclusion: Our data suggest that the major determinants of suppressed SDNN are polytherapy and epilepsy duration > 10 years. Analysis of spectral measures of frequency domain indices suggests that an increased sympathetic tone in association with a decreased parasympathetic tone may constitute the mechanism underlying SUDEP in young people with epilepsy. (C)2010 Elsevier Inc. All rights reserved.Öğe A Case With Prepontine (Clival) Arachnoid Cyst Manifested as Trigeminal Neuralgia(WILEY-BLACKWELL, 2008) Genc, Emine; Dogan, Ebru Apaydin; Kocaogullar, Yalcin; Emlik, Dilek(Headache 2008;48:1525-1539) Most cases of "idiopathic" trigeminal neuralgia are thought to originate from vascular compression of the trigeminal root entry zone. In this case, we describe a young man presenting with the symptoms of trigeminal neuralgia associated with a prepontine (clival) arachnoid cyst.Öğe Concomitant neuromyelitis optica and cytomegalovirus-associated retinitis in an immunocompetent female(SPRINGER HEIDELBERG, 2014) Tokgoz, Serhat; Dogan, Ebru Apaydin; Gumus, Haluk; Ilhan, Nurhan; Ural, Onur[Abstract not Available]Öğe Effect of Musical Training on Auditory Event Related Potentials N200 (Mismatch Negativity) and P300(ORTADOGU AD PRES & PUBL CO, 2009) Genc, Emine; Yagisan, Nihan; Dogan, Ebru Apaydin; Genc, Bulent OguzObjective: Studies with endogenous event related potentials, demonstrated that musical training influenced auditory brain functions. The aim of the present study was to investigate whether auditory event related potentials (ERPs)-mismatch negativity (MMN) and P300-differ between musically trained and musically lay subjects. Material and Methods: MMN and P300 were recorded in 19 musically trained (mean age 20.2 +/- 2.38 years) and in 17 musically lay subjects (20.76 +/- 1.75 years) using an "oddball paradigm". 20% of stimuli were rare (target) tones of 2000 Hz, whereas the remainder was frequent (non-target) tones of 1000 Hz. Subjects were instructed to press a button when they encountered the rare stimuli. Latencies and amplitudes of auditory MMN and P300 responses obtained from musically trained subjects were compared to those obtained from musically lay subjects. Results: In musically trained subjects, MMN latencies were significantly decreased while MMN amplitudes did not differ between the 2 groups. P300 latencies and amplitudes did not differ between musically trained and musically lay subjects. Conclusion: Decreased latencies of MMN in musically trained subjects suggest that musical training might influence pre-attentive auditory processing and auditory sensory memory mechanisms can be modulated by musical experience. It is possible that electrophysiological responses obtained from musicians reflect structural adaptations in response to long term music training.Öğe Long-Term Effects of Valproic Acid on Reproductive Endocrine Functions in Turkish Women with Epilepsy(KARGER, 2009) Gorkemli, Huseyin; Genc, Bulent Oguz; Dogan, Ebru Apaydin; Genc, Emine; Ozdemir, SunaThe long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied. Serum reproductive hormone concentrations, clinical findings and ovarian morphology were analyzed in 71 WWE who had been receiving antiepileptic drugs (AED) for a minimum of 2 years. Of the 71 WWE, polycystic ovarian syndrome (PCOS) (p = 0.011) and menstrual irregularities (p = 0.009) were found to be more prevalent in women receiving VPA treatment when compared to women on non-VPA treatment. There was no statistically significant dose or duration-related rise of risk for patients who developed PCOS and menstrual irregularities and those who were not on long-term VPA therapy. The lack of a duration-related reproductive dysfunction in this patient population may support the hypothesis of early occurring VPA-associated metabolic and endocrine changes. Copyright (C) 2009 S. Karger AG, BaselÖğe Lumboperitoneal shunt in a patient with Behcet's disease with medically refractory intracranial hypertension(ELSEVIER SCI LTD, 2011) Dogan, Ebru Apaydin; Ozturk, Banu Turgut; Mutluer, Muzaffer; Yildiz, Gulce Unal; Genc, Emine; Yuruten, Betigul; Kocaogullar, YalcinA 21-year-old male presented with severe throbbing headache, nausea, vomiting and progressive visual loss. Clinical examination revealed bilateral papilledema and left abducens nerve palsy. MRI showed findings consistent with ducal sinus thrombosis. Combinging the clinical findings, MRI and a positive pathergy test, the patient was diagnosed with dural sinus thrombosis associated with Behcet's disease (BD). Despite acetazolamide, prednisone, azathioprine and repeated lumbar punctures, his signs and symptoms of intracranial hypertension gradually worsened. Therefore, lumboperitoneal shunting was planned after which rapid resolution of intracranial hypertension was observed. After reviewing similar reports, we suggest that lumboperitoneal shunt placement can be an effective treatment for patients with BD with medically refractory intracranial hypertension associated with dural sinus thrombosis. (C) 2010 Elsevier Ltd. All rights reserved.Öğe Spinal myoclonus associated with vitamin B12 deficiency(ELSEVIER, 2007) Dogan, Ebru Apaydin; Yuruten, BetigulWe report a 85-year-old female patient with involuntary and regular movements restricted to abdominal muscles, resembling belly dance, with additional clinical features; ataxia, impaired cognition, neuropathy and glossitis. We initially excluded the possible cortical and spinal structural abnormalities with magnetic resonance imagings and performed routine blood analysis which revealed that serum vitamin B12 (vB12) level was under normal ranges. The relation of low serum vB12 level and myoclonus is speculative and very few studies have demonstrated such patients. In this case report, serum vB 12 deficiency is discussed in the context of its probable role in the generation of spinal myoclonus. (C) 2007 Elsevier B.V. All rights reserved.
