Long-Term Effects of Valproic Acid on Reproductive Endocrine Functions in Turkish Women with Epilepsy
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
KARGER
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied. Serum reproductive hormone concentrations, clinical findings and ovarian morphology were analyzed in 71 WWE who had been receiving antiepileptic drugs (AED) for a minimum of 2 years. Of the 71 WWE, polycystic ovarian syndrome (PCOS) (p = 0.011) and menstrual irregularities (p = 0.009) were found to be more prevalent in women receiving VPA treatment when compared to women on non-VPA treatment. There was no statistically significant dose or duration-related rise of risk for patients who developed PCOS and menstrual irregularities and those who were not on long-term VPA therapy. The lack of a duration-related reproductive dysfunction in this patient population may support the hypothesis of early occurring VPA-associated metabolic and endocrine changes. Copyright (C) 2009 S. Karger AG, Basel
Açıklama
Anahtar Kelimeler
Polycystic ovarian syndrome, Reproductive dysfunction, Valproic acid, Epilepsy
Kaynak
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
67
Sayı
4
