Long-Term Effects of Valproic Acid on Reproductive Endocrine Functions in Turkish Women with Epilepsy

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dc.contributor.authorGorkemli, Huseyin
dc.contributor.authorGenc, Bulent Oguz
dc.contributor.authorDogan, Ebru Apaydin
dc.contributor.authorGenc, Emine
dc.contributor.authorOzdemir, Suna
dc.date.accessioned2020-03-26T17:39:09Z
dc.date.available2020-03-26T17:39:09Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied. Serum reproductive hormone concentrations, clinical findings and ovarian morphology were analyzed in 71 WWE who had been receiving antiepileptic drugs (AED) for a minimum of 2 years. Of the 71 WWE, polycystic ovarian syndrome (PCOS) (p = 0.011) and menstrual irregularities (p = 0.009) were found to be more prevalent in women receiving VPA treatment when compared to women on non-VPA treatment. There was no statistically significant dose or duration-related rise of risk for patients who developed PCOS and menstrual irregularities and those who were not on long-term VPA therapy. The lack of a duration-related reproductive dysfunction in this patient population may support the hypothesis of early occurring VPA-associated metabolic and endocrine changes. Copyright (C) 2009 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000203537en_US
dc.identifier.endpage227en_US
dc.identifier.issn0378-7346en_US
dc.identifier.issn1423-002Xen_US
dc.identifier.issue4en_US
dc.identifier.pmid19246930en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage223en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000203537
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23658
dc.identifier.volume67en_US
dc.identifier.wosWOS:000265865200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofGYNECOLOGIC AND OBSTETRIC INVESTIGATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPolycystic ovarian syndromeen_US
dc.subjectReproductive dysfunctionen_US
dc.subjectValproic aciden_US
dc.subjectEpilepsyen_US
dc.titleLong-Term Effects of Valproic Acid on Reproductive Endocrine Functions in Turkish Women with Epilepsyen_US
dc.typeArticleen_US

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