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Öğe THE EFFECTS OF AFLATOXIN AND GLUCOMANNAN ON SOME ANTIOXIDANTS AND BIOCHEMICAL PARAMETERS IN RABBITS(VETERINARY FACULTY, UNIV BEOGRADU, 2008) Donmez, N.; Keskin, E.In this study the effects of aflatoxin added to the feed and the effects of glucomannan supplemented in order to prevent aflatoxin absorbtion on some biochemical parameters and antioxidants were studied in 40 New Zeland rabbits. The rabbits were randomly alloted to the following groups: control (C), glucomannan (G), glucomannan + aflatoxin (AG) and aflatoxin (A). At the end of the ten weeks trial MDA levels increased, GSH and SOD levels were decreased (p<0.05) in group A compared with control group levels. Cholesterol, glucose, albumin and total protein levels also decreased, AST and ALT levels were increased in group A compared with the control group. In the group G the former parameters were not affected by glucomannan application alone. On the other hand in the AG group MDA, GSH, SOD, cholesterol, glucose, albumin and total protein levels were higher, while AST and ALT levels were lower compared with the control levels, although these differences were not significant. In conclusion, the results determined in the study might be important to demonstrate the effects of aflatoxicosis on some biochemical and antioxidant parameters.Öğe The effects of protein deficiency on Na, K-ATPase activity in rat kidney(INDIAN VETERINARY JOURNAL, 2008) Donmez, N.; Beige, F.; Yur, F.; Tatar, M.Protein restriction has a therapeutic effect on spontaneously occruing autoimmune diseases related to the kidney. Some researchers have described the benefits of a low-protein diet in reducing proteinuria and slowing the decline of renal function in patients with insulin-dependent diabetes (Bossola et al., 2005) or nondiabetic proteinuric glomerulopathies (Ruggenenti and Remuzzi, 2000). In the present study, the effects of various levels of protein deficiency on NaK-ATPase enzyme activity and cholesterol levels of renal extractions were examined.Öğe Effects of traditional homemade koumiss on some hematological and biochemical characteristics in sedentary men exposed to exercise(TAYLOR & FRANCIS LTD, 2014) Donmez, N.; Kisadere, I.; Balaban, C.; Kadiralieva, N.We evaluated the effects of koumiss on some hematological and biochemical characteristics of persons who exercise. Eighteen sedentary males were assigned to three equal groups: koumiss (K), koumiss + exercise (KE) and exercise alone (E). Leukocytes (WBC), differential leucocyte count, erythrocytes (RBC), hemoglobin (HGB), hematocrit (HCT), platelet (PLT), glucose, total cholesterol, triglycerides, high density lipoprotein (HDL), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were assessed In blood samples. By the end of the study, triglycerides (TG) and cholesterol levels tended to decrease in all groups, but the decrease was significant only at day 15 for the KE group. HDL tended to be increased in all groups at day 15, but the increase was signifi cant only in the KE group. We found that koumiss had beneficial effects on some hematological and biochemical characteristics.Öğe The protective effect of L-carnitine against hippocampal damage due to experimental formaldehyde intoxication in rats(INFORMA HEALTHCARE, 2014) Ozmen, E.; Ozsoy, S. Y.; Donmez, N.; Ozsoy, B.; Yumusak, N.We investigated the protective effects of L-carnitine on hippocampus tissue damage in rats during experimental formaldehyde (FA) intoxication. Male Wistar albino rats were assigned into four groups: (1) control (C), (2) formaldehyde (FA), (3) formaldehyde + 0.5 g/kg of L-carnitine (FA + 0.5 LC) (4) formaldehyde + 1 g/kg L-carnitine (FA + 1 LC). At the end of the 14 day trial period, animals were sacrificed by decapitation under anesthesia. The hippocampus tissue samples were extracted to measure MDA, GSH and SOD activity. Neuronal degeneration was assessed based on histopathological (hematoxylin and eosin) and immunohistochemical (anti-ubiquitin) examination. To detect oxidative stress, specimens were reacted with anti-Cu/Zn-SOD antibody. After administering L-carnitine with FA to the animals, the activities of SOD and GSH increased, but the levels of MDA decreased in hippocampus tissue. Neuronal degeneration was observed in the FA group. L-carnitine administration reduced neuronal degeneration and histological structure was similar to controls. After FA application, degenerated hippocampus neurons were stained with anti-ubiquitin and Cu/Zn-SOD antibodies; weakly positive staining was observed in L-carnitine-treated groups. L-carnitine may be useful for preventing oxidative damage in the hippocampus tissue due to formaldehyde intoxication.Öğe Protective effect of quercetin on some hematological parameters in rats exposed to cadmium(TAYLOR & FRANCIS LTD, 2019) Donmez, H. H.; Donmez, N.; Kisadere, I.; Undag, I.We investigated the effects of quercetin (Q) on some hematological parameters and determined the percentage of alpha-naphthyl acetate esterase (ANAE) positive lymphocytes in rats that had been exposed to cadmium (Cd). Thirty male Wistar albino rats were divided into four groups: control (C), quercetin (Q), cadmium (Cd) and Q + Cd (CdQ). Blood samples were taken to assess erythrocytes (RBC), leukocytes (WBC), hemoglobin levels (Hb), hematocrit values (Hct), platelets (PLT), alpha-naphthyl acetate esterase (ANAE) positive lymphocytes. RBC, Hb, Hct; the number of PLT significantly decreased in the Cd group. To the contrary, these parameters were increased significantly in the CdQ group compared to the Cd group. Although we found a significant increase in total WBC count and neutrophil percentage, the number of lymphocytes decreased in the Cd group compared to the other three groups. Also, the percentage of peripheral blood ANAE positive lymphocytes decreased significantly in the Cd group (p < 0.05). Q exhibits positive effects on some hematological characteristics and the percentage of ANAE positive lymphocyte in cases of acute CD toxicity.