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    Are Symptoms of Gastroesophageal Reflux in Children Associated with Diagnoses of Endoscopic and/or Histological Esophagitis?
    (ORTADOGU AD PRES & PUBL CO, 2012) Emiroglu, Halil Haldun; Sokucu, Semra; Gulluoglu, Mine; Cantez, Serdar; Camlica, Hakan; Durmaz, Ozlem
    Objective: The purpose of this study was to find out whether symptoms in children suspected to have gastroesophageal reflux disease are correlated with the endoscopic and/or histological diagnoses of esophagitis. Material and Methods: The data of 140 children [mean age 8.9 +/- 4.6 (0.16-18) years] who underwent diagnostic upper endoscopy and biopsy of distal esophagus were collected between January 2002 and December 2004. Endoscopic findings were classified according to the Los Angeles system. Histopathological findings were classified according to Knuff & Leape classification. The relationship between symptoms and the diagnoses of endoscopic or histological esophagitis was examined retrospectively. Results: Twenty nine patients (20.7%) had endoscopic esophagitis and 51(36.4%) had histological reflux esophagitis. Prevalence of erosive reflux disease was 12.1 %, and that of non-erosive reflux disease was 24.3%. The symptoms suggesting gastroesophageal reflux did not have a statistically significant correlation with endoscopic or histological esophagitis. Conclusion: The diagnostic value of symptoms in children suspected to have gastroesophageal reflux disease are low. Regardless of the symptoms of gastroesophageal reflux, collecting biopsy samples from esophagus still seems to be a beneficial approach both in children undergoing diagnostic upper endoscopy when there is no contraindication for obtaining a biopsy.
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    Bilateral Cytomegalovirus Retinitis in a Child with Rhabdomyosarcoma
    (KARE PUBL, 2017) Zulfikar, Osman Bulent; Emiroglu, Halil Haldun; Kebudi, Rejin; Emiroglu, Melike; Tuncer, Samuray
    Reactivation of cytomegalovirus (CMV) leading to retinitis has been commonly reported in association with human immunodeficiency virus (HIV) infection or iatrogenic suppression of the immune system, including transplant recipients. Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in the pediatric age group, and alveolar histology is associated with unfavorable outcome. Presently described is case of RMS with alveolar histology in a 12-year-old male who developed CMV bilateral retinitis during prolonged period of neutropenic fever after 40 weeks of chemotherapy. He was diagnosed based on CMV-DNA polymerase chain reaction in blood and urine samples, and responded well to intravenous gancyclovir treatment. A high index of suspicion for reactivation of CMV leading to retinitis should be maintained and, if needed, investigated, not only in patients with HIV infection or transplant recipients, but also all patients who are iatrogenically immunosuppressed, including those who experience prolonged neutropenic fever due to lengthy courses of radiotherapy and chemotherapy.
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    Infliximab therapy for inflammatory colitis in an infant with NEMO deficiency
    (HUMANA PRESS INC, 2019) Artac, Hasibe; Emsen, Ayca; Ucaryilmaz, Hulya; Emiroglu, Halil Haldun; Uygun, Vedat; Stray-Pedersen, Asbjorg
    [Abstract not Available]