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  • Küçük Resim Yok
    Öğe
    Akut apandisitte iskemi modifiye albümin
    (2012) Bostancı, Hasan; Kurban, Sevil; Erbay, Ekrem; Köksal, Hande
    Amaç: Akut apandisitli (AA) hastalarda iskemi modifiye albumin (İMA) düzeyinin saptanması ve prognostik öneminin değerlendirilmesidir. Yöntem ve Gereçler: AA tanısı alan 61 hasta (K/E: 32/29) ile sağlıklı 30 kişi (K/E: 17/13) çalışmaya dahil edildi. Çalışma grubunda kan örnekleri ameliyat öncesi dönemde alındı. İMA düzeyleri kalorimetrik yöntemle ölçüldü ve sonuçlar absorbans ünitesi (ABSU) cinsinden rapor edildi. Bulgular: Akut apandisitli hastalar ile kontrol grubunun İMA değerleri sırası ile 0,420,17 ABSU ve 0,370,13 ABSU idi. Hasta grubunda İMA değeri kontrol grubuna göre daha yüksek olmasına karşın aradaki fark istatistiksel olarak anlamlı değildi (p0,05). Yakınma süresi uzun olan, lökositozu ya da nötrofilisi olan hastalarda serum İMA düzeyi daha yüksek olmasına karşın aradaki farklar istatistiksel olarak anlamlı değildi (p0,05). Ancak, perfore AA’li hastaların serum İMA düzeyleri diğer alt gruplardan daha yüksek bulundu (p0,001). Sonuç: AA’de inflamasyona bağlı olarak serum İMA düzeyinde yükseklik olmasına karşın, lümen içi basınç artışı, ödem, inflamasyon ve apendiks dokusunun beslenme bozukluğunun maksimum olduğu perfore AA’li hastalarda serum İMA düzeyinin daha yüksek olduğu gözlendi.
  • Küçük Resim Yok
    Öğe
    Serum ischemia-modified albumin and oxidized LDL in cord blood and serum of neonates born to pre-eclamptic mothers
    (WILEY, 2015) Mehmetoğlu, İdris; Kurban, Sevil; Toker, Aysun; Annagür, Ali; Altunhan, Hüseyin; Erbay, Ekrem; Örs, Rahmi
    BackgroundWe investigated oxidized low-density lipoprotein (OxLDL) and ischemia-modified albumin (IMA) in cord blood and neonatal blood of 7-day-old neonates born to pre-eclamptic and normotensive healthy mothers. MethodsThe study was performed on 30 neonates born to pre-eclamptic and 20 neonates born to normotensive mothers. IMA and OxLDL were determined on spectrophotometry and ELISA, respectively. ResultsIMA in cord blood was higher in the pre-eclamptic group as compared with the normotensive group, but the difference between the groups was not significant. IMA in neonate venous blood was significantly higher in the pre-eclamptic group than in the normotensive group (P < 0.001). OxLDL in both cord blood and in neonate venous blood was significantly higher in the pre-eclamptic group compared with the normotensive group (P < 0.001). IMA and OxLDL were significantly decreased after delivery in both groups. ConclusionsSignificantly increased cord blood OxLDL and significantly increased OxLDL and IMA 7days after birth in neonates born to pre-eclamptic mothers might be an indicator of increased oxidative stress in pre-eclampsia.
  • Küçük Resim Yok
    Öğe
    Serum ischemia-modified albumin levels at diagnosis and during treatment of late-onset neonatal sepsis
    (TAYLOR & FRANCIS LTD, 2014) Yerlikaya, Fatma Hümeyra; Kurban, Sevil; Mehmetoğlu, İdris; Annagür, Ali; Altunhan, Hüseyin; Erbay, Ekrem; Örs, Rahmi
    Sepsis is one of the most common infectious conditions in the neonatal period, and continues as a major source of morbidity and mortality. The aim of this study is to determine serum ischemia-modified albumin (IMA) levels in late-onset neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow-up. Also, it is aimed to compare serum IMA levels with serum C-reactive protein (CRP), procalcitonin (PCT) levels and white blood cell count. The study was performed on 33 premature babies with sepsis and 21 healthy premature controls at 7-28 days of age. In the sepsis group, biochemical parameters and blood culture samples were obtained from the blood at the onset and on the fifth day of treatment for each patient. Serum IMA, CRP, PCT and white blood cell count were significantly higher in the sepsis group before treatment when compared with the control group. In addition, the levels of IMA were positively correlated with white blood cell count, CRP and PCT in the sepsis group before treatment. In conclusion, serum IMA levels may be useful in late-onset neonatal sepsis at the time of diagnosis and after therapy. As far as we know this is the first report about the assesment of illness diagnosis and after therapy using serum IMA levels, and further studies are needed to confirm our results in larger groups of patients.