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  • Küçük Resim Yok
    Öğe
    8-Isoprostane and Coenzyme Q10 Levels in Patients with Metabolic Syndrome
    (MARY ANN LIEBERT, INC, 2016) Ercan, Humeyra; Kiyici, Aysel; Marakoglu, Kamile; Oncel, Mufide
    Background: Metabolic syndrome has become an important health problem, which involves obesity, hyper-lipidemia, insulin resistance, and high blood pressure values. The components of metabolic syndrome are all suggested as independent cardiovascular disease risk factors along with high mortality and morbidity rates accompanied by many organ and system complications. Objective: We aimed to determine 8-isoprostane (8-IsoP) and coenzyme Q10 (CoQ10) levels in patients with metabolic syndrome and healthy individuals and demonstrate whether there was any relation between these parameters and metabolic syndrome criteria. Materials and Methods: A total of 30 patients (10 male, 20 female) with metabolic syndrome and 20 age-matched healthy individuals (9 male, 11 female) were involved in the study. Body mass index, waist and hip circumferences, systolic and diastolic blood pressures and serum glucose, triglyceride, total cholesterol, high-density lipoprotein cholesterol, insulin, HbA1c, 8-IsoP and CoQ10 levels, and homeostasis model assessment of insulin resistance indexes of all participants were determined. Results: 8-IsoP levels were significantly increased in metabolic syndrome compared to healthy individuals (P = 0.003), however, there was no significant difference between groups for CoQ10 levels. 8-IsoP levels were positively correlated with waist circumference (r = 0.303, P=0.032), diastolic blood pressure (r = 0.337, P = 0.017), systolic blood pressure (r = 0.329, P = 0.020) values and total cholesterol levels (r = 0.354, P=0.012). Conclusion: We can suggest that the levels of 8-IsoP, which is an indicator of the oxidative stress, increase in metabolic syndrome and this can be associated with high blood pressure and visceral adiposity, which are the components of metabolic syndrome.
  • Küçük Resim
    Öğe
    Metabolik sendromlu hastalarda ve sağlıklı bireylerde oksidatif stresin araştırılması
    (Selçuk Üniversitesi Sağık Bilimleri Enstitüsü, 2009) Ercan, Humeyra; Kıyıcı, Aysel
    Metabolik sendromda ve sağlıklı bireylerde 8-izoprostan ve koenzimQ10 düzeylerini saptayıp; bu parametrelerin birbirleri ile ve metabolik sendrom tanı kriterleri ile ilişkileri olup olmadığını ortaya koymayı amaçladığımız çalışmamız 30 metabolik sendrom hastası ile 20 sağlıklı kontrol üzerinde gerçekleştirilmiştir. Hasta ve kontrol gruplarının VKİ, bel çevresi, kalça çevresi, sistolik ve diastolik kan basıncı ölçümleri ile serum glukoz, lipid, insülin, HbA1c, 8-izoprostan ve koenzimQ10 düzeyleri, HOMA-IR indeksleri belirlenmiştir. Metabolik sendromda 8-izoprostan düzeyleri sağlıklı bireylerden anlamlı olarak yüksek bulunmuştur, ancak koenzimQ10 düzeyleri açısından gruplar arasında anlamlı bir fark bulunamamıştır. 8-izoprostan düzeyleri hem hipertansiyon hem de viseral yağlanma ile ilişkili gibi görünmektedir. Metabolik sendromdaki artmış oksidatif stresin mekanizmasını aydınlatmaya yönelik ileri çalışmalara ihtiyaç vardır.