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  • Küçük Resim
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    2,3-furandion'ların çeşitli nükleofillerle bazı yeni reaksiyonlarının araştırılması
    (Selçuk Üniversitesi Fen Bilimleri Enstitüsü, 2011-01-12) Erdem, Ahmet; Şen, Nejdet
    Bu çalışmada sırasıyla N- nükleofiller ve çeşitli karbonillerle yeni bisiklik oksalil bileşiği olan 4-benzoil-5 fenil-2,3-furandionun nükleofilik ve siklokatılma reaksiyonları araştırıldı. Sonuç olarak sırasıyla 4-Benzoil-1-(2-florfenil)-5-fenil-1H-pirazol-3-karboksilikasit (AE-1), 4-Benzoil-1-(4-florfenil)-5-fenil-1H-pirazol-3-karboksilikasit (AE-2), 4-Benzoil-1-(2-florfenil)-5-fenil-1H-pirazol-3-karbonil klorür (AE-3), 4-Benzoil-1-(2-florfenil)-5-fenil-1H-pirazol-3-karboksiamid (AE-4), 4-Benzoil-1-(2-florfenil)-5-fenil-1H-pirazol-3-karboksilik metil esteri (AE-5), 4-Benzoil-1-(2-florfenil)-5-fenil-1H-pirazol-3-karboksilik propil esteri (AE-6), 2-(2-Florfenil)-6-(2-nitrofenil)-3,4-difenil-2H-pirazol[3,4-d]piridazin-7(6H)-on (AE-7), 2-(2-Florfenil)-6-(3-nitrofenil)-3,4-difenil-2H-pirazol[3,4-d]piridazin-7(6H)-on (AE-8), Benzaldehit-2-florfenil hidrazonu (AE-9) heterosiklik bileşiklerinin izolesi gerçekleştirildi. Bu bileşiklerin yapıları IR, 13C-NMR, 19F-NMR ve 1H-NMR spektrumları ile aydınlatıldı.
  • Küçük Resim Yok
    Öğe
    Effect of luteal phase support after ovulation induction and intrauterine insemination
    (TAYLOR & FRANCIS LTD, 2014) Öktem, Mesut; Altınkaya, S. Özlem; Yımaz, Setenay Arzu; Bozkurt, Nuray; Erdem, Mehmet; Erdem, Ahmet; Gümüşlü, Seyhan
    Objective: This study aimed to evaluate the effect of luteal phase support on clinical pregnancy and live birth rates after ovulation induction and intrauterine insemination (IUI). Methods: 579 cycles from 2010 to 2013 were retrospectively evaluated. Ovarian stimulation was performed with gonadotropins, and rHCG was used for ovulation triggering. All patients received IUI. 451 cycles were supported by receiving vaginal micronized progesterone capsules (142 cycles) or vaginal progesterone gel (309 cycles) whereas 128 cycles were not supported. Results: Clinical pregnancy (20.6 versus 9.4%; p = 0.004) and live birth rates (14 versus 7%; p = 0.036) were higher for supported group than for unsupported group. Progesterone gel and micronized progesterone subgroups achieved similar clinical pregnancy and live birth rates (21.4 versus 19%, p = 0.567 and 14.2 versus 13.4%, p = 0.807; respectively). Conclusions: Luteal phase support improved the success of IUI cycles affecting both clinical pregnancy and live birth rates when gonadotropins were used for ovulation induction. The use of vaginal progesterone gel or micronized progesterone significantly improves clinical pregnancy rates. The live birth rates were higher in the progesterone gel group, but were similar in the micronized progesterone group compared to the unsupported group.
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    The Synthesis and Reactions of Novel Pyrazole Derivatives by 4-phenylcarbonyl-5-phenyl-2,3-dihydro-2,3-furandione Reacted with Some Hydrazones
    (CHIMINFORM DATA S A, 2017) Erdem, Ahmet; Genc, Hasan; Sen, Nejdet; Kilincarslan, Rafet; Erdem, Emin
    We report some novel pyrazole derivatives taking 4-phenylcarbonyl-5-phenyl-2,3-dihydro-2,3-furandione, I. For this, 4-phenylcarbonyl-5-phenyl-2,3-dihydro-2,3-furandione, 1 was reacted with benzaldehyde (2- or 4-fluorophenyl)hydrazone to give 4-benzoyl-1-(2- or 4-fluorophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid 2a,b. Pyrazol derivative containing 2-fluorophenyl group 2a was converted into carboxylic chloride derivative 3a by thionyl chloride and then the compound 4a was obtained from reaction ammonia with compound 3a. In the next step, 4-benzoyl-1-(2-fluorophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid 2a was reacted with MeOH/H2SO4, EtOH/H2SO4, 2-nitrophenylhydrazine and 3-nitrophenylydrazine to give 5a,b and 6a,b pyrazol derivatives, respectively. The structures regarding all compounds synthesized were determined by the IR, NMR and elemental analysis method.