Yazar "Erdem, Said Sami" seçeneğine göre listele

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    Association between ischemia-modified albumin, homocysteine, vitamin B-12 and folic acid in patients with severe sepsis
    (WALTER DE GRUYTER GMBH, 2012) Erdem, Said Sami; Yerlikaya, Fatma Humeyra; Cicekler, Humeyra; Gul, Mehmet
    Background: The aim of the present study was to investigate scrum ischemia-modified albumin (IMA), homocysteine, malondialdehyde (MDA), vitamin B-12 and folic acid levels in patients with severe sepsis, compared to healthy control subjects. Also, we examined associations of these parameters with high-sensitivity C-reactive protein (hsCRP) in patients with severe sepsis and healthy control subjects. Methods: This study was performed on 71 (40 male, 31 female) patients with severe sepsis aged 18-65 years and 70 (34 male, 36 female) healthy control subjects aged 18-65 years. Samples of patients were obtained at study entry within 24 h of onset of severe sepsis. Results: Serum IMA, homocysteine and MDA levels of the patients with severe sepsis were significantly higher than those of the healthy control subjects (p<0.0 I for IMA and homocysteine, and p<0.001 for MDA). There was no significant difference between serum vitamin B12 and folic acid levels of the groups. Serum hsCRP levels were positively correlated with IMA (p<0.01) and MDA (p<0.01) in the patients with severe sepsis. Conclusions: Our findings show that IMA may be useful as a prognostic biomarker because it can indicate the severity of illness in patients with sepsis.
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    EFFECTS OF PHOTOTHERAPY ON SERUM PARAOXONASE ACTIVITY AND TOTAL ANTIOXIDANT CAPACITY IN NEWBORN JAUNDICE
    (NOBEL ILAC, 2014) Kurban, Sevil; Annagür, Ali; Altunhan, Hüseyin; Mehmetoğlu, İdris; Örs, Rahmi; Erdem, Said Sami; Yerlikaya, Fatma Hümeyra
    Objective: Phototherapy is an efficient and commonly used form of therapy for the treatment of neonatal hyperbilirubinemia. Paraoxonase 1 (PON1) is an anti oxidative enzyme, which eliminates lipid peroxides. The aim of our study was to investigate the effect of phototherapy on serum PON1 activity and total antioxidant capacity (TAC) in hyperbilirubinemic full-term newborns. Material and Method: The study was performed on 40 full-tenn newborns between 3 to 15 days of age exposed to phototherapy. SerumPON1 activity and TAC levels of the babies were determined before and after phototherapy by spectrophotometric assays. Results: We have found that PON1 activity was not significantly affected by phototherapy whereas TAC levels were decreased significantly after phototherapy (p<0.001). Conclusion: Our findings demonstrated that phototherapy has no direct effect on PON1 activity. Also, decreased TAC levels might have resulted from increased oxidative stress which may lead to consumption of antioxidant molecules.
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    Effects of phototherapy on serum paraoxonase activity and total antioxidant capacity in newborn jaundice
    (Nobelmedicus, 2014) Kurban, Sevil; Annagür, Ali; Altunhan, Hüseyin; Mehmetoğlu, İdris; Örs, Rahmi; Erdem, Said Sami; Yerlikaya, Fatma Hümeyra
    Objective: Phototherapy is an efficient and commonly used form of therapy for the treatment of neonatal hyperbilirubinemia. Paraoxonase 1 (PON1) is an antioxidative enzyme, which eliminates lipid peroxides. The aim of our study was to investigate the effect of phototherapy on serum PON1 activity and total antioxidant capacity (TAC) in hyperbilirubinemic full-term newborns.Material and Method: The study was performed on 40 full-term newborns between 3 to 15 days of age exposed to phototherapy.Serum PON1 activity and TAC levels of the babies were determinedbefore and after phototherapy by spectrophotometric assays.Results: We have found that PON1 activity was not significantly affected by phototherapy whereas TAC levels were decreased significantly after phototherapy (p<0.001).Conclusion: Our findings demonstrated that phototherapy has no direct effect on PON1 activity. Also, decreased TAC levels might have resulted from increased oxidative stress which may lead to consumption of antioxidant molecules. © 2014, Nobelmedicus. All rights reserved.
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    Ischaemia-modified albumin levels in newborn jaundice before and after phototherapy
    (WILEY, 2011) Erdem, Said Sami; Kurban, Sevil; Altunhan, Hüseyin; Annagür, Ali; Örs, Rahmi; Yerlikaya, Fatma Hümeyra; Gökçe, Reşat
    The aim of our study was to assess the effect of phototherapy (PT) on ischaemia-modified albumin (IMA) and malondialdehyde (MDA) levels in hyperbilirubinemic full-term newborns. The study was performed on 36 full-term infants exposed to PT. The babies were aged 3 to 13 days. IMA and MDA levels of the babies were determined before and after PT, by a colorimetric assay. IMA levels before and after PT were found as 0.424 +/- 0.290 and 0.531 +/- 0.262 absorbance units, respectively. Although IMA levels after PT were slightly higher, the difference was not statistically significant (p > 0.131). MDA levels before and after PT were found as 8.4 +/- 1.8 mu mol/l and 9.4 +/- 1.5 mu mol/l, respectively. Serum MDA concentrations were significantly higher after PT than before PT (p < 0.000). In previous studies, conflicting findings have been reported about the effect of PT on oxidant and antioxidant systems. However, we have found no study investigating IMA levels in hyperbilirubinaemia in newborns before and after PT. Our results shows that PT does not affect IMA levels significantly. IMA increases as a result of oxidative stress. We believe that the lack of significant difference between our IMA levels before and after PT may resulted from hyperbilirubinaemia, which has antioxidant effect. Copyright (C) 2011 John Wiley & Sons, Ltd.
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    Kronik obstrüktif akciğer hastalarında serum asimetrik dimetilarjinin (adma) ve nitrik oksit düzeyleri
    (Selçuk Üniversitesi Tıp Fakültesi, 2006) Erdem, Said Sami; Ünlü, Ali
    KOAH ilerleyici hava yolu obstrüksiyonu ve nötrofilik inflamasyonla karakterize, tüm dünyada önemli bir mortalite ve morbidite nedenidir. Pulmoner arteryal hipertansiyon (PAH) sağ kalp yetmezliğine neden olarak ölüme neden olabilen şiddetli bir hastalıktır. PAH küçük pulmoner arterlerde endotelyal hücre proliferasyonu, medial hipertrofi ve adventisyal kalınlaşmayla karakterizedir. PAH'ta endotelyal vasküler disfonksiyonun mekanizması multifaktöryeldir ve nitrik oksit sistemindeki değişiklikleri de kapsar. NO endotelde NOS tarafından arjinin aminoasidinden sentezlenir. ADMA NOS'un endojen inhibitörüdür. Biz çalışmamızda stabil KOAH, akut atak KOAH ve kor pulmonale hastalarında serum ADMA, NO ve arjinin düzeylerini ve kor pulmonale gelişiminde ADMA düzeylerinin rolü olup olmadığını belirlemeyi amaçladık. Çalışmamıza 75 KOAH (n=25 akut atak, n=25 stabil KOAH, n=25 kor pulmonale) hastası dahil edildi. Seçilen hastaların başka herhangi bir hastalığı yoktu. Kontrol grubu 25 görünürde sağlıklı kişiden oluşturuldu. ADMA ve arjinin düzeyleri HPLC metoduyla floresans dedektörde ölçüldü. Plasma Nitrit/Nitrat konsantrasyonları kolorimetrik metodla ölçüldü. SPSS 13,0 for Windows programı yardımıyla istatistiksel analizler yapıldı. Veriler ortalama ± standart sapma ve yüzde olarak özetlendi. Parametrelerin gruplar arası karşılaştırılmasında tek yönlü varyans analizi yapıldı. Varyans analizinin anlamlı çıkması halinde gruplar arası karşılaştırma için Tamhane testinden yararlanıldı. Çalışmamız için p< 0.05 anlamlı kabul edildi. KOAH hastalarında ADMA seviyeleri kontrol grubuna kıyasla yüksek olarak bulundu. Arjinin ve NO seviyeleri açısından iki grup arasında farklılık yokken, KOAH grubunda Arjinin/ADMA oranları kontrol grubundan önemli ölçüde farklıydı. Stabil ve atak gruplarında ADMA değerleri açısından farklılık gözlenmedi. Kor pulmonale grubunda ADMA seviyeleri stabil gruba göre yüksek olarak saptandı. Kor pulmonale ve atak gruplarında ADMA değerleri açısından farklılık gözlenmedi. Kor pulmonale grubunda kontrol ve atak KOAH gruplarına göre düşük arjinin değerleri tespit edildi. Stabil ve kor pulmonale grupları arasında arjinin değerleri açısından farklılık yoktu. NO değerleri açısından gruplar arasında farklılık tespit edilmedi. Arjinin/ADMA oranları atak KOAH ve kor pulmonale grubunda kontrol grubuna göre önemli ölçüde düşüktü. Stabil ve atak KOAH grupları arasında Arjinin/ADMA oranları açısından farklılık gözlenmedi. Sonuç olarak; bizim çalışmamız ADMA seviyelerinin KOAH hastalarında arttığını göstermiştir. KOAH'ın prognozunu belirlemede ADMA yeni bir belirteç olarak kullanılabilir. 51 ADMA KOAH hastalarında meydana gelen pulmoner hipertansiyonun patogenezinde önemli bir rol oynayabilir. Bu yüzden pulmoner hipertansiyonun önlenmesi ve tedavisinde ADMA önemli bir hedef olabilir.
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    Levels of Plasma NPY, Leptin and Nesfatin-1, and Their Relation to Zinc in Children with Obese and Metabolic Syndrome
    (KARGER, 2018) Aydogdu, Adnan; Baltaci, Abdulkerim Kasim; Menevse, Esma; Baltaci, Saltuk Bugra; Mogulkoc, Rasim; Erdem, Said Sami; Buyukinan, Muammer
    [Abstract not Available]
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    The value of serum asymmetric dimethylarginine levels for the determination of masked hypertension in patients with diabetes mellitus
    (ELSEVIER IRELAND LTD, 2013) Taner, Alpaslan; Unlu, Ali; Kayrak, Mehmet; Tekinalp, Mehmet; Ayhan, Selim S.; Aribas, Alpay; Erdem, Said Sami
    Background: An increased prevalence of masked hypertension (MHT) has been demonstrated among patients with diabetes mellitus (DM). MHT appears to cause cardiovascular (CV) complications similar to clinically overt hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and higher plasma levels of ADMA are related to increased CV risk in both the general population and among patients with DM. The aim of this study was to evaluate the relationship between MHT and ADMA in diabetic patients. Methods: This study included DM patients (n = 131) with normal office blood pressure (<140/90 mmHg). None of the participants were using antihypertensive medications. All participants utilized an ambulatory blood pressure monitor (ABPM) for 24 h. Serum ADMA and arginine levels were measured using the fluorescence detector high performance liquid chromatography method. Results: The prevalence of MHT was 24.4% among the study subjects. ADMA levels were increased in the MHT group when compared with normotensive diabetics (6.2 +/- 2.2 vs 4.2 +/- 1.7 mu mol/L p = 0.001, respectively). Furthermore, arginine/ADMA ratio was lower in the MHT group than among the normotensive group (29.9 +/- 12.1 vs 46.0 +/- 19.0 p = 0.001). In the multivariate logistic regression model, ADMA, BMI and HDL levels were found to be independent predictors of MHT Odds ratio: 1.63 (1.28-2.06), 1.19 (1.05-1.35), and 0.95 (0.90-0.99), respectively. The cut-off value of the ADMA was 4.34 mu mol/L with a sensitivity, specificity, positive predictive value, and negative predictive value of 84.4%, 59.6%, of 40.3%, and 92.2%, respectively (AUC - 0.78). Conclusions: Serum ADMA may play a role in both the pathophysiology and screening of MHT in DM subjects. (C) 2013 Elsevier Ireland Ltd. All rights reserved.