Effects of phototherapy on serum paraoxonase activity and total antioxidant capacity in newborn jaundice
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nobelmedicus
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Phototherapy is an efficient and commonly used form of therapy for the treatment of neonatal hyperbilirubinemia. Paraoxonase 1 (PON1) is an antioxidative enzyme, which eliminates lipid peroxides. The aim of our study was to investigate the effect of phototherapy on serum PON1 activity and total antioxidant capacity (TAC) in hyperbilirubinemic full-term newborns.Material and Method: The study was performed on 40 full-term newborns between 3 to 15 days of age exposed to phototherapy.Serum PON1 activity and TAC levels of the babies were determinedbefore and after phototherapy by spectrophotometric assays.Results: We have found that PON1 activity was not significantly affected by phototherapy whereas TAC levels were decreased significantly after phototherapy (p<0.001).Conclusion: Our findings demonstrated that phototherapy has no direct effect on PON1 activity. Also, decreased TAC levels might have resulted from increased oxidative stress which may lead to consumption of antioxidant molecules. © 2014, Nobelmedicus. All rights reserved.
Açıklama
Anahtar Kelimeler
Neonatal hyperbilirubinemia, Paraoxonase, Phototherapy, Total antioxidant capacity
Kaynak
Nobel Medicus
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
10
Sayı
3
