Yazar "Eryilmaz, M. A." seçeneğine göre listele

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    Breast conserving surgery in patients with multifocal/multicentric breast cancer
    (ZERBINIS MEDICAL PUBL, 2011) Eryilmaz, M. A.; Muslumanoglu, M.; Ozmen, V.; Igci, A.; Koc, M.
    Purpose: To retrospectively evaluate the outcome of patients with multifocal (MF) and multicentric (MC) breast cancer treated with conservative surgery Methods: We evaluated 59 patients who had undergone breast conserving surgery (BCS) for MF/MC cancer between 1998-2008. We used sentinel lymph node (SLN) biopsy for all 59 patients and we performed axillary lymph node dissection in those with positive SLN. Local control, overall survival (OS), disease-free survival (DFS) and identification of predictive factors for recurrence were evaluated. Results: Twenty patients with modified radical mastectomy because of persistent positive margins were excluded from the study. Evaluated were 55 patients with MF (93.2%) and 4 (6.8%) with MC disease. Thirty-four patients (57.6%) had 2, 20 patients (33.9%) had 3 and 5(8.5%) had 4 or more tumor foci. Median follow up time was 20 months (range 297). The projected 5- and 8-year OS were 95% and 89% respectively, and DFS 92.3%. At multivariate analysis, overexpression of human epidermal growth factor receptor 2 (HER-2) was associated with a higher ipsilateral breast cancer recurrence. Menopausal status, MF/MC disease, number of tumor foci (2 vs. >= 3), histological grade, extracapsular extension (ECE), lymphovascular invasion (LVI), and hormone receptor status were not associated with ipsilateral breast cancer recurrence. Conclusion: Our study demonstrates that in selected patients with MF/MC breast cancer, wide conservative surgery is a safe therapy.
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    The Effects of Smoking Cessation on Visceral Adiposity Index Levels
    (WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2018) Pekgor, S.; Duran, C.; Marakoglu, K.; Solak, I.; Pekgor, A.; Eryilmaz, M. A.
    Background: Known to cause important metabolic disturbances, weight gain becomes a major health problem after smoking cessation. Visceral adiposity index (VAI) is becoming increasingly popular in the detection of cardiometabolic risks in several disorders and general population. Here, we aimed to investigate the effects of quitting smoking on VAI levels. Materials and Methods: Of 350 participants included into the cigarette cessation program, 70 (20%) completed the study and were enrolled into the analyses. VAI levels were calculated at the baseline and 3rd month after cigarette cessation. Results: Thirty-eight (54.3%) out of 70 participants were male. While the mean age was found as 42 +/- 1.0 years, mean starting age of smoking was found to be 16.87 +/- 0.45 years, and mean smoking time was 23.07 +/- 1.18 years. While VAI levels were found higher in men at the baseline, VAI levels were found similar in both genders at the end of the study. Higher VAI levels were found in those smoking > 20 cigarettes/ day, compared to those smoking = 20 cigarettes/ day. Although weight, waist circumference, body mass index (BMI), and high-density lipoprotein cholesterol levels increased, VAI levels were found to decrease significantly at the 3rd month. In subgroup analyses, VAI levels were seen to decrease significantly only in men (P = 0.005). Furthermore, VAI levels were found to decrease (P < 0.001) in those with BMI = 25 kg/ m2, whereas no significant change was observed in those with BMI < 25 kg/ m2. Conclusions: Although body weight increases significantly after quitting smoking, VAI levels, an indicator of cardiovascular risks, decrease significantly, especially in men or obese patients.