Breast conserving surgery in patients with multifocal/multicentric breast cancer
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ZERBINIS MEDICAL PUBL
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To retrospectively evaluate the outcome of patients with multifocal (MF) and multicentric (MC) breast cancer treated with conservative surgery Methods: We evaluated 59 patients who had undergone breast conserving surgery (BCS) for MF/MC cancer between 1998-2008. We used sentinel lymph node (SLN) biopsy for all 59 patients and we performed axillary lymph node dissection in those with positive SLN. Local control, overall survival (OS), disease-free survival (DFS) and identification of predictive factors for recurrence were evaluated. Results: Twenty patients with modified radical mastectomy because of persistent positive margins were excluded from the study. Evaluated were 55 patients with MF (93.2%) and 4 (6.8%) with MC disease. Thirty-four patients (57.6%) had 2, 20 patients (33.9%) had 3 and 5(8.5%) had 4 or more tumor foci. Median follow up time was 20 months (range 297). The projected 5- and 8-year OS were 95% and 89% respectively, and DFS 92.3%. At multivariate analysis, overexpression of human epidermal growth factor receptor 2 (HER-2) was associated with a higher ipsilateral breast cancer recurrence. Menopausal status, MF/MC disease, number of tumor foci (2 vs. >= 3), histological grade, extracapsular extension (ECE), lymphovascular invasion (LVI), and hormone receptor status were not associated with ipsilateral breast cancer recurrence. Conclusion: Our study demonstrates that in selected patients with MF/MC breast cancer, wide conservative surgery is a safe therapy.
Açıklama
Anahtar Kelimeler
breast cancer, conservative surgery, multicentric, multifocal
Kaynak
JOURNAL OF BUON
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
16
Sayı
3
