Breast conserving surgery in patients with multifocal/multicentric breast cancer

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dc.contributor.authorEryilmaz, M. A.
dc.contributor.authorMuslumanoglu, M.
dc.contributor.authorOzmen, V.
dc.contributor.authorIgci, A.
dc.contributor.authorKoc, M.
dc.date.accessioned2020-03-26T18:13:53Z
dc.date.available2020-03-26T18:13:53Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To retrospectively evaluate the outcome of patients with multifocal (MF) and multicentric (MC) breast cancer treated with conservative surgery Methods: We evaluated 59 patients who had undergone breast conserving surgery (BCS) for MF/MC cancer between 1998-2008. We used sentinel lymph node (SLN) biopsy for all 59 patients and we performed axillary lymph node dissection in those with positive SLN. Local control, overall survival (OS), disease-free survival (DFS) and identification of predictive factors for recurrence were evaluated. Results: Twenty patients with modified radical mastectomy because of persistent positive margins were excluded from the study. Evaluated were 55 patients with MF (93.2%) and 4 (6.8%) with MC disease. Thirty-four patients (57.6%) had 2, 20 patients (33.9%) had 3 and 5(8.5%) had 4 or more tumor foci. Median follow up time was 20 months (range 297). The projected 5- and 8-year OS were 95% and 89% respectively, and DFS 92.3%. At multivariate analysis, overexpression of human epidermal growth factor receptor 2 (HER-2) was associated with a higher ipsilateral breast cancer recurrence. Menopausal status, MF/MC disease, number of tumor foci (2 vs. >= 3), histological grade, extracapsular extension (ECE), lymphovascular invasion (LVI), and hormone receptor status were not associated with ipsilateral breast cancer recurrence. Conclusion: Our study demonstrates that in selected patients with MF/MC breast cancer, wide conservative surgery is a safe therapy.en_US
dc.identifier.endpage453en_US
dc.identifier.issn1107-0625en_US
dc.identifier.issue3en_US
dc.identifier.pmid22006748en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage450en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26208
dc.identifier.volume16en_US
dc.identifier.wosWOS:000295563900010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherZERBINIS MEDICAL PUBLen_US
dc.relation.ispartofJOURNAL OF BUONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbreast canceren_US
dc.subjectconservative surgeryen_US
dc.subjectmulticentricen_US
dc.subjectmultifocalen_US
dc.titleBreast conserving surgery in patients with multifocal/multicentric breast canceren_US
dc.typeArticleen_US

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