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Öğe Colon Agenesis With Ileovesical Fistula and Anorectal Malformation(W B Saunders Co-Elsevier Inc, 2010) Yurtçu, Müslim; Esen, H. Hasan; Günel, EnginColonic agenesis is a rare cause of congenital bowel obstruction and is usually associated with other malformations such as abdominal wall defects or gastrointestinal, cardiac, urogenital, and musculoskeletal lesions. Although many uncommon types have been reported, ileovesical fistula (IVF) associated with total colonic agenesis (TCA) has not been reported in a newborn with anorectal malformation (ARM). This is the first report of a 1-day-old newborn with ARM, IVF, and TCA.Öğe Effects of Phototherapy on the Growth Plate in Newborn Rats(Lippincott Williams & Wilkins, 2006) Atabek, Mehmet Emre; Pirgon, Özgür; Kurtoğlu, Selim; Tavlı, Lema; Esen, H. Hasan; Köylü, Öznur; Erkul, İbrahimThe aim of the present study was to evaluate the effect of phototherapy and oxidative stress on the growth plate of newborn rats. Forty newborn Sprague-Dawley rats were randomized into a phototherapy group and a control group. Twenty of the rats received phototherapy for 7 days. All zones of the growth plate were assessed with quantitative histomorphometric analysis. Individual zonal lengths were measured for the reserve zone (RZ), the proliferative zone (PZ), the hypertropbic zone (HZ), ossifying cartilage (OC), and total zone (TZ) of the growth plate. Levels of plasma malondialdehyde (MDA), an index of oxidative stress, were also evaluated. Compared with zonal lengths on day 7 after phototherapy between the two groups, the phototherapy group had significantly lower values than those of controls for RZ (5.13 +/- 0.36 vs. 6.4 +/- 0.85 mm X 10(-2); P < 0.001), PZ (20.6 +/- 3.0 vs. 29.25 +/- 1.68 mm X 10(-2); p < 0.001), HZ (15.4 +/- 1.44 vs. 20.87 +/- 1.12 mm X 10(-1); P < 0.001), OC (47.08 +/- 4.25 vs. 62.06 +/- 3.7 mm X 10(-2); p < 0.001), and TZ (88.15 +/- 6.56 vs. 118.48 +/- 4.50 mm X 10(-2); p < 0.001). Plasma MDA levels were correlated with the size of the PZ in the phototherapy group (r = -0.53, P = 0.01). In a multivariate regression model for all rats, being in the phototherapy group was the best predictor of the size of the TZ (beta = -0.94, P < 0.001), with the total variance explained being 88%. These results suggest that in newborn rats, receiving phototherapy is associated with early impairment of growth plate structure, and oxidative stress may be the main risk factor for growth plate injury.Öğe Extensive brown tumors caused by parathyroid adenoma in an adolescent patient(SPRINGER, 2008) Atabek, Mehmet Emre; Pirgon, Ozgur; Sert, Ahmet; Esen, H. HasanPrimary hyperparathyroidism is a rare endocrine disease in children and young adults. The early detection and treatment of primary hyperparathyroidism led to a marked decrease in classical bone and renal manifestations of the disease. Osteitis fibrosa cystica and brown tumors have become extremely rare clinical entities. Moreover, the skeletal involvement in primary hyperparathyroidism secondary to parathyroid adenoma is extremely rare. We report on an adolescent girl with multiple brown tumors and a history of recurrent fractures as the manifestation of primary hyperparathyroidism associated with a parathyroid adenoma. The patient's clinical presentation mimicked parathyroid carcinoma. She had a large tumor associated with marked elevation in the parathyroid hormone and serum calcium levels. Skeletal manifestations were also atypical for benign primary hyperparathyroidism, with widespread brown tumors in the patient.Öğe Infantile systemic hyalinosis with early thyroid dysfunction(WALTER DE GRUYTER GMBH, 2007) Pirgon, Ozgur; Atabek, Mehmet Emre; Esen, H. Hasan; Cangul, H.Infantile systemic hyalinosis is an autosomal recessive disorder characterized by diffuse hyaline deposits in the skin, gastrointestinal tract, muscles and glands. The molecular basis of infantile systemic hyalinosis is unknown. The main pathological feature is widespread hyalinosis of many tissues and organs. We present an 18 month-old girl with infantile systemic hyalinosis and hypothyroidism. Newly diagnosed children with infantile systemic hyalinosis should have thyroid studies as a routine part of diagnostic work-up.Öğe Prostat adenokarsinomlarında psa değerlerinin gleason skor ve klinik evre ile ilişkisi(Selçuk Üniversitesi Tıp Fakültesi, 2005) Esen, H. Hasan; Avunduk, Mustafa CihatAmaç : Prostat Adenokarsinomlarında PSA değerlerinin, Gleason Skor ve Klinik Evre ile ilişkisi. Materyal Metod : Çalışmamızda 68 PACa olgusu ile 55 BPH olgusu incelendi. H&E ile boyanan preparatlar ışık mikroskobunda incelendi. Histolojik Grade olarak Gleason Grade sistemi kullanıldı. Olgular WHO ve TNM sınıflamasına göre evrelendirildi. Olguların total ve s-PSA değerleri Beckman Coulture DXI800 marka cihazları kullanılarak `chemiluminescence' metodu ile ölçüldü. Veriler bilgisayar ortamına aktarılarak `SPPS for Window's 10.0' programı ile istatistiksel analiz yapıldı. Veriler ortalama ± standart sapma şekline özetlendi. Gruplar arası karşılaştırma için Stedent-t testi kullanıldı. Parametreler arası ilişki Spearman's korelasyon testi ile değerlendirildi. Cut-off noktası tespiti için ROC analizi yapıldı ve anlamlılık değeri olarak 0.05 seviyesi alındı. Bulgular : Çalışmamızda PACa ile BPH olguları arasında ortalama yaşlarda fark tespit edimedi. Ortalama serum t-PSA değerleri: PACa olguları 67.09±5.32 ng/ml iken BPH da 4.70±1.02 ng/ml olarak bulundu. PACa olgularının 56 sında t-PSA â ¥10 ng/ml iken, BPH lı olguların 51 inde t-PSA <10 ng/ml olarak tespit edildi. Gri Zon aralığında 11 PACa, 24 BPH olgusu bulunmaktadır. Bu olgularda t-PSA , s-PSA ve yaş arasında bir fark tespit edilemeyip, s-PSA/ t-PSA oranı anlamlı derecede farklı bulunmuştur. 0.18 sınır değeri için spesifite %92, sensivite %82, 0.16 değeri için spesifite % 95 sensivite %55 dir. 48 PACa olgusuna klinik evreleme yapılabildi, bunlardan da 5 olgu Evre A, 12 olgu Evre B, 14 olgu Evre C, 17 olgu ise Evre D olarak bulundu. 48 olgudan 4 tanesi: GS 2-4, 15 tanesi; GS 5-6, 19 tanesi; GS 7, 10 tanesi GS 8-10. GS 2-6 arasında olan 19 olgunun tamamı Evre A, B, C ( lokalize evre), GS 7-10 olan 29 olgunun 12 tanesi Evre B ve C ( lokalize evre ) 17 tanesi Evre D ( metastatik evre ) de idi. Serum t-PSA düzeyi 0-10 ng/ml aralığında olan 9 PACa olgusunun 8 tanesi lokalize evrede 1 tanesi metastatik evrede tespit edilmiştir. Bu PSA aralığında 7 olgunun GS si 7 den düşük iken sadece 2 olgunun GS si 7-10 aralığında tespit edildi. Lokalize evrede olgularında ortalama serum t-PSA seviyesi: 44.8±6.76 ng/ml iken metastatik evrede 120.2 ± 8.65 ng/ml tespit edildi. 91 Sonuç : Serum t-PSA düzeyi parametresinin kullanımı faydalı bir belirteçtir. PSA; PCa tanısında, evrelemesinde, histolojik grade' i tahmin etmede, izlemde ve rekürrenslerin belirlenmesinde iyi bir göstergedir. s-PSA/ t-PSA oranı, t-PSA değeri 4,1-10 ng/ml düzeyinde olan benign ve malign olguları ayırmada son derece yaralı bir parametredir. GS nin kullanılması, PCa lı olgularda progresyonu ve sağ kalımı belirlemede iyi ve güvenilir bir göstergedir.Öğe Protective effect of pentoxifylline on growth plate in neonatal rats following long-term phototherapy(INT PEDIATRIC RESEARCH FOUNDATION, INC, 2007) Atabek, Mehmet Emre; Pirgon, Ozgur; Esen, H. HasanWe demonstrated previously that receiving long-term phototherapy was associated with early impairment of growth plate structure in neonatal rats, and oxidative stress may be the main risk factor for growth plate injury. The purpose of this study was to examine the histomorphometric effects of pentoxifylline treatment on the growth plate. Sixty weanling Sprague-Dawley rats were randomly separated into three equal groups. Group A, the control group, did not receive phototherapy and pentoxifylline. Groups B and C were exposed to phototherapy for 7 d. In addition to phototherapy, group C was also given pentoxifylline during the study period. Compared with zonal lengths on d 7 after initiation of phototherapy, group B had significantly lower values than group A for all zonal lengths (p < 0.001). Zonal lengths of growth plate were increased significantly with pentoxifylline treatment in group C for 7 d compared with group B (p < 0.001). After phototherapy, group B had significantly higher values than groups A and C for plasma malondialdehyde levels (p < 0.001). The pentoxifylline was found here to have some potential to reduce the effects of phototherapy on growth plate in neonatal rats at a relatively low dose.Öğe Survivin and cycline D1 expressions are associated with malignant potential in mucinous ovarian neoplasms(SPRINGER, 2016) Kanter, Mehmet; Turan, Gulay; Usta, Ceyda; Usta, Akin; Esen, H. Hasan; Tavli, Lema; Celik, CetinThe most prevalent malignant ovarian neoplasms are epithelial ovarian cancers which is the most common cause of death among all gynecologic malignancies and a result of complex interaction of multiple oncogenes and tumor suppressor genes. The aim of this study was to evaluate expression of survivin and cycline D1 biomarkers in mucinous ovarian neoplasms and their correlations with clinicopathological variables in mucinous ovarian cancers. We analyzed pathological specimens of 98 patients with benign (n = 34), borderline (n = 22) and malignant (n = 42) mucinous ovarian neoplasms. Immunohistochemical analysis was performed on formalin-fixed paraffin-embedded specimens. Immunohistochemical analysis revealed that survivin and cyclin D1 expressions were located primarily in the nucleus of ovarian tumor cells and relatively weaker cytoplasmic staining. Survivin expression was significantly higher in malignant tumors (88.1 %) than those found in borderline (18.2 %) and benign tumors (8.8 %) (p < 0.001). Similarly, higher cyclin D1 expression was observed in malignant tumors (100 %) compared to borderline (36.4 %) and benign tumors (5.9 %) (p < 0.001). Expression of all biomarkers analyzed significantly and gradually increased from benign to borderline and borderline to malignant mucinous tumors. In terms of clinicopathological variables, tumor grade, FIGO stage and lymph node methastasis were associated with the expression of both biomarkers. Whereas age exhibited no different correlations in mucinous ovarian cancers. The expressions of survivin and cycline D1 are positively correlated with the malignant potential of mucinous ovarian neoplasms.
