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    A Comparison of the Effects of Adcon-L, Mitomycin C and Sodium Hyaluronate in Experimental Epidural Fibrosis in Rabbits
    (JOURNAL NEUROLOGICAL SCIENCES, 2011) Kaya, Bulent; Esen, Haci Hasan; Ustun, Mehmet Erkan
    Objective: Epidural fibrosis and leptomeningeal adhesion formation are among the common causes of failed back surgery syndrome. Various materials have been used to prevent the compressive effect of postoperative epidural fibrosis on neural structures. The effects of Adcon L, Mitomycin C and sodium hyaluronate on epidural fibrosis compared in this experimental study. Methods: 28 rabbits divided into 4 different groups. L5 total laminectomy performed under ketamine and xyzlazine anasthesia. Group1 settled as control group and had no medications after laminectomy. Adcon L in group 2, Mitomycin C in group3 and sodium hyaluronate in group 4 were applied to laminectomy area. All groups sacrified 6 weeks after laminectomy. Histologic slices were invastigated under light microscobe according to their histopathological features and the groups were compared. Result: Grade 3 fibrosis determinated in group1. Statistically significant differences between group1 and all other groups were obtained (p < 0.05) No statistically significant differences was determinated between group 2, 3 and 4 respectively. Conclusions: All medications we use decreased postoperative epidural fibrosis in this study. But further studies are needed for routine application of these medications.
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    AN EARLY DIAGNOSTIC TOOL FOR DIABETIC NEUROPATHY: CONDUCTION VELOCITY DISTRIBUTION
    (WILEY, 2011) Tuncer, Seckin; Dalkilic, Nizamettin; Esen, Haci Hasan; Avunduk, Mustafa Cihat
    Diabetes is a metabolic disorder that. affects much of the human population. As a secondary complication, diabetic neuropathy causes time-dependent damage to peripheral nerves. In this study, experimental diabetes was induced by streptozotocin (STZ; 50 mg/kg intraperitoneally) in rats. Diabetic animals were grouped into those with 2 or 4 weeks of diabetes, whereas a control group received only the STZ vehicle (0.1 M citrate). Sciatic nerves were dissected, and compound action potentials (CAPS) were recorded. Results deduced by conventional calculation carried less information when compared with conduction velocity distribution (CVD) obtained by a computer-based mathematical model. Using the conventional approach, statistically significant changes were first seen in the fourth week of diabetes, whereas results deduced by CVD measurement could be seen in the second week. Consequently, the CVD calculation provides more information for the early diagnosis of neuropathies compared with classical conduction velocity measurements. Muscle Nerve 43: 237-244, 2011