A Comparison of the Effects of Adcon-L, Mitomycin C and Sodium Hyaluronate in Experimental Epidural Fibrosis in Rabbits
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
JOURNAL NEUROLOGICAL SCIENCES
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Epidural fibrosis and leptomeningeal adhesion formation are among the common causes of failed back surgery syndrome. Various materials have been used to prevent the compressive effect of postoperative epidural fibrosis on neural structures. The effects of Adcon L, Mitomycin C and sodium hyaluronate on epidural fibrosis compared in this experimental study. Methods: 28 rabbits divided into 4 different groups. L5 total laminectomy performed under ketamine and xyzlazine anasthesia. Group1 settled as control group and had no medications after laminectomy. Adcon L in group 2, Mitomycin C in group3 and sodium hyaluronate in group 4 were applied to laminectomy area. All groups sacrified 6 weeks after laminectomy. Histologic slices were invastigated under light microscobe according to their histopathological features and the groups were compared. Result: Grade 3 fibrosis determinated in group1. Statistically significant differences between group1 and all other groups were obtained (p < 0.05) No statistically significant differences was determinated between group 2, 3 and 4 respectively. Conclusions: All medications we use decreased postoperative epidural fibrosis in this study. But further studies are needed for routine application of these medications.
Açıklama
Anahtar Kelimeler
Epidural fibrosis, Adcon L, Mitomycin C, sodium hyaluronate, Failed back surgery syndrome
Kaynak
JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
28
Sayı
2
