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Öğe A comparison of the effects of Adcon-L Mitomycin C and sodium hyaluronate in experimental epidural fibrosis in rabbits [Tavşanlarda Oluşturulan Deneysel Epidural Fibroziste Adcon-L, Mitomisin-C ve Sodyum Hyaluronat'ın Etkilerinin Karşılaştırılması](Ege University Press, 2011) Kaya B.; Esen H.H.; Üstün M.E.Objective: Epidural fibrosis and leptomeningeal adhesion formation are among the common causes of failed back surgery syndrome. Various materials have been used to prevent the compressive effect of postoperative epidural fibrosis on neural structures. The effects of Adcon L, Mitomycin C and sodium hyaluronate on epidural fibrosis compared in this experimental study. Methods: 28 rabbits divided into 4 different groups. L5 total laminectomy performed under ketamine and xyzlazine anasthesia. Group1 settled as control group and had no medications after laminectomy. Adcon L in group 2, Mitomycin C in group3 and sodium hyaluronate in group 4 were applied to laminectomy area. All groups sacrified 6 weeks after laminectomy. Histologic slices were invastigated under light microscobe according to their histopathological features and the groups were compared. Result: Grade 3 fibrosis determinated in group1. Statistically significant differences between group1 and all other groups were obtained (p<0.05) No statistically significant differences was determinated between group 2, 3 and 4 respectively. Conclusions: All medications we use decreased postoperative epidural fibrosis in this study. But further studies are needed for routine application of these medications.Öğe The effects of medical ozone in rat heart exposed to ischemia-reperfusion injury: Experimental study(2012) Tanyeli Ö.; Yüksek T.; Görmüş N.; Ulu N.; Kiyici A.; Esen H.H.Objective: In this study, it was intended to investigate the effects of preconditioning with medical ozone on possible reperfusion injury, in which patients undergoing the operation due to coronary artery disease. Material and Methods: 37 female mature rats were categorized into 4 groups either as sham-control (Group I), ischemia (Group II), ischemic preconditioning by oxygen (Group III) or by medical ozone (Group IV). Through left thoracotomy, rats were subjected to 25 min of ischemia on left anterior descending (LAD) coronary artery and after that, reperfusion was provided for 75 min. At the end of this period, serum sampling for creatinine-kinase (CK)-MB, Troponin-I, superoxide dismutase (SOD) and malondialdehyde (MDA) and tissue sampling for histopathological examinations were performed. The results of pathological examination were divided into 3 groups according to cellular damage. Results: Statistically, there were no significant differences between the groups in case of CK-MB levels and SOD enzymatic activity (p>0.05). Nevertheless, Troponin-I was higher in Group III and MDA was meaningfully lower in Group IV in respect to control group (p=0.005). Moreover, MDA levels were significantly lower in Group IV, when compared to Group III. With these results, no significant differences were detected between ischemia and ozone group. Although it is important to detect lower MDA levels in ozone group when compared to oxygen group, it is hard to talk about protective effects of ozone just depending on this data. In histopathological examination, medical ozone had beneficial effects on cellular protection when compared to ischemic group; but when the groups were examined, no significant differences could be found between oxygen and ozone groups. Conclusion: Although the role of medical ozone on the prevention of reperfusion injury could not be demonstrated clearly, it might have some beneficial effects after biochemical and histopathological evaluation. To be able to show these effects precisely, more studies are needed. Copyright © 2012 by Türkiye Klinikleri.Öğe Evaluation of TGF beta 1 expression and comparison the thickness of different aorta layers in experimental diabetes(2011) Cuce G.; Kalkan S.S.; Esen H.H.Background: It was aimed to investigate the effects of experimental diabetes on TGF ß1 expression and tunica intima and media thickness in abdominal and thoracic aorta. Methods: Fourteen three months old female rats were divided into two groups, non-diabetic and streptozotocin (STZ) induced diabetic group. Hematoxylin-Eosin and Verhoeff's Van Gieson elastic staining and TGF ß1 im-munohistochemistry staining were performed. Abdominal and thoracic intima and media thickness of aortas were measured with the oculometer. Results: Evaluation of intima and media thickness measurements showed no significant statistical differences between non-diabetic and diabetic groups. TGF ß1 expression increased significantly in thoracic diabetic (TD) group. Conclusion: The 60 day duration of diabetes is not sufficiently enough time for the development of pathological changes that could lead to thickening in aortic intima-media layers. TGF ß1 expression was negative in the abdominal aorta that can predispose to the development of atherosclerosis, which could develop overtime. This finding may be interpreted as an appropriate basis for the development of atherosclerosis. In the thoracic aorta TGF ß1 may coordinate cellular events such as tissue repair.Öğe Well-differentiated mucinous cystadenocarcinoma of the renal pelvis [Renal pelvisin İyi diferansiye müsinöz kistadenokarsinomu](TIP ARASTIRMALARI DERNEGI, 2014) Sonmez F.C.; Esen H.H.; Tavli L.; Kilinç M.Adenocarcinoma arising from renal pelvis is uncommon. A mucinous cystadenoma of the renal pelvis with malignant transformation is a rare entity. We report a case of well-differentiated mucinous cystadenocarcinoma of the renal pelvis with malignant transformation of cystadenoma with mucus-filled kidney (muconephrosis) due to mucin produced by the tumor.
