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    Investigation of histopathologic changes in the ureter walls in experimental congenital obstructive uropathy
    (W B SAUNDERS CO-ELSEVIER INC, 2008) Guerbuezer, Nilifer; Yurtcu, Mueslim; Findik, Siddika; Avunduk, Mustafa Cihat; Gunel, Engin
    Background/Purpose: The aim of this study is to determine the histopathologic changes in the ureter wall in experimental urinary bladder hypoplasia and agenesis. Methods: Timed pregnant rats were randomly divided and received intraperitoneal Adriamycin (ADR) at 2 mg/kg on gestational days (GD) 6 to 9 (ADR group) and saline at 2 mL/kg on GD 6 to 9 (SF group). The control (C) group did not receive any medication in their pregnancy. Fetuses were harvested near term on GD 21 and dissected under a dissecting microscope and examined for urinary system abnormalities. Results: Diameter of ureter lumen was significantly increased, but wall thickness, tunica muscularis, and epithelial thickness of the ureter were decreased in the ADR group as compared with the C and SF groups. Conclusions: Diameter of the ureter lumen was increased, but wall thickness, tunica muscularis, and uroepithelium of the ureter were decreased in the ADR group in the intrauterine period. The diameter of the ureter lumen and wall thickness Of ureter (tunica muscularis of ureter and uroepithelium) were increased following obstructive uropathy after the birth. (C) 2008 Elsevier Inc. All rights reserved.
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    Investigation of histopathologic changes in the ureter walls in vesicoureteral reflux
    (W B SAUNDERS CO-ELSEVIER INC, 2009) Yurtcu, Mueslim; Gurbuzer, Nilifer; Findik, Siddika; Avunduk, Mustafa Cihat; Gunel, Engin
    Purpose: This study aimed to determine the histopathologic changes in ureteral walls (UWs) in children with vesicoureteral reflux (VUR). Methods: Twenty ureteral specimens taken from children were divided into 2 groups, refluxing (R) and control (C) groups, each containing 10 specimens. Wall thickness of the ureter, tunica muscularis of the ureter, mucosal thickness of the ureter (uroepithelium), collagen thickness of the ureter, mucosal change, and inflammation were evaluated in resected distal UWs in children with VUR. Results: The mean wall thickness of the ureter, mean tunica muscularis of the ureter, and mean uroepithelium values of the UWs in the R group were not significantly lower compared to those in the C group. Collagen thickness values in the R group were significantly lower than those in the C group. Conclusions: Our data suggest that wall thickness (tunica muscularis and uroepithelium) was not significantly decreased, but collagen thickness of the ureter was decreased in the UWs of children with VUR. (C) 2009 Elsevier Inc. All rights reserved.