Investigation of histopathologic changes in the ureter walls in experimental congenital obstructive uropathy
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B SAUNDERS CO-ELSEVIER INC
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background/Purpose: The aim of this study is to determine the histopathologic changes in the ureter wall in experimental urinary bladder hypoplasia and agenesis. Methods: Timed pregnant rats were randomly divided and received intraperitoneal Adriamycin (ADR) at 2 mg/kg on gestational days (GD) 6 to 9 (ADR group) and saline at 2 mL/kg on GD 6 to 9 (SF group). The control (C) group did not receive any medication in their pregnancy. Fetuses were harvested near term on GD 21 and dissected under a dissecting microscope and examined for urinary system abnormalities. Results: Diameter of ureter lumen was significantly increased, but wall thickness, tunica muscularis, and epithelial thickness of the ureter were decreased in the ADR group as compared with the C and SF groups. Conclusions: Diameter of the ureter lumen was increased, but wall thickness, tunica muscularis, and uroepithelium of the ureter were decreased in the ADR group in the intrauterine period. The diameter of the ureter lumen and wall thickness Of ureter (tunica muscularis of ureter and uroepithelium) were increased following obstructive uropathy after the birth. (C) 2008 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
adriamycin, congenital obstructive uropathy, ureteral wall, ureteral epithelium
Kaynak
JOURNAL OF PEDIATRIC SURGERY
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
43
Sayı
8
