Investigation of histopathologic changes in the ureter walls in experimental congenital obstructive uropathy

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dc.contributor.authorGuerbuezer, Nilifer
dc.contributor.authorYurtcu, Mueslim
dc.contributor.authorFindik, Siddika
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorGunel, Engin
dc.date.accessioned2020-03-26T17:27:06Z
dc.date.available2020-03-26T17:27:06Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground/Purpose: The aim of this study is to determine the histopathologic changes in the ureter wall in experimental urinary bladder hypoplasia and agenesis. Methods: Timed pregnant rats were randomly divided and received intraperitoneal Adriamycin (ADR) at 2 mg/kg on gestational days (GD) 6 to 9 (ADR group) and saline at 2 mL/kg on GD 6 to 9 (SF group). The control (C) group did not receive any medication in their pregnancy. Fetuses were harvested near term on GD 21 and dissected under a dissecting microscope and examined for urinary system abnormalities. Results: Diameter of ureter lumen was significantly increased, but wall thickness, tunica muscularis, and epithelial thickness of the ureter were decreased in the ADR group as compared with the C and SF groups. Conclusions: Diameter of the ureter lumen was increased, but wall thickness, tunica muscularis, and uroepithelium of the ureter were decreased in the ADR group in the intrauterine period. The diameter of the ureter lumen and wall thickness Of ureter (tunica muscularis of ureter and uroepithelium) were increased following obstructive uropathy after the birth. (C) 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpedsurg.2007.11.025en_US
dc.identifier.endpage1527en_US
dc.identifier.issn0022-3468en_US
dc.identifier.issue8en_US
dc.identifier.pmid18675646en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1524en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpedsurg.2007.11.025
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22471
dc.identifier.volume43en_US
dc.identifier.wosWOS:000258592500018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectadriamycinen_US
dc.subjectcongenital obstructive uropathyen_US
dc.subjectureteral wallen_US
dc.subjectureteral epitheliumen_US
dc.titleInvestigation of histopathologic changes in the ureter walls in experimental congenital obstructive uropathyen_US
dc.typeArticleen_US

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