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    Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa
    (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2011) Chicca, Andrea; Tebano, Marianna; Adinolfi, Barbara; Ertugrul, Kuddisi; Flamini, Guido; Nieri, Paola
    The phytochemical investigation of the aerial parts of Centaurea deflexa led to the identification of 21 compounds, among which three phenolic acids, one sterol, ten flavonoids, one phenylpropanoid derivative, two lignans and four sesquiterpene lactones. One of the latter compounds was a new, rare active principle (1) having an uncommon 15-nor-guaianolide skeleton. The biological investigation was carried out through a bio-guided assay fractionation of C deflexa extracts and highlighted an anti-proliferative activity of two sesquiterpene lactones, aguerin B and the newly identified 15-nor-guaianolide (1) against human pancreatic and colonic cancer cells. Of the two compounds, only aguerin B showed to induce apoptotic cell death, confirming the role as pro-apoptotic moiety of the alpha-methylene-gamma-lactone ring present in aguerin B but not in 1. (C) 2011 Elsevier Masson SAS. All rights reserved.
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    Essential Oil Composition of Two Endemic Centaurea Species From Turkey, Centaurea Mucronifera and Centaurea Chrysantha, Collected in the Same Habitat
    (Pergamon-Elsevier Science Ltd, 2003) Dural, Hüseyin; Bağcı, Yavuz; Ertuğrul, Kuddusi; Demirelma, Hakkı; Flamini, Guido; Cioni, Pier Luigi; Morelli, Ivano
    The essential oils of two endemic Centaurea species from Turkey, C. mucronifera and C. chrysantha, collected in the same habitat, have been studied. The main compounds of the former were germacrene D (29.3%), beta-eudesmol (17.4%) and beta-caryophyllene (7.3%), while in the latter germacrene D (27.4%), caryophyllene oxide (9.5%) and bicyclogermacrene (5.4%) were detected among its major constituents. The two species produced many similar compounds in their essential oils that could be justified by the similar ecological conditions of their habitat, but also many differences were found that could confirm their taxonomic separation. (C) 2003 Elsevier Ltd. All rights reserved.
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    Essential Oils From Lowers of Centaurea Kotschyi Var. Kotschyi and C-Kotschyi Var. Decumbens From Turkey
    (Wiley, 2003) Ertuğrul, Kuddusi; Dural, Hüseyin; Tugay, Osman; Flamini, Guido; Cioni, Pier Luigi; Morelli, Ivana
    The compositions of the essential oils obtained from. fresh capitula of Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, two endemic plants from Turkey, have been studied. Sesquiterpenes were the main components of both essential oils, with germacrene D (44.2%), beta-caryophyllene (12.1%) and bicyclogermacrene (5.5%) in C. kotschyi var. kotschyi and germacrene D (29.4%), beta-caryophyllene (11.2%), beta-cedrene (7.1%) in C. kotschyi var. decumbens as the principal components. The qualitative and quantitative differences between the two essential oils are in agreement with,the morphological observation that led to the differentiation of the two varieties. Copyright (C) 2003 John Wiley Sons, Ltd.
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    Flavonoid Glycosides From Centaurea Pseudoscabiosa Subsp Pseudoscabiosa From Turkey
    (Pergamon-Elsevier Science Ltd, 2002) Flamini, Guido; Pardini, Maria; Morelli, Ivano; Ertuğrul, Kuddisi; Dural, Hüseyin; Bağcı, Yavuz; Kargıoğlu, Mustafa
    Three flavonoid glycosides were isolated and characterized, together with a further 13 substances belonging to various classes of compounds, in particular two phenolic acids, a coumarin, a sugar and nine flavonoids from the flowered aerial parts of Centaurea pseudoscabiosa subsp. pseudoscabiosa Boiss. et Buhse (Asteraceae). Some considerations about their evolutionary meaning are provided.