Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The phytochemical investigation of the aerial parts of Centaurea deflexa led to the identification of 21 compounds, among which three phenolic acids, one sterol, ten flavonoids, one phenylpropanoid derivative, two lignans and four sesquiterpene lactones. One of the latter compounds was a new, rare active principle (1) having an uncommon 15-nor-guaianolide skeleton. The biological investigation was carried out through a bio-guided assay fractionation of C deflexa extracts and highlighted an anti-proliferative activity of two sesquiterpene lactones, aguerin B and the newly identified 15-nor-guaianolide (1) against human pancreatic and colonic cancer cells. Of the two compounds, only aguerin B showed to induce apoptotic cell death, confirming the role as pro-apoptotic moiety of the alpha-methylene-gamma-lactone ring present in aguerin B but not in 1. (C) 2011 Elsevier Masson SAS. All rights reserved.
Açıklama
Anahtar Kelimeler
Centaurea, Asteraceae, Sesquiterpene lactone, Guaianolide, Anti-proliferative, Apoptosis
Kaynak
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
46
Sayı
7
