Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa

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dc.contributor.authorChicca, Andrea
dc.contributor.authorTebano, Marianna
dc.contributor.authorAdinolfi, Barbara
dc.contributor.authorErtugrul, Kuddisi
dc.contributor.authorFlamini, Guido
dc.contributor.authorNieri, Paola
dc.date.accessioned2020-03-26T18:13:47Z
dc.date.available2020-03-26T18:13:47Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe phytochemical investigation of the aerial parts of Centaurea deflexa led to the identification of 21 compounds, among which three phenolic acids, one sterol, ten flavonoids, one phenylpropanoid derivative, two lignans and four sesquiterpene lactones. One of the latter compounds was a new, rare active principle (1) having an uncommon 15-nor-guaianolide skeleton. The biological investigation was carried out through a bio-guided assay fractionation of C deflexa extracts and highlighted an anti-proliferative activity of two sesquiterpene lactones, aguerin B and the newly identified 15-nor-guaianolide (1) against human pancreatic and colonic cancer cells. Of the two compounds, only aguerin B showed to induce apoptotic cell death, confirming the role as pro-apoptotic moiety of the alpha-methylene-gamma-lactone ring present in aguerin B but not in 1. (C) 2011 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejmech.2011.03.011en_US
dc.identifier.endpage3070en_US
dc.identifier.issn0223-5234en_US
dc.identifier.issue7en_US
dc.identifier.pmid21458113en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3066en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejmech.2011.03.011
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26153
dc.identifier.volume46en_US
dc.identifier.wosWOS:000291895200046en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERen_US
dc.relation.ispartofEUROPEAN JOURNAL OF MEDICINAL CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCentaureaen_US
dc.subjectAsteraceaeen_US
dc.subjectSesquiterpene lactoneen_US
dc.subjectGuaianolideen_US
dc.subjectAnti-proliferativeen_US
dc.subjectApoptosisen_US
dc.titleAnti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexaen_US
dc.typeArticleen_US

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