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Öğe Effect of oral immunoglobulin G in experimental necrotizing enterocolitis model [Deneysel nekrotizan enterokolit modelinde agizdan verilen immünglobülin G'nin etkisi](2008) Yurtçu M.; Aydogdu B.; Toy H.; Gürbílek M.; Günel E.Aim: Investigation of the protective effect of oral immunglobulin(Ig) G on rat intestinum in experimental necrotizing enterocolitis model. Materials and Methods: 40 newborn rats were devided into 4 groups each containing 10 rats. While control (C) group was fed by breast, the rats in necrotizing enterocolitis (N), sham (S), and treatment (T) groups were settled into incubators at 36°C and 60 % humidity and fed, but not by breast. The rats in group C were breast fed. The rats in N group were fed with Formula as soon as they were born. The rats in T group were fed with Formula and 1200 mg/kg/day oral Ig A with 4-hour intervals. The rats in S group were fed with Formula and 0.1 ml/kg/day distilled water which is solvent of Ig. The rats in all groups were weighed and sacrified on fourth day. 2 cm intestinal segment from proximal of ileocaecal valve was used for histopathologic examination, another 10 cm intestinal segment for biochemical examination. After laparotomy, H&E was used for histopathological examination and apoptosis repressor with card Ab-1 citt for immunohistochemical examination. Biochemical parameters such as TNF-?, and IL-6 were evaluated. Results: The rate of mortality in N, S, and T groups was significantly higher than groups C (P=0.038). Significant weight increase in group C was significantly higher than N, S, and T groups (P=0.000). Histopathologic parameters such as villus injury, transmural necrosis in group C were found to be significantly decreased compared with N, S, and T groups according to scoring system (P=0.000). Apoptosis in group C was found to be significantly decreased compared with N, S, and T groups according to scoring system (P=0.001). IL-6 and TNF-? levels were identified to be significantly decreased in group C compared with N, S, and T groups (P<0.05). There was no significant difference among N, S, and T groups (P>0.05). Conclusion: Pure IgG given orally was not identified to decrease intestinal damage and to prevent NEC in experimental NEC model both biochemically and histopathologically.Öğe Gastric volvulus associated with paraesophageal hernia, Morgagni hernia and liver cyst: A very rare picture of acute abdomen [Gastrik volvulus ile birlikte paraözefageal herni, Morgagni hernisi ve karaci?er kisti: Nadir görülen bir akut batin tablosu](Gulhane Medical School, University of Health Sciences, 2011) Gündüz M.; Yurtçu M.; Günel E.Gastric volvulus may develop primarily as a result of looseness or lack of gastric ligaments or secondarily to paraesophageal or diaphragmatic hernias. Gastric volvulus associated with paraesophageal hernia, Morgagni hernia, and liver cyst is a very rare cause of acute abdomen, and requires prompt surgical intervention. In this article the association of gastric volvulus, paraesophageal hernia, Morgagni hernia and liver cyst is being discussed under the light of current literature data. © Gülhane Askeri Tip Akademisi 2011.Öğe A rare presentation of true hermaphroditism: An abnormal inquinoscrotal mass(2007) Yurtçu M.; Aydo?du B.; Avunduk M.C.; Günel E.This study examined the differential diagnosis of inguinoscrotal masses and true hermaphroditism as well as incarcerated inguinal hernia in the differential diagnosis of abnormal inguinoscrotal masses. Inguinoscrotal masses are a rare presentation of true hermaphroditism. A child with an inguinoscrotal mass of the right groin and penoscrotal hypospadias was diagnosed. Our case suggested that abnormal inguinoscrotal masses occur in true hermaphroditism as well as incarcerated inguinal hernia. These congenital anomalies should be considered in the differential diagnosis of inguinoscrotal masses of the groin. © 2007 Neuroendocrinology Letters.Öğe Uterovaginal agenesis associated with rectovestibuler fistula: Report of two cases [Uterovajinal agenezili rektovestibüler fistül: İki olgu sunumu](2004) Günel E.; Yurtçu M.A very unusual anorectal defect in two patients, consisting of a rectovestibular fistula and uterovaginal agenesis is presented. The defect can be misdiagnosed as imperforate anus with rectovestibular fistula or imperforate anus without fistula and with normal urethral and vaginal openings. A colostomy was opened at the neonatal period in the patients, and definitive repair of the anorectal anomaly was performed when the patients were 6-month-old. With the posterior sagittal approach, the distal rectum was used to create the neovagina in the patients. The proximal rectum was mobilized and placed within the limits of the sphincter mechanism as described by Pena et al. All patients had normal ovaries, but fallopian tubes gradually became cordlike structures as they approached the midline, and the uterus and vagina were completely absent. One patient, who is 4 years old, is continent of urine and has voluntary bowel movements. The other patient is under 3 years of age and is therefore not old enough to determine a clinical result. We don't have evidence that the neovagina functions as a vagina in the patients to allow sexuall activity. The posterior sagittal approach represents another alternative to treat these defects without the need for laparotomy. It is mandatory to perform a meticulous inspection of the perineum in female patients with anorectal malformations to detect unusual defects.
