Yazar "Genç, Mine" seçeneğine göre listele
Listeleniyor 1 - 7 / 7
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Accelerated Hyperfractionated Radiotherapy in Supratentorial Malignant Astrocytomas(Elsevier Sci Ireland Ltd, 2000) Genç, Mine; Zorlu, Abdullah Faruk; Atahan, İbtisam LalePurpose: To determine the safety and effectiveness of accelerated hyperfractionated radiotherapy in the treatment of supratentorial malignant astrocytomas. Materials and methods: Between June 1995-July 1997, 75 patients were enrolled to a prospective phase II study. A total dose of 60 Gy was delivered in 2 Gy b.i.d. fractions with an interval of 6-8 h, 5 days per week, in an overall time of 3 weeks. The treatment protocol was planned to give 40 Gy to a treatment volume covering the contrast-enhancing lesion and oedema (+ 3-cm margin) and additional 20 Gy to the volume encompassing the contrast-enhancing lesion alone with a I-cm margin based on preoperative magnetic resonance imaging and/or CT findings. The patients had a median age of 46 years and a median Karnofsky performance status score of 80, Histology consisted of anaplastic astrocytoma (AA) in 16 (21%) and glioblastoma multiforme (GBM) in 59 (79%) patients. Results: Median survival was 11 months for all patients; 10 months for GEM patients and 40 months for AA patients. Survival rates at 1 and 3 years were 41%, 11% for all patients; 62, 37% for AA patients and 35, 6% for GEM patients, respectively. Multivariate analysis revealed significant impact of age, histology and neurological functional class on survival. The incidence of grade 3 or worse late neurological toxicity was 5.3%. Conclusions: Although accelerated hyperfractionated radiotherapy showed no significant advantage on survival, it shortened the treatment period from 6 to 3 weeks. Radiotherapy was well tolerated and the incidence of late toxicity is acceptable.Öğe Classical Kaposi's Sarcoma: efficacy of single high dose radiotherapy(PERGAMON-ELSEVIER SCIENCE LTD, 2005) Yıldız, Ferah; Genç, Mine; Cengiz, Mustafa; Özyar, Enis; Akbulut, S.; Hurmuz, P.; Atahan, I.[Abstract not Available]Öğe Radiotherapy in the management of Kaposi's sarcoma: Comparison of 8 Gy versus 6 Gy(NATL MED ASSOC, 2006) Yıldız, Ferah; Genç, Mine; Akyürek, Serap; Cengiz, Mustafa; Özyar, Enis; Selek, Uğur; Atahan, I. LaleObjective: To evaluate prospectively the efficacy of a single fraction of high-dose radiotherapy in patients with Kaposi's sarcoma. Patients: Between 1994 and 2004, 47 patients with Kaposi's sarcoma were treated at Hacettepe University, Department of Radiation Oncology. Thirteen (28%) patients received chemotherapy before radiotherapy and were referred due to recurrent or progressive disease or intolerance to chemotherapy. All lesions were treated locally with a 2-3-cm safety margin with 4-6-MeV electron beams. Radiotherapy consisted of a single fraction of 8 Gy in the first four years and 6 Gy thereafter. Results: The male:female ratio was 4:1. The median age was 61 years (range 18-87). Eight out of 47 patients (17%) had an underlying immunocompromised state, and one had a previous diagnosis of Hodgkin's disease. Of 203 fields treated, 51 and 152 fields were treated with 8 Gy and 6 Gy, respectively. Overall response rates (RR) at 12 months for 8- and 6 Gy were 93% and 86%, which were not statistically different. However, the difference between complete RRs at 12 months (93% and 60% for 8 Gy and 6 Gy respectively) was significant (p < 0.0001). Progression-free survival and reirradiation rates were not significantly different. Side effects were tolerable in all but three patients with grade 2-3 fibrosis and edema. Conclusion: Radiotherapy is an effective mode of treatment for Koposi's sarcoma, and a single dose of 8 Gy is more effective in terms of complete RR compared to 6 Gy, though overall response and progression-free survival rates were similar.Öğe Radyoterapi sonrası beyin hasarı ve tedavi yaklaşımları(2006) Genç, Mine; Ergun, Ufuk; Selek, UğurRadyasyona bağlı nörotoksisite nadir ama ciddi bir komplikasyondur. Esas hedef hücreler endotel ve glial hücreler olmakla birlikte günümüzde radyasyona bağlı nörotoksisitenin santral sinir sistemi içindeki parankimal ve vasküler endotelyal hücreler arasındaki kompleks dinamik etkileşimlerden kaynaklandığı düşünülmektedir. Görüntüleme tekniklerindeki gelişmelere rağmen radyasyon nekrozunun tanısı hala zor olup, kesin tanı histopatolojik incelemeyi gerektirir. Hastaların bir kısmı radyasyon nekrozunun cerrahi rezeksiyonundan yararlanır. Kortikosteroidler hem profilaksi hem de tedavide kullanılır. Radyasyona bağlı nörotoksisitenin önlenmesi ve tedavisinde etkili olabilecek büyüme faktörleri, kök hücreler gibi birçok ajan üzerinde araştırmalar devam etmektedir.Öğe Radyoterapiye Bağlı Olarak Gelişen İskemik İnme Olgusu(Turkish Society of Cerebrovascular Diseases, 2009) Genç, Emine; Eruyar, Esra; Genç, B. Oğuz; Genç, MineArteriopathy, a late complication of radiotherapy, is recognized as an important cause of cerebrovascular disease in patients treated with radiotherapy, especially for head and neck cancers. For this reason, determining risk factors for cerebrovascular disease and taking preventive measures may help at least slowing the atherosclerotic process in patients who should undergo radiotherapy.Öğe Results of Conventionally Fractionated Radiotherapy in Supratentorial Malignant Glioma Patients(2002) Gürkaynak, Murat; Genç, Mine; Zorlu, Abdullah Faruk; Akyol, Hüsnü Fadıl; Atahan, İbtisam LaleSixty patients with the diagnosis of supratentorial malignant glial tumor, treated between November 1993-June 1997, were retrospectively analyzed. The patients had a median age of 47 years and a median Karnofsky Performance Status score of 90. Histology consisted of anaplastic astrocytoma in 21 (35%) and glioblastoma multiforme in 39 (65%) patients. Median survival was 13 months for all patients, 12 months for GBM patients and 43 months for AA patients. Survival rates at 1 and 3 years were 55%, 28% for all patients; 39%, 12% for GBM patients and 80%, 54% for AA patients, respectively. Univariate analysis revealed significant impact of histology, KPS, duration of symptoms and age on survival. KPS was found to be an independent prognostic factor according to multivariate analysis. These results were compared with literature.Öğe Spinal seeding of pilocytic astrocytoma: Case report and review of the literature(2005) Gürkaynak, Murat; Büyükpamukçu, Münevver; Zorlu, Abdullah Faruk; Akalan, Nejat; Söylemezoğlu, Figen; Genç, MineA case of cerebellar pilocytic astrocytoma who developed cranial and spinal seedings, 6 years after diagnosis, was presented. The patient was still alive with progressive intracranial and stabile spinal lesions 5 years after completion of radiotherapy.
