Accelerated Hyperfractionated Radiotherapy in Supratentorial Malignant Astrocytomas
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Date
2000
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Sci Ireland Ltd
Access Rights
info:eu-repo/semantics/openAccess
Abstract
Purpose: To determine the safety and effectiveness of accelerated hyperfractionated radiotherapy in the treatment of supratentorial malignant astrocytomas. Materials and methods: Between June 1995-July 1997, 75 patients were enrolled to a prospective phase II study. A total dose of 60 Gy was delivered in 2 Gy b.i.d. fractions with an interval of 6-8 h, 5 days per week, in an overall time of 3 weeks. The treatment protocol was planned to give 40 Gy to a treatment volume covering the contrast-enhancing lesion and oedema (+ 3-cm margin) and additional 20 Gy to the volume encompassing the contrast-enhancing lesion alone with a I-cm margin based on preoperative magnetic resonance imaging and/or CT findings. The patients had a median age of 46 years and a median Karnofsky performance status score of 80, Histology consisted of anaplastic astrocytoma (AA) in 16 (21%) and glioblastoma multiforme (GBM) in 59 (79%) patients. Results: Median survival was 11 months for all patients; 10 months for GEM patients and 40 months for AA patients. Survival rates at 1 and 3 years were 41%, 11% for all patients; 62, 37% for AA patients and 35, 6% for GEM patients, respectively. Multivariate analysis revealed significant impact of age, histology and neurological functional class on survival. The incidence of grade 3 or worse late neurological toxicity was 5.3%. Conclusions: Although accelerated hyperfractionated radiotherapy showed no significant advantage on survival, it shortened the treatment period from 6 to 3 weeks. Radiotherapy was well tolerated and the incidence of late toxicity is acceptable.
Description
Keywords
radiotherapy, malignant astrocytoma, glioblastoma multiforme, accelerated hyperfractionated, supratentorial
Journal or Series
Radiotherapy and Oncology
WoS Q Value
Q1
Scopus Q Value
Q1
Volume
56
Issue
2
Citation
Genç, M., Zorlu, A. F., Atahan, İ. L., (2000). Accelerated Hyperfractionated Radiotherapy in Supratentorial Malignant Astrocytomas. Radiotherapy and Oncology, 56(2), 233-238. Doi: 10.1016/S0167-8140(00)00198-5
