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Öğe Analysis of 24-hour heart rate variations in patients with epilepsy receiving antiepileptic drugs(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011) Yildiz, Gulce Unal; Dogan, Ebru Apaydin; Dogan, Umuttan; Tokgoz, Osman Serhat; Ozdemir, Kurtulus; Genc, Bulent Oguz; Ilhan, NurhanObjective: The goal of the study described here was to evaluate interictal heart rate variability (HRV) in young patients with epilepsy, a patient population in whom sudden unexpected death in epilepsy (SUDEP) is known to be more common. Methods: Twenty-four-hour ambulatory ECG Holter recordings of 37 patients (15-40 years old) and 32 healthy controls were compared. Results: All of the time domain indices (SDNN, SDANN, RMSSD, and HRV triangular index) were significantly suppressed (P < 0.001), and there was a marked reduction in parasympathetic tone (reduced HFnu, P < 0.001) and an increase in sympathetic tone (increased LFnu and LF/HF ratio, P < 0.001) in the patient group. Stepwise linear regression analysis revealed that polytherapy and epilepsy duration > 10 years were independent variables associated with a reduction in SDNN. Conclusion: Our data suggest that the major determinants of suppressed SDNN are polytherapy and epilepsy duration > 10 years. Analysis of spectral measures of frequency domain indices suggests that an increased sympathetic tone in association with a decreased parasympathetic tone may constitute the mechanism underlying SUDEP in young people with epilepsy. (C)2010 Elsevier Inc. All rights reserved.Öğe Auditory P300 event-related potential in tobacco smokers(ELSEVIER SCI LTD, 2009) Guney, Figen; Genc, Bulent Oguz; Kutlu, Ruhusen; Ilhan, Bilge CetinThe aim of this study was to elucidate the chronic effects of tobacco smoking on the P300, a neurophysiological index of cognitive function. Prospective study participants were recruited from a family medicine polyclinic. We selected 32 right-handed smokers who had smoked more than 15 cigarettes per day, by inhalation, for more than 2 years. The control population consisted of 32 right-handed, age-matched healthy individuals who had never smoked. Event-related potentials (ERPs) were recorded with the auditory "oddball" two-tone discrimination task. The data from the central (Cz) and frontal (Fz) electrodes were analyzed. The P300 and NI amplitudes at Fz were lower in the study population compared to the control group. The early component of ERP, the measure of mental speed (N1) latency at Fz was prolonged in the study group compared to the controls, possibly because early cognitive processes such as sensory input or initial encoding of sensory information were delayed in this group. For those who smoke, a decreased NI amplitude might indicate delayed information processing and possibly short-term memory disturbance. Thus, chronic tobacco smoking may produce prefrontal cognitive dysfunction. (C) 2009 Elsevier Ltd. All rights reserved.Öğe Dural Carotico-Cavernous Fistula: Pre and Postembolization Appearances of Bone-Subtracted CT Angiography(TURKISH NEUROSURGICAL SOC, 2013) Koc, Osman; Genc, Emine; Ozturk, Banu; Genc, Bulent Oguz; Keskin, Fatih; Ozbek, OrhanDigital subtraction angiography (DSA) is the best method of evaluating carotid cavernous fistulas (CCF). DSA, however, has the disadvantage of being an invasive procedure. Computerized tomography (CT) angiography which is noninvasive, have been shown to provide more information about the size and location of fistulas. As a new method, Bone-Subtraction CT Angiography (BSCTA), than conventional CT angiography, is a method that improves the detection and interpretation of vascular lesions near to the cavernous segment of carotid artery. In this case report, we report a case of a dural carotico-cavernous fistula (CCF), appearances of pre and postembolization BSCTA images, confirmed by on DSA. As far as we know, CCF demonstrated by BSCTA has not been reported yet.Öğe Dural Carotico-Cavernous Fistula: Pre and Postembolization Appearances of Bone-Subtracted CT Angiography(2013) Koc, Osman; Genc, Emine; Ozturk, Banu; Genc, Bulent Oguz; Keskın, Fatıh; Ozbek, OrhanDij ital subtraksiyon anj iyografi (DSA) karotiko-kavernöz fistülü (KKF) değerlendirmede en iyi metodtur. Ancak DSA invaziv bir yöntemdir. Noninvaziv bir yöntem olan Bilgisayarlı tomografi (BT) anj iyografi fistül lokalizasyonu ve büyüklüğünü gösterebilir. Yeni bir yöntem olan Kemik baskılı BT anj iyografi (KBBTA) özellikle karotid arterin kavernöz segment lezyonlarının saptanmasında ve yorumlanmasında konvansiyonel BT anj iyografiye göre daha değerli bilgiler vermektedir. Bu olgu sunumunda, tanısı DSA ile doğrulanmış KKF olgusunun pre ve postembolizasyon görüntülerini sunduk. Bizim bilgilerimize göre KBBTA ile tanısı konulan KKF olgusu bildirilmemiştir.Öğe Effect of Musical Training on Auditory Event Related Potentials N200 (Mismatch Negativity) and P300(ORTADOGU AD PRES & PUBL CO, 2009) Genc, Emine; Yagisan, Nihan; Dogan, Ebru Apaydin; Genc, Bulent OguzObjective: Studies with endogenous event related potentials, demonstrated that musical training influenced auditory brain functions. The aim of the present study was to investigate whether auditory event related potentials (ERPs)-mismatch negativity (MMN) and P300-differ between musically trained and musically lay subjects. Material and Methods: MMN and P300 were recorded in 19 musically trained (mean age 20.2 +/- 2.38 years) and in 17 musically lay subjects (20.76 +/- 1.75 years) using an "oddball paradigm". 20% of stimuli were rare (target) tones of 2000 Hz, whereas the remainder was frequent (non-target) tones of 1000 Hz. Subjects were instructed to press a button when they encountered the rare stimuli. Latencies and amplitudes of auditory MMN and P300 responses obtained from musically trained subjects were compared to those obtained from musically lay subjects. Results: In musically trained subjects, MMN latencies were significantly decreased while MMN amplitudes did not differ between the 2 groups. P300 latencies and amplitudes did not differ between musically trained and musically lay subjects. Conclusion: Decreased latencies of MMN in musically trained subjects suggest that musical training might influence pre-attentive auditory processing and auditory sensory memory mechanisms can be modulated by musical experience. It is possible that electrophysiological responses obtained from musicians reflect structural adaptations in response to long term music training.Öğe Long-Term Effects of Valproic Acid on Reproductive Endocrine Functions in Turkish Women with Epilepsy(KARGER, 2009) Gorkemli, Huseyin; Genc, Bulent Oguz; Dogan, Ebru Apaydin; Genc, Emine; Ozdemir, SunaThe long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied. Serum reproductive hormone concentrations, clinical findings and ovarian morphology were analyzed in 71 WWE who had been receiving antiepileptic drugs (AED) for a minimum of 2 years. Of the 71 WWE, polycystic ovarian syndrome (PCOS) (p = 0.011) and menstrual irregularities (p = 0.009) were found to be more prevalent in women receiving VPA treatment when compared to women on non-VPA treatment. There was no statistically significant dose or duration-related rise of risk for patients who developed PCOS and menstrual irregularities and those who were not on long-term VPA therapy. The lack of a duration-related reproductive dysfunction in this patient population may support the hypothesis of early occurring VPA-associated metabolic and endocrine changes. Copyright (C) 2009 S. Karger AG, BaselÖğe Ocular Changes Associated with Topiramate(TAYLOR & FRANCIS INC, 2011) Ozturk, Banu Turgut; Genc, Emine; Tokgoz, Mine; Kerimoglu, Hurkan; Genc, Bulent OguzPurpose: To determine the changes in refractive error, and the cornea, anterior chamber, and retina induced by topiramate. Methods: The study included 76 eyes of 38 patients that began to use topiramate due to migraine. Following ophthalmological examination, all of the patients underwent central corneal thickness (CCT), anterior chamber volume (ACV), anterior chamber depth (ACD), and anterior chamber angle (ACA) measurement using a Scheimpflug camera, as well as macular thickness, retinal and retinal nerve fiber layer thickness (RNFLT) measurements using optical coherence tomography (OCT). These procedures were repeated 15, 30, and 90 days after the initiation of topiramate therapy. Results: The median refractive error value showed a statistically significant increase from -0.25 diopters (D) to -0.62 D at the 90th day follow-up (P < 0.001). Mean CCT was 570.56 mu m before treatment and increased to 573.69 mu m at the 15th day follow-up, 575.31 mu m at the 30th day follow-up, and 574.56 mu m at the 90th day follow-up; however, these changes were not statistically significant. Mean ACV, ACD, and ACA did not exhibit statistically significant changes. Mean retinal thickness (RT) increased during the treatment from 263.46 mu m to 271.60 mu m, which was not statistically significant. The initial mean RNFLT was 100.56 +/- 15.36 mu m and significantly increased to 110.2 +/- 8.41 mu m and 111.03 +/- 14.59 mu m at the 30th and 90th day follow-ups, respectively (P = 0.01 and P = 0.004, respectively). Conclusions: During the 3-month follow-up of patients using topiramate 50 mg d(-1) significant myopic shift and an increase in RNFLT were observed. Further studies are warranted in order to assess the effects of topiramate when used long term and at higher doses.
