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    Antidepressant-like effects of quercetin in diabetic rats are independent of hypothalamic-pituitary-adrenal axis
    (CAMBRIDGE UNIV PRESS, 2016) Demir, Enver Ahmet; Gergerlioglu, Hasan Serdar; Oz, Mehmet
    Objective Quercetin, one of the most potent flavonol in the family of flavonoids, has been shown to have benefits against diabetes and its complications. In the present study, we investigated effects of quercetin on depression-like behaviours and hypothalamic-pituitary-adrenal (HPA) axis in diabetic rats. Methods Experimental diabetes was induced by using streptozotocin, and either 50 or 100 mg/kg quercetin was intraperitoneally administered for 21 days. Following the last treatment, animals were subjected to the forced swim test, and subsequently, the blood was obtained by cardiac puncture to measure plasma adrenocorticotropic hormone (ACTH) and corticosterone (CORT) levels. Results A significant increase of the total immobile time, accompanied by a decrease in the immobility latency, which suggests a depressive status, was observed in diabetic animals that was reversed by the treatment of 50 mg/kg quercetin. However, the higher dose of quercetin (100 mg/kg) was ineffective in alleviating depression-like behaviours. The plasma concentrations of ACTH, and total- and free-CORT were not affected by both doses of quercetin. Conclusion Therefore, we concluded that the antidepressant-like effects of quercetin in diabetes are independent of the HPA axis.
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    The Effect of Alpha Lipoic Acid on the Hypothalamic-pituitary-adrenal Axis and Cholinergic System in an Experimental Alzheimer's Model
    (WILEY-BLACKWELL, 2016) Oz, Mehmet; Demir, Enver Ahmet; Gergerlioglu, Hasan Serdar
    [Abstract not Available]
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    EFFECTS OF REPEATED SUPRAMAXIMAL EXERCISES ON PLASMA ADIPONECTIN, IL-6 AND TNF-alpha LEVELS
    (SPRINGER TOKYO, 2009) Gergerlioglu, Hasan Serdar; Gokbel, Hakki; Okudan, Nilsel; Gul, Ibrahim; Belviranli, Muaz; Basarali, Mustafa Kemal
    [Abstract not Available]
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    Oxidative Imbalance in Adult Attention Deficit/Hyperactivity Disorder -- 2
    (ELSEVIER SCIENCE INC, 2009) Selek, Salih; Savas, Haluk A.; Gergerlioglu, Hasan Serdar; Bulut, Mahmut; Yilmaz, H. Ramazan
    [Abstract not Available]
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    Quercetin and caffeic acid phenethyl ester (CAPE) attenuate acute exercise-induced oxidative stress
    (MATTIOLI 1885, 2015) Gergerlioglu, Hasan Serdar; Gokbel, Hakki; Okudan, Nilsel; Gergerlioglu, Nursadan; Demir, Enver Ahmet
    Flavonoids are naturally occurring antioxidant molecules that are abundantly existing in the human diet. We investigated effects of quercetin and caffeic acid phenethyl ester to redox balance in acute treadmill exercise. Malondialdehyde, superoxide dismutase activity, xanthine oxidase activity and total nitrite in blood, skeletal muscle and liver were analyzed in 58 male Sprague-Dawley rats that were exposed to a single bout of exercise. We found that exercise provoked the increment of analyzed parameters except for total nitrite which indicates nitric oxide. Quercetin and caffeic acid phenethyl ester decreased malondialdehyde levels in skeletal muscle and liver. However, they were ineffectual in preventing lipid peroxidation in blood probably due to limited repair and biosynthesis capability of erythrocytes. Since quercetin and CAPE successfully weakened oxidative stress in liver and skeletal muscle, they may be seen as promising in preventing acute exercise-induced oxidative injury.