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ANCA Positive Propylthiouracil Induced, Pyoderma Gangrenosum
(Editrice Kurtis S R L, 2006) Gungor, K.; Gonen, S.; Kisakol, G.; Dikbas, O.; Kaya, A.
Drugs from almost every class of pharmaceutic agent have been reported to cause vasculitis. Vasculitis among patients taking propylthiouracil (PTU) has been reported since 1950s (1) but relation of p-ANCA positive vasculitis in patients with hyper- thyroidism on PTU treatment was first reported by Stankus and Johnson in 1992 (2). In majority of the cases, approximately 80%, pyo- derma gangrenosum (PG) has been associated with systematic diseases such as ulcerative colitis, Crohn's disease, rheumatoid arthritis, Behcet's syndrome, monoclonal gammapathy (especially IgA) and chron- ic myeloid leukemia (3). There were also rare reports about drug induced PG reported to associate with iodide, bromide, isotretinoin, granulocyte colony stimulating factor and granulocyte-macrophage colony stimulating factor (4). PTU induced p-AN?A associated PG has been first reported by Darben et al. (5) in 1999. Hong et al. (6) reported second case in 2004. Here we report another case of PG in a p- ANCA positive patient treated for years with PTU for hyperthyroidism due to Graves' disease.