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Öğe Evaluation of the Prevalence of Temporomandibular Joint Disorder Syndrome in Dental School Students With Psychometric Analysis(2002) Mutlu, Necip; Herken, Hasan; Güray, Enis; Öz, Fatih; Kalaycı, AbdullahAim: Despite the increasing volume of evidence implicating psychological factors in patients with temporomandibular joint (TMJ) disorder syndrome, these aspects of management are frequently neglected. In the diagnosis and treatment of this syndrome, clinical examination must be accompanied by an evaluation of the patients' emotional condition. In our study, the prevalence of TMJ disorders of dental students and the relation between TMJ disorder syndrome and the emotional condition of the patient were evaluated. Methods: The study group consisted of 156 males and 105 females: a total of 261 students. For the psychometric analysis the Minnesota Multiphasic Personality Inventory (MMPI), Symptom Checklist 90-Revised (SCL 90-R), Beck Depression Scale (BDS), Rosenberg Self-Esteem Scale (RSS), and State Trait Anxiety Inventory I and II (STAI-I and II) tests were used. Standard clinical examination protocol was followed. Results: Psychometric measurements revealed significant psychological differences between subjects with the following TMJ disorder syndrome symptoms: hypochondria, hysteria (MMPI), somatization, and anger (SCL 90-R). In both groups, there were no significant differences between the scales of BDS, RSS and STAI-I and II. Clinical examination revealed internal derangement of 18 male and 18 female students and external derangement of 6 male and 1 female students. Conclusion: In terms of the relation to TMJ disorder syndrome, where it affects the patient's emotional condition, psychiatric support can be very useful in the evaluation and treatment of patients with these complaints.Öğe Kronik Şizofreni Hastalarında Klozapin ve Sulpiridin Etkinliğinin Karşılaştırılması(1999) Herken, Hasan; Kaya, Nazmiye; Beşiroğlu, Lütfullah; Derman, Hüdaverdi; Özkan, İshakObject: In this study, a comparison of efficacy and tolerability of clozapine and sulpiride on treatment-resistant-schizophrenia was aimed. Method: Thirty-six in-patients with treatment-resistant schizophrenia, diagnosed according to DSM-IV diagnostic criteria, were given 600-1600 mg/day sulpiride and 300-800 mg/day clozapine, randomly. Patients were evaluated using Brief Psychiatric Rating Scale (BPRS) and UKU- Side Effects Scale on the 15 th, 30th and 60th days of the study. Results: The baseline and the end of the treatment period of Brief Psychiatric Rating Scale (BPRS) points of two groups were compared in the group that was treated with clozapine BPRS- points was significantly lower than the group that was treated with sulpiride. Leucopenia and agranulocytosis did not occur in the clozapine treated group. In the both groups there were no dropouts due to the side effects. Conclusions: It is suggested that the clozapme is more effective than sulpiride on the treatment-resistant- schizophrenia.Öğe Nokturnal bruksizm ile ruhsal belirti arası ilişki(1999) Mutlu, M. Necip; Herken, Hasan; Küçükkolbaşı, Hasan; Turan, Metin; Öztürk, AdnanAmaç: Nokturnal bruksizm dişlerin gıcırdatılması ve sıkılması ile karakterize, toplumda oldukça yaygın görülebilen bir rahatsızlıktır. Etyolojisinde dişsel, psikolojik ve sistemik faktörler etkili olmakla birlikte, emosyonel durum en önemli nedendir. Bu çalışmanın amacı emosyonel durum ile burksizm arasındaki ilişkiyi göstermektir. Materyal ve metod: Çalışma bruksizm yakınması olan (50) ve olmayan (50) toplam 100 öğrenci üzerinde yapılmıştır. Öğrenciler; Hacettepe kişilik envanteri (HKE), ruhsal belirti tarama listesi (SCL-90-R), durumluluk ve süreklik kaygı envanteri (STAİ I-II), Beck depresyon ölçeği (BDÖ), Rosenberg benlik saygısı ölçeği (RSÖ) ve yaşam doyum ölçeği testleri kullanılarak psikometrik açıdan değerlendirilmiştir. Bulgular: Testlerin psikometrik değerlendirmesinde bruksizm yakınması olanlar ile, yakınması olmayanlar arasında Beck depresyon ölçeği, STAI-I, STAI-II, Rosenberg benlik saygısı ölçeğinde anlamlı bir fark bulunmuştur. Ayrıca bruksizm yakınması olanlar ve olmayanların kişilik özellikleri arasında kendini gerçekleştirme, duygusal kararlılık, nörotik eğilim, antisosyal eğilimler ve sosyal uyum değerlendirmeleri arasında anlamlı bir fark bulunmuştur. Sonuç: Nokturnal bruksizm yakınması olan ve kliniğe başvuran hastalarda ruhsal durumun dikkatle ele alınmasının, tedavide önemli bir faktör olduğu görüldü.Öğe Possible Association of Temporomandibular Joint Pain and Dysfunction with a Polymorphism the Serotonin Transporter Gene(MOSBY, INC, 2001) Herken, Hasan; Erdal, Emin; Mutlu, Necip; Barlas, Ömer; Çataloluk, Osman; Öz, Fatih; Güray, EnisThe purpose of this study was to evaluate the relationship between temporomandibular joint pain and dysfunction and serotonin transporter (5-HTT) gene polymorphism. Forty-eight patients with temporomandibular joint pain and 111 healthy control subjects were examined. The results for the patients and control subjects were not significantly different (P > .05). The analysis of genotype distribution (homozygous for STin 2.10 genotypes of the variable-number tandem-repeat polymorphism) showed significant differences between the patients and control subjects (P = .003). ST 2.10 allele was more frequent in the patients with temporomandibular joint pain and dysfunction. In the control group, however, STin 2.12/12 genotype was significantly higher (P = .017). In the patients who were homozygous or heterozygous for variable-number tandem-repeat variants of 5-HTT STin 2.12 copies, the average scores of somatization and anger were significantly higher than those who were homozygous for STin 2.10 variant (P < .05). The patients who were homozygous for STin 2.10 genotype were also homozygous for "L" genotype (P = .019). However, this was not the condition in the control subjects. This study does not provide evidence to support the involvement of 5-HTT gene-linked polymorphic region in temporomandibular joint pain and dysfunction. Our findings indicated that only the presence of the homozygous STin 2.10 genotype of variable-number tandem-repeat is likely to play a substantial role in the genetic predisposition to temporomandibular joint pain and dysfunction and that the STin 2.12/12 genotype may have a protective role against temporomandibular joint pain and dysfunction.