Possible Association of Temporomandibular Joint Pain and Dysfunction with a Polymorphism the Serotonin Transporter Gene
Yükleniyor...
Dosyalar
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
MOSBY, INC
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The purpose of this study was to evaluate the relationship between temporomandibular joint pain and dysfunction and serotonin transporter (5-HTT) gene polymorphism. Forty-eight patients with temporomandibular joint pain and 111 healthy control subjects were examined. The results for the patients and control subjects were not significantly different (P > .05). The analysis of genotype distribution (homozygous for STin 2.10 genotypes of the variable-number tandem-repeat polymorphism) showed significant differences between the patients and control subjects (P = .003). ST 2.10 allele was more frequent in the patients with temporomandibular joint pain and dysfunction. In the control group, however, STin 2.12/12 genotype was significantly higher (P = .017). In the patients who were homozygous or heterozygous for variable-number tandem-repeat variants of 5-HTT STin 2.12 copies, the average scores of somatization and anger were significantly higher than those who were homozygous for STin 2.10 variant (P < .05). The patients who were homozygous for STin 2.10 genotype were also homozygous for "L" genotype (P = .019). However, this was not the condition in the control subjects. This study does not provide evidence to support the involvement of 5-HTT gene-linked polymorphic region in temporomandibular joint pain and dysfunction. Our findings indicated that only the presence of the homozygous STin 2.10 genotype of variable-number tandem-repeat is likely to play a substantial role in the genetic predisposition to temporomandibular joint pain and dysfunction and that the STin 2.12/12 genotype may have a protective role against temporomandibular joint pain and dysfunction.
Açıklama
Anahtar Kelimeler
Kaynak
American Journal of Orthodontics and Dentofacial Orthopedics
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
120
Sayı
3
Künye
Mutlu, N., Öz, F., Güray, E., Herken, H., Erdal, E., Barlas, Ö., Çataloluk, O., (2001). Possible Association of Temporomandibular Joint Pain and Dysfunction with a Polymorphism the Serotonin Transporter Gene. American Journal of Orthodontics and Dentofacial Orthopedics, 120(3), 308-313. Doi:10.1067/mod.2001.115307
