Possible Association of Temporomandibular Joint Pain and Dysfunction with a Polymorphism the Serotonin Transporter Gene

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dc.contributor.authorHerken, Hasan
dc.contributor.authorErdal, Emin
dc.contributor.authorMutlu, Necip
dc.contributor.authorBarlas, Ömer
dc.contributor.authorÇataloluk, Osman
dc.contributor.authorÖz, Fatih
dc.contributor.authorGüray, Enis
dc.date.accessioned2020-03-26T16:37:20Z
dc.date.available2020-03-26T16:37:20Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe purpose of this study was to evaluate the relationship between temporomandibular joint pain and dysfunction and serotonin transporter (5-HTT) gene polymorphism. Forty-eight patients with temporomandibular joint pain and 111 healthy control subjects were examined. The results for the patients and control subjects were not significantly different (P > .05). The analysis of genotype distribution (homozygous for STin 2.10 genotypes of the variable-number tandem-repeat polymorphism) showed significant differences between the patients and control subjects (P = .003). ST 2.10 allele was more frequent in the patients with temporomandibular joint pain and dysfunction. In the control group, however, STin 2.12/12 genotype was significantly higher (P = .017). In the patients who were homozygous or heterozygous for variable-number tandem-repeat variants of 5-HTT STin 2.12 copies, the average scores of somatization and anger were significantly higher than those who were homozygous for STin 2.10 variant (P < .05). The patients who were homozygous for STin 2.10 genotype were also homozygous for "L" genotype (P = .019). However, this was not the condition in the control subjects. This study does not provide evidence to support the involvement of 5-HTT gene-linked polymorphic region in temporomandibular joint pain and dysfunction. Our findings indicated that only the presence of the homozygous STin 2.10 genotype of variable-number tandem-repeat is likely to play a substantial role in the genetic predisposition to temporomandibular joint pain and dysfunction and that the STin 2.12/12 genotype may have a protective role against temporomandibular joint pain and dysfunction.en_US
dc.identifier.citationMutlu, N., Öz, F., Güray, E., Herken, H., Erdal, E., Barlas, Ö., Çataloluk, O., (2001). Possible Association of Temporomandibular Joint Pain and Dysfunction with a Polymorphism the Serotonin Transporter Gene. American Journal of Orthodontics and Dentofacial Orthopedics, 120(3), 308-313. Doi:10.1067/mod.2001.115307
dc.identifier.doi10.1067/mod.2001.115307en_US
dc.identifier.endpage313en_US
dc.identifier.issn0889-5406en_US
dc.identifier.issue3en_US
dc.identifier.pmid11552131en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage308en_US
dc.identifier.urihttps://dx.doi.org/10.1067/mod.2001.115307
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17595
dc.identifier.volume120en_US
dc.identifier.wosWOS:000171164800016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMutlu, Necip
dc.institutionauthorÖz, Fatih
dc.institutionauthorGüray, Enis
dc.language.isoenen_US
dc.publisherMOSBY, INCen_US
dc.relation.ispartofAmerican Journal of Orthodontics and Dentofacial Orthopedicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titlePossible Association of Temporomandibular Joint Pain and Dysfunction with a Polymorphism the Serotonin Transporter Geneen_US
dc.typeArticleen_US

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