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    CXC chemokine ligand 12 and G protein-coupled receptor 30 expressions in canine mammary tumors of mixed origin
    (2018) Alçığır, Mehmet Eray; Anadol, Elvan; Gültiken, Nilgün; Alkan, Kübra Karakaş; Alkan, Hasan; Kanca, Halit
    Canine mammary tumors (CMT) included complex interactions in the etiopathogenesis. It is the most common problemof neoplasia in female dogs. The aim of this study was to reveal the roles of chemokine CXC Ligand 12 (CXCL12) and Gprotein coupled receptor 30 (GPCR30) expressions in the inflammatory process and neoplastic development in caninemammary glands. Therefore, after clinical and pathomorphological evaluation, 18 cases of mixed origin malignant forms(mixed-type carcinoma-n6, complex-type carcinoma-n3, carcinosarcoma-n7, carcinoma and malignantmyoepithelioma-n2)] were examined in the study. Inflammatory cells accompanying neoplastic changes, were determinedto consist of predominantly neutrophils and leukocytes, followed by lymphocytes, plasma cells and macrophages. TheCXCL12 and GPCR30 expressions were scored. immunohistochemically. Most of the expressions for both markers weremoderate in the mammary gland and duct epithelial cells, myoepithelial cells and inflammatory cells. Fibrocytes andfibroblasts gave a mild reaction in general, and no reaction was found in the myxoid, chondroid and osteoid matrix. Therewas considered to be a close relationship between mixed composition CMT and subacute inflammation, and thus it wasconcluded that inflammtory cells may trigger or initiate neoplastic transformation in the cellular environment includingdifferentiated cells of the mammary gland.
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    EXPRESSION OF iNOS, COX-2 AND VEGF IN CANINE MAMMARY TUMOURS AND NON-NEOPLASTIC MAMMARY GLANDS: ASSOCIATION WITH CLINICOPATHOLOGICAL FEATURES AND TUMOUR GRADE
    (AKADEMIAI KIADO RT, 2017) Anadol, Elvan; Sağlam, Atiye Seda Yar; Gültiken, Nilgün; Karakaş, Kübra; Alçığır, Mehmet Eray; Alkan, Hasan; Kanca, Halit
    The aim of the present study was to investigate the relationship between the expression of iNOS, COX-2 and VEGF mRNA levels and malignancy degree in canine malignant mammary tumours. Thirty-five bitches presented with the complaint of mammary masses, aged 6-10 years and representing different breeds, were used. The expressions of iNOS, COX-2 and VEGF mRNA levels were significantly higher in both benign and malignant tumours than in the adjacent nonneoplastic mammary glands (P < 0.05). The iNOS, COX-2 and VEGF mRNA expression levels of grade 2 tumours were higher than those of grade 1 tumours; however, the highest expression levels were detected in grade 3 tumours. Thus, increased iNOS, COX-2 and VEGF gene mRNA levels were found to be related with the histological grade of malignancy in dogs with mammary tumours.