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Öğe Approach to a Patient with Multiple Lung and Brain Carcinomas(GAZI UNIV, FAC MED, 2016) Rencber, Fahri; Kaptan, Hulagu; Karabagli, PinarWe report a case of lung cancer with multiple metastases to the brain. A 55 year-old man suffered onset severe cough and dyspnea. He had no history of any systemic disease. Standard blood work-up was normal. Computed tomographic and bronchoscopic biopsy identified an asymptomatic primary pulmonary large cell neuroendocrine carcinoma in the left upper lobe of the lungs and less differentiated squamous cell carcinoma right upper lobe of the lungs. He also received chemotherapy and radiation therapy to treat the primary lung cancer. Magnetic resonance imaging of the brain revealed multiple intracranial tumors, including 3 cm metastatic mass in left temporal lobe and 3,5 cm metastatic mass in right frontal lobe. There were no metastatic findings in any other organs. First of all, the patient underwent a right frontotemporal approach with total microsurgical resection and after time underwent a left temporal approach with total microsurgical resection. He made good recovery and discharged.Öğe Controlled Trial of Efficacy of Dexketoprofen in Sciatic Nerve Crush Injury in Rats(2014) Kaptan, Hulagu; Kasımcan, Omur; Ayaz, Murat; Bozdogan, Onder; Karabaglı, HakanAmaç: Bu çalışmanın amacı, sıçanlarda siyatik sinir ezilme yaralanmalarında lokal olarak uygulanan deksketoprofen'in etkilerini karşılaştırmaktır. Bunun için sıçan modelinde yaralı siyatik sinirlerin Siyatik Fonksiyon Endeksi ( SFI ), Refleks Bacak geri çekilmesi (WRL), akson sayısı, parametreleri üzerinde 1 gün, 5 gün ve kontrol gruplarında akson çapı ve sinir çapı birlikte değerlendirilerek nöronal hasar incelendi. Yöntem ve Gereç: Wistar albino sıçanlar ( 21 hayvan ) kullanıldı. Sağ siyatik sinir bir Aesculap - Yaşargil anevrizma kullanılarak 10 saniye ezildi ve 10 saniye sonra anevrizma klibi açıldı. Deney hayvanları Grup 1, Grup 2 ve Grup 3 olarak üç gruba ayrıldı. Duyusal fonksiyonun iyileşmesi WRL ile değerlendirildi . Histo-patolojik inceleme yapıldı. Bulgular: Akson sayısı, akson çapı ve sinir çap bazında gruplar arasında anlamlı fark yoktu. Ama yaralanma indüksiyonundan sonra, istatistiksel olarak anlamlı fonksiyonel testler görüldü. Bu etki yalnızca çok dozlu Dex uygulamalarında etkili olarak bulundu. Sonuç: Bu çalışma; 5 gün üst üste deksketoprofen trometamol uygulanmasının, analjezik etkisi ile siyatik sinir hasarı üzerinde olumlu önemli etkilerinin olduğunu ortaya çıkarmıştır.Öğe Controlled Trial of Efficacy of Dexketoprofen in Sciatic Nerve Crush Injury in Rats(JOURNAL NEUROLOGICAL SCIENCES, 2014) Kaptan, Hulagu; Kasimcan, Omur; Ayaz, Murat; Bozdogan, Onder; Karabagli, HakanObject: Local applications of Dexketoprofen trometamol (dex) have been shown to increase in the sciatic nerve functional tests following the nerve injuries. The aim of the current study was to compare the efficacy of dex application for 1 and 5 days following nerve injury rat model. Possible effects of dex were checked by means of the Sciatic Function Index (SFI), Withdrawal of the Reflex Leg (WRL), number of axons, axon diameter, and nerve diameters. Material Methods: The animal crushed model was done through Aesculap -Yasargil aneurysm method on Wistar albino (N=21) right sciatic nerves. In order to achieve desired purpose 3 experimental groups were organized: Group 1: control (injured and no drug); Group2: dexketoprofen 1 days (injured and single dose of drug); Group3: dexketoprofen 5 days (injured and single dose of 5 times drug applications). Injections were done through the tissue expander's injection port with a connecting tube directed at the crush-injured site. Functional recovery of the sciatic nerves was evaluated with the improvement in the SFI values. Additionally, recovery of sensory function was assessed through WRL results and histopathological examination was performed 6 week following the injury. Results: At the end of the experimental periods there was no significant differences were found between the experimental group of animals on the bases of the number of axons, axon diameter, and nerve diameter. Moreover, up 30th day of the experimental period our functional test results have shown that there was no difference between the groups. But following the induction of the injury, the statistical significances were seen on the functional tests. This effect was seen only if the multi-dose application of the dex. Conclusions: This study suggests that; dexketoprofen trometamol of 5 consecutive days, has revealed positive significant changes in the sciatic nerve injury through analgesic effect of it.Öğe Correlation of low back pain caused by lumbar spinal stenosis and depression in women: a clinical study(SPRINGER, 2012) Kaptan, Hulagu; Yalcin, Esra Suer; Kasimcan, OmurLow back pain (LBP) due to spinal stenosis may be one of the most debilitating symptoms to decrease the quality of life. The cause and effect association of LBP and depression is vague. Pain may also be a somatization symptom of depression. This is more frequent in the female population. This clinical study was designed to evaluate the correlation between the level of back pain caused by lumbar spinal stenosis and depression in the female population. The study included 50 consecutive female patients with spinal stenosis. The stenosis diagnosis is made by neurological examination and neuro-imaging. The study group was psychiatrically evaluated and grouped as those with and without depression. Visual analog scale (VAS), Oswestry disability index (ODI) and Hamilton Depression Scale (HDS) were utilized in initial evaluation of the group. Twenty-one patients with lumbar spinal stenosis had depression (DLS Group) and 29 did not (LSS Group). Mean HDS scores were 8.97 and 32.48 for Group LSS and Group DLS, respectively. There was a statistically significant difference between the VAS scores of the groups (the mean VAS scores were 5.6 and 7.6, for groups LSS and DLS, respectively). The mean ODI values for LSS (65.24 +/- A 4.58) and DLS (75.1 +/- A 6.7) groups were also significantly different. In Group DLS, there were positive correlations between ODI and VAS with HDS (p < 0.001). Our findings indicated a relationship between lumbar spinal stenosis associated pain levels and depression. However, the cause and result relationship still needs to be established yet.Öğe Effects of selenium on electrophysiological changes associated with diabetic peripheral neuropathy(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2011) Ayaz, Murat; Kaptan, HulaguOur previous study has demonstrated that sodium selenite prevents oxidative stress, suggesting that selenium can improve diabetic peripheral neuropathy. Results from this study demonstrated that diabetes mellitus resulted in significant increased time to peak, as well as rheobase and chronaxie values. In addition, maximum depolarization, area under compound action potential, kinetics, and conduction velocities of fast and slow nerve fiber groups were decreased. Sodium selenite exhibited positive effects on alterations of diabetes mellitus-induced conduction velocity distribution. This neuroprotective effect was primarily observed in the area under compound action potential and compound action potential kinetic waveforms, as well as rheobase and chronaxie. Results from this study showed that selenium supplementation blocked the diabetes mellitus-induced shift of actively contributing nerve fibers, and restored levels towards age-matched control group values. Chronic selenate supplementation for experimental diabetic peripheral neuropathy exhibited protective effects in measured electrophysiological parameters.Öğe Lumbar Disc Hernia and Erectile Dysfunction(AVES, 2011) Kaptan, Hulagu; Kulaksizoglu, Haluk; Kasimcan, OmurLumbosacral disc disease and sexual dysfunction are two non-lethal health entities that are common and decrease quality of life of patients. With interruption of communication between the brain and the penis, erectile dysfunction should be expected. However, there are very limited data on the interaction of lumbosacral disc disease and sexual functioning. The aim of this review is to highlight the association between lumbosacral disc disease and sexual dysfunction and to overview the diagnosis and treatment options for this subset of patients. (Archives of Neuropsychiatry 2011; 48 Supplement 1:31-4)
