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Öğe Amigdalin ile Zehirlenen Koyunların Kobalt Klorür ve Sodyum Tiyosülfat ile Tedavisi(Selçuk Üniversitesi, 1996) Pirinçci, İbrahim; Tanyıldızı, Sadettin; Ateşşahin, Ahmet; Kara, Haki; Özaydın, SongülThe presant experiment was carried out to compare the effects of cobaltous chloride and sodium thiosulfate used in the treatment of sheep poisoned with amygdalin. In the study, changes occuring levels of eyanide in the rumen liquor and levels of cyanide, thiocyanate, hemoglobin and methemoglobin in the blood, were determined. In the study, sixteen ewes, aged approximately two years old, were used. The animal on which the experiment was made was fasted from 5 p.m. a day ago to the complement of experiment the next day, Thus, eyanide contaminations due to feed and water were prevented. Amygdalin was given through the rumen probe in the doses of 1,5 mg/kg. Samples of rumen and blood were collected at 1,2,4,8,24,72. hours after amygdalin was given. Samples of the rumen were analysed in terms of the levels cyanide. Samples of the blood were analysed in terms of the levels cyanide, thiocyanate, hemoglobin and methemoglobin. lt was observed that co b alt chloride given in the dos es of 5,1 O and 15 mg/ kg at thirty minules decreased the level of eyanide from 0,21 O ug/ml to 0.079, 0.039 and 0.068 ug/ml at first hour, respectively. On the other hand, it was defined that sodium thiosulfate given in doses of 50, 400 and 600 mg/kg at thirty minutes decreased the level kof eyanide from 0.21 O ug/ml to 0.139, 0.165 and 0.179 u gl ml at first hour, respectively. lt was established that cobaltous chloride + sodium thiosulfate given in the dose of 10+600 mg/kg at thirty minules decreased the level of eyanide from 0.21 O u gl ml to 0.103 ug/ml at first hour. Cobaltous chloride u sed in the treatment of the eyanide poisoning was found to be more elfactive than sodium thiosulfate.Öğe Deneysel Olarak Amigdalin ile Zehirlenen Koyunlarda Serum Kalsiyum, Sodyum, Potasyum, Magnezyum ve Bakır Düzeylerinin Belirlenmesi(Selçuk Üniversitesi, 1996) Pirinçci, İbrahim; Tanyıldızı, Saadettin; Karahan, İzzet; Özaydın, Songül; Kara, Haki; Ateşşahin, AhmetThe present experiment was carried out to investigate the changes occuring calcium, sodium, potassium, magnesıum and copper levels ln the blood of the sheep experimantally poisoned with amygdalin. In the study twenty ewes. aged approximately two years old were used. The animal an which the experiment was made was fasted trom 5 p.m. a day ago to the complement of experiment the next day. Thus. eyanide contamlnatıon due to feed and water were prevented Amygdalin was gıven through the rumen probe ın doses of 0.25. 0.5. 1.0. 1.5 mg/kg. Samples of the blood were collected at 1 ,2,4,8,24.48,72. hours alter amygdaline was given. Samples of the blood were analysed in terms of the levels calcium, sodlum, potasstum, magnesium and copper. In conclusion, the levels of sodlum, potassium and calcium were observed to increase experimentally in the eyanide poisoning. On the other hand, the levels of magnesıum and copper were determined to deereasa experimentally in the eyanide poisoning.Öğe Elazığ Bölgesinde Kesilen Hayvanların Dokularındaki Kadmiyum ve Kurşun Düzeylerinin Belirlenmesi(Selçuk Üniversitesi, 1996) Servi, Kadir; Kara, HakiBu çalışma Elazığ bölgesinde kesilen hayvanların dokularındaki kadmiyum ve kurşun düzeylerinin belirlenmesi amacıyla yapılmıştır. Elazığ bölgesinde kesilen 78 hayvandan toplanan toplam 234 et ve organ örneğinde Atomik Absorpsiyon Spektrofotometrik yöntem kullanılarak kadmiyum ve kurşun düzeyleri belirlendi. Sığırların kas, karaciğer ve böbreklerinde sırasıyla kadmiyum düzeylerinin 0.00-0.38, 0.02- 0.64, 0.14-2.92 µg/g. kurşun düzeylerinin ise 0.00- 1.60, 0.00-1.30 ve 0.00-1.40 µg/g olduğu belirlendi. Koyunların kas, karaciğer ve böbreklerinde kadmiyum düzeylerinin sırasıyla 0.00-0, 50, 0.00-0.36, 0.00-1.74 µg/g, kurşun düzeylerinin ise 0.00-1.60, 0.00-1.30 ve 0.00-1.30 µg/ g arasında değiştiği tespit edildi. Sonuç olarak örneklerde belirlenen kadmijum ve kurşun düzeylerinin bu ürünleri tüketenlerde sağlık açısından bir sakınca oluşturmayacak düzeyde olduğu anlaşıldı.Öğe Farmasotik Preparatlardaki Furosemid Düzeylerinin Belirlenmesi(Selçuk Üniversitesi, 1998) Pirinçci, İbrahim; Karahan, İzzet; Servi, Kadir; Kara, HakiFurosemide is an orthochlorosfonamid derivative that is a polenl diuretic. This compound marketed by some chemical lactories is an agent widely used lor therapy ol oedema. This study was made lo investigate whether preparatlons had the descriplion levels ol lurosemide or not. Furosemide preparations were analyzed by specırophotometric method. Absorbances were measured al 630 nm. Means ol lurosemide levels in the tablets and solutlons were determinated 39.96±1.89 and 18.62±O.64 mg respectlvely.Öğe Koyunlarda Si?yanojenik Gli?kozi?tlerle Zehi?rlenmeler Üzeri?ne Deneysel Çalışmalar(Selçuk Üniversitesi, 1997 Ocak) Pirinçci, İbrahim; Tanyıldızı, Sadettin; Özaydın, Songül; Kara, Haki; Ateşşahin, AhmetThe present experiment was made to determinate the changes in the cyanide levels of rumen liquor and the cyanide, thiocyanate, hemoglobin ve methemoglobin levels in blood of the sheep experimentally poisoned with amygdalin. Amygdalin was given in the doses of 0.25, 0.5, 1 and 1.5 mg/kg through rumen probe. An increase was observed in the cyanide levels of rumen and the cyanide and thiocyanate levels of blood after 30, minutes. Blood cya. nide levels arrived maximum at first hour in the all doses of amygdalin (0.25, 0.5, 1 and 1.5 mg/kg). Blood thiocyanate levels reached maximum at first hour in the amount of 0.25 and 0.5 mg/kg and at second hour in the amount of 1 and 1.5 mg/kg after dosing. The cyanide and thiocyanate levels gradually reduced and then decreased the near levels of control groups at 72. hours. The hemoglobin and methemoglobin levels in blood didn't show importantly changes.Öğe Sodyum Nitroprussit Veri?len Farelerde Dokulardaki? Si?yanür ve Ti?yosi?yanat Düzeyleri?ni?n Beli?rlenmesi?(Selçuk Üniversitesi, 1997 Ocak) Pirinçci, İbrahim; Tanyıldızı, Sadettin; Ateşşahin, Ahmet; Kara, Haki; Özaydın, SongülIn this study, cyanide and thiocyanate levels at liver. spleen, kidney and muscle tissue samples obtained from mice which were given different doses sodium nitroprusside (SNP) were investigated. The cyanide and thiocyanate levels in the samples were colorimetrically determined the oxidation of cyanide and thiocyanate by bromine water and coupling of pyridine benzidine reagents. Absorbances were measured at 532 nm. The cyanide and thi ocyanate levels in tissue samples increased after 12 h. and arrived the maximum levels at the different times according to doses. Then the cyanide and thiocyanate levels in samples decreased the same levels with control groups at 192 h.