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    Evaluation of FDG Uptake in Pulmonary Hila with FDG PET/CT and Contrast-Enhanced CT in Patients with Thoracic and Non-Thoracic Tumors
    (Springer, 2010) Kara Gedik, Gonca; Özcan Kara, Pelin; Kara, Taylan; Sarı, Oktay; Kara, Fatih
    Objective Fluorine-18 fluorodeoxyglucose (FDG) uptake is frequently observed in lung hilus. This finding causes difficulties during the interpretation. Our objective was to evaluate the features of FDG uptake in lung hilus associated with benign or malignant etiology in patients with thoracic and non-thoracic tumors. Methods We retrospectively evaluated the files of 1172 patients who had undergone FDG positron emission tomography (PET)/computed tomography (CT) examination between January 2008 and June 2009. Forty-eight patients (21 males, 27 females, age range 12-80 years, mean 60.9 +/- 15.82 years) with either unilateral or bilateral hilar FDG uptake and who had thorax contrast-enhanced computed tomography (CECT) performed within 1 month of the FDG PET/CT scan were enrolled in the study. Characteristics of FDG uptake were classified according to the pathology and CECT or PET/CT follow-up over 12 months. Results The characteristics of 71 hilar regions with FDG uptake could be classified. In 30 of 71 (42.3%) hilar regions, FDG uptake was considered to be physiological because no lymph node was observed on CECT. In 19 of 71 (26.8%), FDG uptake was secondary to benign lymph nodes and in 22 (30.9%) to malignant lymph nodes. Significant differences were observed between benign and malignant lymph nodes for SUVhilus and SUVhilus/SUVliver ratio. Using 4.49 as the cut-off value for SUVhilus, a sensitivity of 85.7% and a specificity of 86.4% were achieved (area under curve, AUC: 0.956). For SUVhilus/SUVliver ratio, sensitivity and specificity to detect malignant lymph nodes were 77.6 and 77.3% (AUC: 0.885), respectively, at a cut-off value of 1.75. Conclusion SUVhilus and SUVhilus/SUVliver ratio were found to be significant parameters for determining malignancy in lung hilus. Combined interpretation with CECT is warranted during the evaluation of lung hilus with FDG PET/CT.
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    FDG-PET/CT Imaging in a Patient With Lymphangiosarcoma
    (Lippincott Williams & Wilkins, 2010) Kara, Pelin Özcan; Kara Gedik, Gonca; Sarı, Oktay; Kara, Taylan; Yılmaz, Farise
    Lymphangiosarcoma is a well-recognized complication of chronic lymphedema. We present a rare case of lymphangiosarcoma in a 34-year-old woman who presented with a mass on her left lymphedematous leg. Her leg had become persistently swollen in the weeks during pregnancy and a clinical diagnosis of lymphedema was made, initially. During the third trimester, she developed an ulcerated mass lesion. MRI and FDG-PET/CT scans were performed after delivery. MRI demonstrated a 6 8 9.5 cm mass in the left thigh. Biopsy of the lesion was consistent with lymphangiosarcoma. FDG-PET/CT demonstrated the primary lesion and its distant metastases.
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    The Role of Dynamic Renal Scintigraphy in Detecting Vesicoureteral Reflux
    (Selçuk Üniversitesi, 2023 Ekim) Sarıkaya, Mehmet; Önner, Hasan; Özcan Sıkı, Fatma; Yılmaz, Farise; Kara Gedik, Gonca; Çiftçi, İlhan
    Aims: This study aims to evaluate the role of standardized dynamic renal scintigraphy (DRS) in recognizing vesicoureteral reflux (VUR) in patients detected with VUR by voiding cystourethrography (VCUG). Methods: The data of all pediatric patients who underwent both VCUG and DRS [technetium-99m diethylenetriaminepentaacetic acid (Tc-99m DTPA) or technetium-99m mercaptoacetyltriglycine dynamic renal scintigraphy (Tc-99m MAG-3)] in our hospital between 2013 and 2022 were retrospectively reviewed. Tc-99m MAG-3 was used in infants and Tc-99m DTPA radiopharmaceutical in children over one year old. According to VCUG findings, VUR grades were grouped as grade I-II-III low-grade VUR and IV-V high-grade VUR. The role of DRS in detecting VUR in both low and high-VUR-grade groups was evaluated. Results: A total of 56 patients (and 69 renal units), 23 girls (%41.1), and 33 boys (%68.9) were included in this study. The median value of the time elapsed between the DRS and VCUG examinations was nine days. According to VCUG, VUR was grade I in five renal units, grade II in 19 renal units, grade III in six renal units, grade IV in six renal units, and grade V in 33 renal units. DRS detected VUR in two of 30 renal units (%6.7) in the low VUR grade group. On the other hand, VUR was observed with DRS in 27 of 39 renal units (%69.2) in the high VUR grade group. Conclusions: Standardized DRS shows very low sensitivity in recognizing low-grade VUR, and its performance in detecting high-grade VUR is comparatively better. Increasing the awareness of clinicians about the detection of VUR with standardized DRS will benefit patients.
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    Undescended Testis in Inguinal Canal Detected Incidentally on Fluorodeoxyglucose PET/CT Imaging
    (ELSEVIER SCIENCE INC, 2012) Özcan Kara, Pelin; Kaya, Buğra; Kara Gedik, Gonca; Sarı, Oktay; Varoğlu, Erhan
    The differential diagnosis at the inguinal region is very important for hypermetabolic foci because of the possibility of metastasis at this level in cancer patients ongoing PET imaging for detection of metastases. It is important to distinguish this activity from other possible malignant and benign conditions such as lymph node activity, testicular cancer, metastatic disease activity, inflammation and urine skin contamination artefact (1). A 66-year-old male patient with operated colon cancer and liver metastasis was referred for PET/CT examination for re-staging because of suspicious metastases. Findings of PET/CT imaging with undescended testis detected incidentally was presented.