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Öğe Comparison of Effects of Somatostatine and Octreotide in the Treatment of Acute Pancreatitis(2001) Şahin, Mustafa; Avşar, Fatih Mehmet; Vatansev, Hüsamettin; Tekin, Şakir; Gürbilek, Mehmet; Karademir, Mehmet; Yılmaz, OsmanAkut pankreatit ciddi bir hastalıktır ve tedavi seçeneklerinin yararları tartışılmaya devam etmektedir. Akut pankreatitte octreotid ve somatostatin 'in etkilerini araştırmaktadır. Çalışmaya 48 adet Spraque-Dawley raflar alındı. Raflar 4 gruba ayrıldı Her grupta ana biliopankreatit duktusbağlanarak akut pankreatit oluşturuldu. Grup I; kontrol grubu, Grup II; 35 mcg/kg/4 st somotostatin kuyruk veninden yapıldı, Grup III; 1.3 mcg/kg/8 st oktreotid subkutan yapıldı, Grup IV; her iki ürün birlikte aynı doz ve aralıklarla uygulandı. Ameliyat öncesi vepost-op 48.saatte serolojik, hematolojik ve gazometrik ölçümler için kan örnekleri alındı. Katlar çalışmanın 48. saatinde sakrifiye edildiler. Pankreas, karaciğer ve akciğerden doku örnekleri alındı.Toplam 15 rat öldü ve gruplararası mortalite oranları arasında anlamlı farklılık bulundu (p0.05). Ameliyat öncesi alınan kanda çalışılan serolojik, hematolojik ve gazometrik parametreler bütün gruplarda benzerdi. Post-op 48 saat sonra, 1. grupta 8, 2. grupta 5, 3. grupta 4 ve 4. grupta 5 parametre, preoperatif sonuçlara kıyasla daha kötü bulundu. Her grupta interstisyel ödem ve iltihabi hücre infiltrasyonu gözlendi., fakat sadece 1. grupta kanama alanları görüldü. Sonuç olarak, akut pankreatitin erken döneminde tedavi amacıyla kullanıldıkları zaman somatostatin ve oktreotid'in etkili olabilecekleri kanaatindeyiz.Öğe The Effects of Different Suture Techniques on Wound Healing in Abdomibnal Wall Closure(2001) Şahin, Mustafa; Karademir, Mehmet; Özer, Şükrü; Avşar, Fatih Mehmet; Çağlayan, Osman; Aksoy, Faruk; Aktan, MuratPurpose: The aim this study was to investigate the effects of different suture techniques on the healing of abdominal wall wound. Materials and Methods: 24 male Wistar albino rats were included in this study. The rats were divided into two groups. A 4 cm midline laparatomy was performed after ketamine HCl anesthesia. In Group I, the incision was sutured with 4/0 polypropylene interruptedly and in Group II, the wound was closed with 4/0 polypropylene continuously. The skin was sutured with an interrupted 4/0 silk suture. Then 2 cc of blood was withdrawn for biochemical and hematological tests by cardiac puncture. All the rats were killed on the 7th postoperative day. Tensile strength were measured and tissue samples were taken for hydroxyproline measurements and histopathological evaluation. Meanwhile intraabdominal adhesions were recorded. Results: Tensile strength was 751±31 g in Group I and 622±28 g in Group II. The difference was significant (p<0.05). Hydroxyproline levels were 3.13±0.15 µg/mg tissue in Group I and 2.81±0.15 µg/mg tissue in Group II. The difference was significant (p<0.05). Intraabdominal adhesions were found in 3 rats in Group I and in 6 rats in Group II. There was a significant difference between the two groups regarding tissue fibroblast numbers (p<0.05). There was no significant difference between serological and hematological tests in the two groups. Conclusion: Closing the abdominal wall wound with the interrupted suture technique gave better results than with the continuous suture technique.Öğe The Effects of Different Suture Techniques on Wound Healing in Abdominal Wall Closure(2001) Şahin, Mustafa; Karademir, Mehmet; Özer, Şükrü; Avşar, Fatih Mehmet; Çağlayan, Osman; Aksoy, Faruk; Aktan, MuratPurpose: The aim this study was to investigate the effects of different suture techniques on the healing of abdominal wall wound. Materials and Methods: 24 male Wistar albino rats were included in this study. The rats were divided into two groups. A 4 cm midline laparatomy was performed after ketamine HCl anesthesia. In Group I, the incision was sutured with 4/0 polypropylene interruptedly and in Group II, the wound was closed with 4/0 polypropylene continuously. The skin was sutured with an interrupted 4/0 silk suture. Then 2 cc of blood was withdrawn for biochemical and hematological tests by cardiac puncture. All the rats were killed on the 7th postoperative day. Tensile strength were measured and tissue samples were taken for hydroxyproline measurements and histopathological evaluation. Meanwhile intraabdominal adhesions were recorded. Results: Tensile strength was 751±31 g in Group I and 622±28 g in Group II. The difference was significant (p<0.05). Hydroxyproline levels were 3.13±0.15 ?g/mg tissue in Group I and 2.81±0.15 ?g/mg tissue in Group II. The difference was significant (p<0.05). Intraabdominal adhesions were found in 3 rats in Group I and in 6 rats in Group II. There was a significant difference between the two groups regarding tissue fibroblast numbers (p<O.05). There was no significant difference between serological and hematological tests in the two groups. Conclusion: Closing the abdominal wall wound with the interrupted suture technique gave better results than with the continuous suture technique.Öğe The impact of oral feeding on the severity of acute pancreatitis(CAHNERS PUBL CO, 1999) Şahin, Mustafa; Özer, Şükrü; Vatansev, Celalettin; Aköz, Mehmet; Vatansev, Hüsamettin; Aksoy, Faruk; Dilsiz, Alaattin; Yılmaz, Osman; Karademir, Mehmet; Aktan, MuratBACKGROUND: In the management of acute pancreatitis, oral feeding is prohibited and either enteral or parenteral feeding is commenced for the patients in an effort to not increase the secretion of the pancreatic enzymes. PURPOSE: This study was undertaken in an attempt to determine the impact of oral feeding on the severity of acute pancreatitis and to compare this impact with that of parenteral feeding. MATERIALS AND METHODS: Twenty-four female Sprague-Dawley rats were divided into two groups. In both groups, acute pancreatitis was induced by ligation of the main biliopancreatic duct. The rats in group I were fed orally and the rats in group II were fed parenterally, The rats were sacrificed at 48 hours, and blood samples were obtained from the heart upon exposure of the abdominal and thoracic cavities, The pancreas and the left lung were removed for histopathological examination, The levels of lactic dehydrogenase (LDH), serum glutamic oxaloacetic transaminase (SGOT), glucose, calcium and blood urea nitrogen, base deficit, partial oxygen pressure, leukocyte count, and hematocrit level among Ranson criteria and the level of amylase were measured, The pancreas and the lung were examined under a light microscope. RESULTS: The levels of LDH, SGOT, and calcium for the rats in group I were significantly higher when compared with the rats in group II (P <0.05), Similarly, the levels of amylase for the rats in group I were found to be higher when compared with the rats in group II, but the difference was not significant. Inflammatory changes observed in the pancreas were less severe whereas inflammatory changes observed in the lung were more severe for the rats in group I when compared with the rats in group II. CONCLUSIONS: The blood levels of the enzymes were adversely affected for the rats fed orally. In contrast, inflammatory changes observed in the pancreas were more severe for the rats fed parenterally, The study suggests that certain hormones released from the duodenum upon stimulation by oral nutrient intake lessens the severity of pancreatitis through protective effects on the pancreas, whereas the elevated levels of the enzymes cause endothelial damage resulting in destruction in distant organs such as the lung.
