Comparison of Effects of Somatostatine and Octreotide in the Treatment of Acute Pancreatitis
Küçük Resim Yok
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Akut pankreatit ciddi bir hastalıktır ve tedavi seçeneklerinin yararları tartışılmaya devam etmektedir. Akut pankreatitte octreotid ve somatostatin 'in etkilerini araştırmaktadır. Çalışmaya 48 adet Spraque-Dawley raflar alındı. Raflar 4 gruba ayrıldı Her grupta ana biliopankreatit duktusbağlanarak akut pankreatit oluşturuldu. Grup I; kontrol grubu, Grup II; 35 mcg/kg/4 st somotostatin kuyruk veninden yapıldı, Grup III; 1.3 mcg/kg/8 st oktreotid subkutan yapıldı, Grup IV; her iki ürün birlikte aynı doz ve aralıklarla uygulandı. Ameliyat öncesi vepost-op 48.saatte serolojik, hematolojik ve gazometrik ölçümler için kan örnekleri alındı. Katlar çalışmanın 48. saatinde sakrifiye edildiler. Pankreas, karaciğer ve akciğerden doku örnekleri alındı.Toplam 15 rat öldü ve gruplararası mortalite oranları arasında anlamlı farklılık bulundu (p0.05). Ameliyat öncesi alınan kanda çalışılan serolojik, hematolojik ve gazometrik parametreler bütün gruplarda benzerdi. Post-op 48 saat sonra, 1. grupta 8, 2. grupta 5, 3. grupta 4 ve 4. grupta 5 parametre, preoperatif sonuçlara kıyasla daha kötü bulundu. Her grupta interstisyel ödem ve iltihabi hücre infiltrasyonu gözlendi., fakat sadece 1. grupta kanama alanları görüldü. Sonuç olarak, akut pankreatitin erken döneminde tedavi amacıyla kullanıldıkları zaman somatostatin ve oktreotid'in etkili olabilecekleri kanaatindeyiz.
Acute pancreatitis is a severe disease and benefits of the treatment options have been under discussion. The aim of this study is to investigate the effects of octreotide and somatostatine in acute pancreatitis. 48 Spraque-Dawley rats were included in this study. The rats were divided into four groups. Acute pancreatitis was performed by main bilio-pancreatic duct ligation in all groups. Group I; control group, Group II; Somatostatin was given 35 mcg/kg/4 hours interval, Group HI; Octreotide was given 1.3 mcg/kg/8 hours interval, Group IV; Somatostatin and octreotid were given together in the same dose as Group II and Group III. Blood samples were taken before the operation and at 48th hour the operation for serological, hematological and gasometric measurements. The rats were sacrificed at 48th hour of the study. Tissue samples were taken from pancreas, liver and lung. A total of 15 rats died from all groups and there was no significant differences in mortality rates between the groups (p>0.05). Serological, hematological and gasometric parameters in the blood samples taken before the operation were similar in all groups. After 48 hour of the operation, 8 parameters in group I, 5 in group II, 4 in group III and 5 in group IV were found worse in the comparison of the preoperative results. Interstitial edema and inflammatory cell infiltration were observed in all groups, but necrosis and hemorrhagic foci were observed only in group I. We concluded that, somatostatin and octreotid may be effective in the treatment of acute pancreatitis when they applied in the early period of the disease.
Acute pancreatitis is a severe disease and benefits of the treatment options have been under discussion. The aim of this study is to investigate the effects of octreotide and somatostatine in acute pancreatitis. 48 Spraque-Dawley rats were included in this study. The rats were divided into four groups. Acute pancreatitis was performed by main bilio-pancreatic duct ligation in all groups. Group I; control group, Group II; Somatostatin was given 35 mcg/kg/4 hours interval, Group HI; Octreotide was given 1.3 mcg/kg/8 hours interval, Group IV; Somatostatin and octreotid were given together in the same dose as Group II and Group III. Blood samples were taken before the operation and at 48th hour the operation for serological, hematological and gasometric measurements. The rats were sacrificed at 48th hour of the study. Tissue samples were taken from pancreas, liver and lung. A total of 15 rats died from all groups and there was no significant differences in mortality rates between the groups (p>0.05). Serological, hematological and gasometric parameters in the blood samples taken before the operation were similar in all groups. After 48 hour of the operation, 8 parameters in group I, 5 in group II, 4 in group III and 5 in group IV were found worse in the comparison of the preoperative results. Interstitial edema and inflammatory cell infiltration were observed in all groups, but necrosis and hemorrhagic foci were observed only in group I. We concluded that, somatostatin and octreotid may be effective in the treatment of acute pancreatitis when they applied in the early period of the disease.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Klinik Laboratuvar Araştırma Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
3
Künye
Şahin, M., Avşar, F. M., Vatansev, H., Tekin, Ş., Gürbilek, M., Karademir, M., Yılmaz, O., (2001). Comparison of Effects of Somatostatine and Octreotide in the Treatment of Acute Pancreatitis. Klinik Laboratuvar Araştırma Dergisi, 5(3), 72-78.
