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Öğe Gastric ulcer penetrating to liver diagnosed by endoscopic biopsy(BAISHIDENG PUBLISHING GROUP INC, 2004) Kayacetin, Ertugrul; Kayacetin, SerraLiver penetration is a rare but serious complication of peptic ulcer disease. Usually the diagnosis is made by operation or autopsy. Clinical and laboratory data were no specific. A 64-year-old man was admitted with upper gastrointestinal bleeding. Hepatic penetration was diagnosed as the cause of bleeding. Endoscopy showed a large gastric ulcer with a pseudotumoral mass protruding from the ulcer bed. Definitive diagnosis was established by endoscopic biopsies of the ulcer base.Öğe Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease(BAISHIDENG PUBLISHING GROUP INC, 2010) Basaranoglu, Metin; Kayacetin, Serra; Yilmaz, Nevin; Kayacetin, Ertugrul; Tarcin, Orhan; Sonsuz, AbdullahA central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood. In the setting of excessive central adiposity, insulin resistance is the major underlying cause of fat accumulation in hepatocytes. Because of the difficulties with human trials, several animal models have been developed for this purpose mainly characterized as follows: genetically disturbed or murine fatty liver, methionine-choline deficient diet fed or murine steatohepatitis, and high-fat or sucrose diet fed models. Although these animal models have provided useful information, none of them accurately reflect genetic, metabolic and biochemical characteristics of the human disease. (C) 2010 Baishideng. All rights reserved.