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    Intratympanic steroid injection and hyperbaric oxygen therapy for the treatment of refractory sudden hearing loss
    (ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL, 2018) Gülüstan, Filiz; Yazıcı, Zahide Mine; Alakhras, Wesam M. E.; Erdur, Ömer; Acıpayam, Harun; Küfeciler, Levent; Kayhan, Fatma Tulin
    Introduction: Controversy surrounds the use of salvage therapies to treat sudden sensorineurat hearing loss (SSNHL), with no consensus on recommendations. White several studies have demonstrated the effectiveness of intratympanic administration of steroids (ITS) and hyperbaric oxygen (HBO) treatment, few have compared the efficacy of ITS and HBO therapy in patients with refractory SSNHL. Objective: We evaluated the efficiency of ITS and HBO therapy in patients with refractory SSNHL. Methods: Patients who did not adequately benefit from systemic treatment were evaluated retrospectively. Refractory patients were defined as those who gained less than 20 dB in hearing after initial treatment. All refractory patients were informed about salvage therapy options: ITS or HBO therapy, the advantages and disadvantages of which were explained briefly. ITS involved 4 mg/mL dexamethasone administered through a 25 gauge needle. Patients underwent HBO therapy in a hyperbaric chamber where they breathed 100% oxygen for 120 min at 2.5 atmospheric pressure. The hearing levels of both groups were evaluated before the salvage therapy and at 3 months after treatment. Improvements in hearing were evaluated according to the Furahashi criteria. We also compared the two therapies in terms of speech discrimination scores (SDSs) and the recovery of all frequencies. Results: The salvage therapies generated similar results. Changes in pure tone averages and SDSs were similar for ITS and HBO therapy (p = 0.364 and p = 0.113). Comparison of SDSs and hearing thresholds at all frequencies showed similar levels of improvement. Conclusion: ITS and HBO therapy produced similar improvements in SSNHL patients, but the sample size was too small to draw definitive conclusions. Further randomized controlled studies are needed to identify the best therapy for patients with refractory sudden hearing loss. (C) 2016 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.
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    PlasmaBlade vs. cold dissection tonsillectomy: A prospective, randomized, double-blind, controlled study in adults
    (VENDOME GROUP LLC, 2017) Yilmazer, Rasim; Yazici, Zahide Mine; Balta, Meliksah; Erdim, Ibrahim; Erdur, Omer; Kayhan, Fatma Tulin
    We conducted a prospective, randomized, double-blind, controlled clinical study to compare the efficacy and safety of the PlasmaBlade device and cold dissection for adult tonsillectomy. Our study group was made up of 20 patients-12 men and 8 women, aged 18 to 50 years (mean: 27.1) who were undergoing a bilateral tonsillectomy. Each patient had one randomly chosen tonsil removed by the PlasmaBlade and the other by cold instrumentation. We compared the duration of surgery, the amount of intraoperative blood loss, the number of sutures required, the status of tonsillar fossa wound healing at 7 and 14 days postoperatively, the amount of postoperative pain, and postoperative complications. We found statistically significant differences in the amount of blood loss and the number of sutures in favor of the PlasmaBlade technique. No significant differences were observed in any of the other outcomes.
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    Role of Apoptosis in the Pathogenesis of Nasal Polyps Based Upon Galectin-3 Expression
    (LIPPINCOTT WILLIAMS & WILKINS, 2017) Cakabay, Taliye; Sayin, Ibrahim; Erdur, Omer; Muhammedoglu, Ali; Tekke, Nihal Seden; Kayhan, Fatma Tulin
    Objective: The authors aimed to investigate the antiapoptotic mechanisms in nasal polyps that occur after glandular hyperplasia. Study Design: Retrospective histopathological analyses of patients with nasal polyps. Methods: The study comprised 54 patients (19 females; 35 males). Group-1 patients with a diagnosis of nasal polyposis; group-2 patients with a diagnosis of antrochoanal polyps; group-3 with a diagnosis of deviation of the nasal septum as a control group. Tissues were taken during their surgery and fixed in paraffin blocks, stained to detect galectin-3, and evaluated under a light microscope. Polymorphonuclear leukocytes on the surface epithelium, glandular epithelium, and connective tissue were divided into groups according to the intensity of galectin-3 staining: "mild,'' "moderate,'' and "strong.'' The percentage of stained tissue was also graded:< 10%, 10% to 50%, 51% to 80%, and >80%. Hence, the extent of expression of galectin-3 and percentage of stained tissue was calculated. Results: Significant differences in the staining intensity of polymorphonuclear leukocytes for galectin-3 were observed between the 3 groups (P<0.01). Staining intensity in control group was significantly lower than that in group I and group II (P = 0.001; P<0.01). However, there was no significant difference between group I and group II (P>0.05). Conclusion: These findings suggest that galectin-3 has a role in the formation of nasal polyps.