Role of Apoptosis in the Pathogenesis of Nasal Polyps Based Upon Galectin-3 Expression
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
LIPPINCOTT WILLIAMS & WILKINS
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The authors aimed to investigate the antiapoptotic mechanisms in nasal polyps that occur after glandular hyperplasia. Study Design: Retrospective histopathological analyses of patients with nasal polyps. Methods: The study comprised 54 patients (19 females; 35 males). Group-1 patients with a diagnosis of nasal polyposis; group-2 patients with a diagnosis of antrochoanal polyps; group-3 with a diagnosis of deviation of the nasal septum as a control group. Tissues were taken during their surgery and fixed in paraffin blocks, stained to detect galectin-3, and evaluated under a light microscope. Polymorphonuclear leukocytes on the surface epithelium, glandular epithelium, and connective tissue were divided into groups according to the intensity of galectin-3 staining: "mild,'' "moderate,'' and "strong.'' The percentage of stained tissue was also graded:< 10%, 10% to 50%, 51% to 80%, and >80%. Hence, the extent of expression of galectin-3 and percentage of stained tissue was calculated. Results: Significant differences in the staining intensity of polymorphonuclear leukocytes for galectin-3 were observed between the 3 groups (P<0.01). Staining intensity in control group was significantly lower than that in group I and group II (P = 0.001; P<0.01). However, there was no significant difference between group I and group II (P>0.05). Conclusion: These findings suggest that galectin-3 has a role in the formation of nasal polyps.
Açıklama
Anahtar Kelimeler
Antrochonal polyp, apoptosis, galectin-3, nasal polyp
Kaynak
JOURNAL OF CRANIOFACIAL SURGERY
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
28
Sayı
1
