Role of Apoptosis in the Pathogenesis of Nasal Polyps Based Upon Galectin-3 Expression

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dc.contributor.authorCakabay, Taliye
dc.contributor.authorSayin, Ibrahim
dc.contributor.authorErdur, Omer
dc.contributor.authorMuhammedoglu, Ali
dc.contributor.authorTekke, Nihal Seden
dc.contributor.authorKayhan, Fatma Tulin
dc.date.accessioned2020-03-26T19:42:32Z
dc.date.available2020-03-26T19:42:32Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The authors aimed to investigate the antiapoptotic mechanisms in nasal polyps that occur after glandular hyperplasia. Study Design: Retrospective histopathological analyses of patients with nasal polyps. Methods: The study comprised 54 patients (19 females; 35 males). Group-1 patients with a diagnosis of nasal polyposis; group-2 patients with a diagnosis of antrochoanal polyps; group-3 with a diagnosis of deviation of the nasal septum as a control group. Tissues were taken during their surgery and fixed in paraffin blocks, stained to detect galectin-3, and evaluated under a light microscope. Polymorphonuclear leukocytes on the surface epithelium, glandular epithelium, and connective tissue were divided into groups according to the intensity of galectin-3 staining: "mild,'' "moderate,'' and "strong.'' The percentage of stained tissue was also graded:< 10%, 10% to 50%, 51% to 80%, and >80%. Hence, the extent of expression of galectin-3 and percentage of stained tissue was calculated. Results: Significant differences in the staining intensity of polymorphonuclear leukocytes for galectin-3 were observed between the 3 groups (P<0.01). Staining intensity in control group was significantly lower than that in group I and group II (P = 0.001; P<0.01). However, there was no significant difference between group I and group II (P>0.05). Conclusion: These findings suggest that galectin-3 has a role in the formation of nasal polyps.en_US
dc.identifier.doi10.1097/SCS.0000000000003174en_US
dc.identifier.endpage284en_US
dc.identifier.issn1049-2275en_US
dc.identifier.issn1536-3732en_US
dc.identifier.issue1en_US
dc.identifier.pmid27922968en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage280en_US
dc.identifier.urihttps://dx.doi.org/10.1097/SCS.0000000000003174
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35449
dc.identifier.volume28en_US
dc.identifier.wosWOS:000392299200067en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofJOURNAL OF CRANIOFACIAL SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntrochonal polypen_US
dc.subjectapoptosisen_US
dc.subjectgalectin-3en_US
dc.subjectnasal polypen_US
dc.titleRole of Apoptosis in the Pathogenesis of Nasal Polyps Based Upon Galectin-3 Expressionen_US
dc.typeArticleen_US

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